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Higher soy intake prior to lung cancer diagnosis linked to longer survival in women
Date:3/25/2013

on lung cancer survival among participants of the Shanghai Women's Health Study, which tracked cancer incidence in 74,941 Shanghai women. Information on usual dietary intake of soy food (soy milk, tofu, fresh and dry soybeans, soy sprouts, and other soy products) was collected in-person at study enrollment and again two years later. Soy food and isoflavone content of various food products was calculated based on the Chinese Food Composition tables. During the course of the study, 444 women were diagnosed with lung cancer. The median time between the first dietary assessment and cancer diagnosis was 5.8 years.

In this analysis, patients were divided into three groups according to soy food intake prior to lung cancer diagnosis. The highest and lowest intake levels were equivalent to approximately 4 oz or more and 2 oz or less tofu per day, respectively. Patients with the highest soy food intake had markedly better overall survival compared with those with the lowest intake ─ 60 percent of patients in the highest intake group and 50 percent in the lowest intake group were alive at twelve months after diagnosis.

The risk of death decreased with increasing soy intake until the intake reached a level equivalent to about 4 oz of tofu per day. Researchers found no additional survival benefit from consuming higher amounts of soy. Similar trends were observed when dietary isoflavone intake was evaluated.

The findings may not necessarily apply beyond this study's population, which has a very low prevalence of cigarette smoking, a known risk factor for the development of lung cancer, and postmenopausal hormone replacement therapy use, a factor that may negatively affect lung cancer prognosis. In addition, the overall soy food intake is higher in Chinese women than in Western women.

"But given the increasing popularity of soy food in the U.S. and elsewhere, and a sizable number of women who don't smoke, the results of this study co
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Contact: Nicole Racadag
nicole.racadag@asco.org
571-483-1354
American Society of Clinical Oncology
Source:Eurekalert

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