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Highlights of NHLBI-supported research presented at American Heart Association's Scientific Sessions
Date:11/17/2009

resh supply of oxygen). The alternative method connects the working right ventricle to the pulmonary artery. Surgeons performed the Norwood Procedure using one of the two shunt strategies. Results indicate advantages and disadvantages for both techniques. At 12 months after surgery, 64 percent of infants survived with the MBTS method without the need for a heart transplant, as compared to 74 percent with the other method. After two years, 62 percent of infants treated with the MBTS method survived without the need of a heart transplant as compared to 68 percent with the other method, a difference that is not statistically significant. The results will help develop evidence-based surgical approaches for this group of newborns. NHLBI Spokesperson: Gail Pearson, M.D., Sc.D. Study Investigator: Richard G. Ohye, M.D., University of Michigan Congenital Heart Center, Ann Arbor, Mich. Dr. Ohye can be reached at (734) 936-4978 or ohye@umich.edu.


ACE inhibitor therapy fails to help growth rate or ventricular function in infants with single ventricles. (Embargoed until 4 p.m. EST, Sunday, Nov. 15) At a featured research session on Sunday, investigators in the NHLBI-funded Pediatric Heart Network will report the results of the largest randomized trial conducted to date to assess a treatment for infants with single ventricle physiology, a complex form of congenital heart disease in which either the left or right ventricle (lower chamber) of the heart does not develop properly in utero. The main treatment is surgical: affected infants require one or more major surgical procedures during the first year of life, and experience a high rate of complications and death despite sophisticated treatment strategies. One of the common complications is heart failure, which is when the heart cannot pump blood at its normal capacity, and a slow growth rate. Based on data in adults as well as results of small studies of children
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Contact: NHLBI Office of Communications
nhlbi_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

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