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Highest Reported Complete Remission Rate of 35 Percent Achieved in a Phase III Front-Line Multiple Myeloma Trial With Velcade(R) (Bortezomib) for Injection Based Therapy
Date:12/9/2007

- VELCADE based therapy achieved highly significant improvement across all

efficacy endpoints including overall survival -

ATLANTA, Dec. 9 /PRNewswire-FirstCall/ -- Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM) today announced the presentation of results from the 682 patient, randomized, Phase III VISTA(1) trial. These patients with previously untreated multiple myeloma (MM) were ineligible for stem cell transplantation (SCT). The trial compared VELCADE, melphalan and prednisone (VcMP) to melphalan and prednisone (MP) alone, a recognized standard of care in this treatment setting. These data were selected for an oral presentation at the American Society of Hematology (ASH) 49th Annual Meeting in Atlanta, Ga., December 8-11, 2007.

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"The goal of therapy is long-term survival and complete remission is a well-known indicator for survival," said Professor Jesus San-Miguel, M.D., Hematology Department Head, University Hospital of Salamanca and Principal Investigator of the trial. "Data from this rigorously-controlled trial clearly show that VELCADE based therapy should be a standard of care for previously untreated patients, who are not able to receive stem cell transplantation."

Data from the large international clinical trial were presented by Professor San-Miguel. Responses were evaluated by the commonly used M-protein levels measured in serum or urine by a centralized laboratory as well as the most stringent European Group for Blood and Marrow Transplantation (EBMT) criteria:

-- Immunofixation-negative complete remission
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SOURCE Millennium Pharmaceuticals, Inc.
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