Navigation Links
Highlights from the June issue of GIE: Gastrointestinal Endoscopy
Date:6/23/2014

DOWNERS GROVE, Ill. June 23, 2014 The June issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE), features a study reporting that the annual incidence rate of esophageal cancer among patients with Barrett's esophagus with low-grade dysplasia is 0.54 percent; a study showing that metabolic syndrome and smoking heighten concerns regarding colorectal cancer screening in men with these risk factors; and a new ASGE guideline on endoscopy in patients with lower gastrointestinal bleeding.

"Incidence of esophageal adenocarcinoma in Barrett's esophagus with low-grade dysplasia: a systematic review and meta-analysis"

Barrett's esophagus is a condition in which the lining of the esophagus changes and becomes more like that of the small intestine. It is believed that Barrett's esophagus (BE) occurs because of chronic inflammation resulting from long-standing gastroesophageal reflux disease (GERD). Barrett's esophagus is the most significant risk factor for the development of a certain type of cancer called esophageal adenocarcinoma (EAC). In some patients with BE, further precancerous change in the tissue, called dysplasia, will develop. Those patients that develop dysplasia, especially high-grade dysplasia (BE-HGD), are significantly more likely to develop esophageal cancer. However, most patients with Barrett's esophagus will not develop EAC.

The natural history of how low-grade dysplasia (LGD) in patients with Barrett's esophagus progresses to BE-HGD or EAC is unclear. Researchers performed a systematic review and meta-analysis of cohort studies that reported the incidence of EAC and/or BE-HGD among patients with BE with LGD (BE-LGD) with follow-up of ≥ 2 years. The main outcome measurements were pooled incidence rates of EAC and/or BE-HGD.

Researchers identified 24 studies reporting on 2,694 patients with BE-LGD, with 119 cases of EAC. Pooled annual incidence rates of EAC alone and EAC and/or HGD in patients with BE-LGD were 0.54 percent and 1.73 percent. The results were stable across study setting and location and in high-quality studies. Substantial heterogeneity was observed, which could be explained by stratifying based on LGD/BE ratio as a surrogate for quality of pathology; the pooled annual incidence rates of EAC were 0.76 percent for LGD/BE ratio < 0.15 (surrogate for high-quality pathology) and 0.32 percent for LGD/BE ratio > 0.15 (surrogate for low-quality pathology). The annual rate of mortality not related to esophageal disease in patients with BE-LGD was 4.7 percent.

"Metabolic syndrome and smoking may justify earlier colorectal cancer screening in men"

Despite the overall decline in the incidence of colorectal cancer (CRC) in the United States and the associated mortality resulting from broadly promoted screening programs, there has been an increase in the incidence of CRC in subjects younger than 50 years of age (the recommended screening age for average risk individuals), especially in those aged 40 to 49 years. The cause of such an increase in younger adults remains unclear, but some evidence links it to the increasing prevalence of obesity and metabolic syndrome. Metabolic syndrome (MetS) is characterized by central obesity, high blood pressure, hyperglycemia and dyslipidemia. Because of the adoption of Western dietary habits and lifestyle, many developed Asian countries have witnessed a substantial increase in the prevalence of obesity and MetS over the past few decades.

Gender, smoking and metabolic syndrome are important risk factors of colorectal neoplasm. Whether the presence of these factors warrants earlier screening remains unclear. This study's aim was to compare age- and gender-specific risk of colorectal neoplasms in association with smoking and MetS under endoscopic or stool-based screening. It was a cross-sectional observational study at a screening center in a university hospital in Taiwan. A cohort of 10,884 average-risk individuals 40 years of age or older who received concurrent screening colonoscopy and fecal immunochemical testing (FIT) participated in the study. The main outcome measurements were first, the prevalence of colorectal neoplasms and positive predictive value of FIT relative to age, gender, smoking and MetS. The second outcome measurement was the number of colonoscopies needed with different strategies to detect one advanced neoplasm (defined as lesions larger than 10 mm, and those containing a villous component, severe dysplasia or invasive cancers).

The researchers found that male smokers aged 40 to 49 years had a significantly higher prevalence of advanced neoplasms and positive predictive value of stool tests than nonsmoking counterparts. The prevalence of advanced neoplasms was higher among men aged 40 to 49 years with concurrent MetS and smoking (6.2 percent) or smoking alone (3.8 percent) than that of average risk women aged 50 to 59 years (2.1 percent). The number of colonoscopies needed to detect one advanced neoplasm in men aged 40 to 49 years with concurrent MetS and smoking, smoking, MetS and women aged 50 to 59 years was, respectively, 14.6, 24.8, 39.8 and 47.4 in the colonoscopy scenario and 1.7, 4.6, 5.7 and 8.3 in the FIT scenario. The researchers concluded that MetS and smoking significantly impact both the prevalence of colorectal neoplasms and the diagnostic yields of screening tests in men aged 40 to 49 years. Whether the findings justify earlier screening in this subgroup requires further study.

"The role of endoscopy in the patient with lower GI bleeding"

ASGE has published a new guideline, "The role of endoscopy in the patient with lower GI bleeding." The guideline was prepared by the ASGE Standards of Practice Committee and appears in the journal's June issue and online at http://www.giejournal.org.


'/>"/>

Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

Related medicine news :

1. Study highlights side effects felt by BRCA mutation carriers after cancer risk-reducing procedure
2. Gastroenterology highlights new microbiome research
3. Mothers Day science: Reactions highlights amazing facts about pregnancy -- video
4. Ce-Classes.com Reports Year End Highlights in Continuing Education for Health Care
5. Dr. Michael Schroer of Williamsburg Periodontics Highlights the Connection Between Gum Disease and Pancreatic Cancer this November
6. IBWA Video Highlights Importance of Having Bottled Water as a Choice
7. Study Highlights Challenges for Individuals with Lung Cancer, Allsup Reports
8. Biopharm Insight’s Respiratory Disease Report Highlights Key Drugs Coming Up for Approval or in Late-Stage Development
9. New Video Highlights All-Natural Body Oil from Sublime Beauty®; Now Available
10. Op-Ed Highlights Failure of Texas Tort Reform
11. Best Grow Tent Manufacturer Highlights Maximum Yield's Indoor Hydro Grow Show
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced its strategic partnership with Connance, a healthcare industry leader providing predictive ... proven, proprietary technology combine to provide health systems, hospitals and ambulatory surgical ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: