Navigation Links
Higher radiation dose does not help lung cancer patients live longer
Date:10/3/2011

Miami Beach, Fla., October 3, 2011 A higher dose of radiation (74 Gy) does not improve overall survival for non-small cell lung cancer that has spread to the lymph nodes, compared to the standard radiation dose (60 Gy), according to an interim analysis of a late-breaking randomized study presented at the plenary session, October 3, 2011, at the 53rdAnnual Meeting of the American Society for Radiation Oncology (ASTRO).

"Most radiation oncologists and lung cancer specialists are surprised by this finding. Although the optimal radiation dose for lung cancer patients has not been tested in a randomized phase III trial for over 30 years, most believed that higher doses of radiation cured more patients with lung cancer," Jeffrey Bradley, MD, a radiation oncologist at the Washington University School of Medicine in St. Louis, said.

The goal of the phase III trial was to find out if high doses of radiation improve survival and also if the chemotherapy drug, Cetuximab, increases survival among stage III non-small cell lung cancer patients. Investigators randomized 423 patients to different doses of radiation therapy and concurrent chemotherapy of paclitaxel and carboplatin with or without Cetuximab. Patients received one of four treatment arms: standard-dose (60 Gy) versus high-dose (74 Gy) radiation therapy and to chemotherapy with or without Cetuximab.

Two types of external beam radiation therapy were used during the trial: three-dimensional conformal radiation therapy (3D-CRT), that uses special imaging techniques to precisely tailor the radiation beams so that nearby normal tissue receives less radiation; and intensity modulated radiation therapy, (IMRT), a newer, specialized form of 3D-CRT which further limits the radiation dose to the normal tissues.

Based on the study's early findings, patients who received the higher dose of radiation (74 Gy) did not have better survival rates than those receiving the standard dose (60 Gy); therefore, the two arms of the trial which used high-dose radiation therapy were closed to patient accrual.

"The trial provides class I evidence that the standard dose of radiation therapy for stage III lung cancer should remain at its existing level of (60 Gy) and doses as high as 74 Gy are not better in curing Stage III lung cancer," Dr. Bradley said. "We are not sure why this is the case and our data is still being carefully reviewed."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Minorities Not Treated at Higher-Quality Centers
3. Black Women at Higher Risk of Birth-Related Heart Problem
4. Risk of Childhood Obesity Higher Among Minorities
5. Death After Discharge Rates Higher in Elderly ICU Patients
6. Anti-depressants bring higher risk of developing cataracts: UBC-Vancouver Coastal Health research
7. K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity
8. Do Liberals, Atheists Have Higher IQs?
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. More Money, Increased Participation and Higher Nutritional Standards for School Meals
11. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... The health ... Annual Enrollment Period (AEP) and the Open Enrollment Period (OEP). 2016 was no ... Mainly, people are witnessing higher deductibles, rising premiums, and few choices with their ...
(Date:1/24/2017)... ... January 24, 2017 , ... PeroxyChem Food ... Assurance Control Equipment (PACE), at the International Production and Processing Expo (IPPE) in ... highlight the new technology that is used in poultry processing facilities to provide ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... was recently accepted as a Registered Trademark by the United States Patent and ... a similar name which could confuse consumers into thinking that other products are ...
(Date:1/24/2017)... ... January 24, 2017 , ... Learn to use popular ... or even in relationships. Course offered by Dr. Carol Francis at PVNET on ... limited seating and the many hands-on experiences. , Dr. Carol Francis shows ...
(Date:1/24/2017)... ... January 24, 2017 , ... Seceon , the ... in real-time, today announced a strategic partnership with Paramount , the Middle ... and protect their critical information assets and infrastructure, in a comprehensive and cost ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , January 24, 2017 ... dem Molecular Surgical Laboratory des Massachusetts General Hospital (MGH) ... Dabei geht es um die Identifizierung und Validierung neuartiger ... Ansätzen, dass sie der Resistenz von Antibiotika bei der ... ...
(Date:1/24/2017)... 2017 Scope of the Report The ... Intermittent Catheter Market (2016-2020)", provides an in-depth analysis of ... by product line. The market also provides an in-depth ... report provides a regional analysis of continence care market, ... , Europe and Rest of ...
(Date:1/23/2017)... WASHINGTON , Jan. 23, 2017 ... to suspend the implementation of the planned 2020 ... PTCB Certification. PTCB originally announced in 2013 that ... part of a road map of program changes ... technician roles in the pharmacy. ...
Breaking Medicine Technology: