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Highlights of NHLBI-supported research presented at American Heart Association's Scientific Sessions
Date:11/17/2009

with heart failure, angiotensin converting enzyme, also known as ACE, inhibitor therapy is common in many pediatric cardiac centers, but has never been tested systematically. ACE inhibitor therapy blocks an enzyme that leads to blood vessel constriction. In this study involving 230 infants, those treated with the ACE inhibitor enalapril were found to have no better growth rates or ventricular function at 14 months of age than infants treated with placebo. Infants in the enalapril and placebo groups registered similar results in a scoring system based on weight for age. With these latest results, researchers must now search for new options to help treat infants with this congenital heart defect. NHLBI Spokesperson: Gail Pearson, M.D., Sc.D. Study Investigator: Daphne T. Hsu, M.D., Division Chief, Pediatric Cardiology, Children's Hospital at Montefiore, can be reached at 917-842-5965 or dhsu@montefiore.org.

No significant cardiovascular differences between liberal and restrictive blood transfusion strategies in surgical hip repair patients. (Embargoed until 8 a.m. EST, Monday, Nov. 16) Patients undergoing hip fracture repair surgery may become anemic after surgery and require blood transfusions. Patients treated by a restrictive transfusion strategy had no significant differences in cardiovascular outcomes compared to similar patients treated with a liberal blood transfusion strategy, according to late-breaking clinical findings from Jeffrey L. Carson, M.D., of the University of Medicine and Dentistry of New Jersey's Robert Wood Johnson Medical School in New Brunswick, N.J. The study involved 2,016 patients, primarily women (75 percent) with a mean age of 81, who had surgery to repair a hip fracture. Some patients received transfusions as soon as their hemoglobin, proteins in the blood that carry iron, levels fell below 10 grams per deciliter (g/dL). Other patients were given blood transfusions o
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Contact: NHLBI Office of Communications
nhlbi_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
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