DOWNERS GROVE, Ill. June 23, 2014 The June issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE), features a study reporting that the annual incidence rate of esophageal cancer among patients with Barrett's esophagus with low-grade dysplasia is 0.54 percent; a study showing that metabolic syndrome and smoking heighten concerns regarding colorectal cancer screening in men with these risk factors; and a new ASGE guideline on endoscopy in patients with lower gastrointestinal bleeding.
"Incidence of esophageal adenocarcinoma in Barrett's esophagus with low-grade dysplasia: a systematic review and meta-analysis"
Barrett's esophagus is a condition in which the lining of the esophagus changes and becomes more like that of the small intestine. It is believed that Barrett's esophagus (BE) occurs because of chronic inflammation resulting from long-standing gastroesophageal reflux disease (GERD). Barrett's esophagus is the most significant risk factor for the development of a certain type of cancer called esophageal adenocarcinoma (EAC). In some patients with BE, further precancerous change in the tissue, called dysplasia, will develop. Those patients that develop dysplasia, especially high-grade dysplasia (BE-HGD), are significantly more likely to develop esophageal cancer. However, most patients with Barrett's esophagus will not develop EAC.
The natural history of how low-grade dysplasia (LGD) in patients with Barrett's esophagus progresses to BE-HGD or EAC is unclear. Researchers performed a systematic review and meta-analysis of cohort studies that reported the incidence of EAC and/or BE-HGD among patients with BE with LGD (BE-LGD) with follow-up of ≥ 2 years. The main outcome measurements were pooled incidence rates of EAC and/or BE-HGD.
Researchers identified 24 studies reporting on 2,694 patients with BE-LGD, with
|Contact: Anne Brownsey|
American Society for Gastrointestinal Endoscopy