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Higher-risk kidneys may help solve organ shortage facing older adults
Date:11/13/2007

pressed that providing elderly patients who have end-state renal disease with scarce kidneys from deceased donors may not represent a worthwhile investment.

Some studies have shown that being older is associated with a higher risk of the transplant failing; other studies have shown that survival of the transplanted organ is similar in all age groups. Moores study reviewed 356 transplants over almost six years with respect to recipient age.

Almost one-third of patients were over age 60 and more half of them (54 percent) received ECD kidneys. There were 26 recipients over age 70 and the oldest recipient was 81 years old.

Patient and organ survival rates were similar regardless of patient age and whether they received an ECD or a standard-criteria donor organ. In addition, the mean waiting time for patients over 60 receiving ECD kidneys was 18 months, compared to 25 months for those receiving standard criteria donor kidneys.

With a mean follow-up of 27 months, patient survival was 91 percent among patients older than 60 years and 95 percent among those younger than 60 years. Survival of the transplanted organ was similar for all age groups: 82 percent in patients over age 60, 83 percent in patients between 40 and 59 years old, and 87 percent in patients 19 to 39 years old.

Survival rates were also similar between patients receiving ECD kidneys and those receiving standard kidneys. Patient survival rates were 93 percent and 89 percent respectively, and kidney survival rates were 82 percent and 81 percent. In the subgroup of recipients over age 70, patient and graft survival rates were both 100.

By directing ECD kidneys to appropriate elderly patients, waiting times can be reduced and survival is similar compared to standard kidneys in the elderly, said Moore. At our center, no specific upper age limit is an absolute barrier to kidney transplantation.

Kidney transplantation is a preferred treatment for en
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Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

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