Navigation Links
Higher radiation dose does not help lung cancer patients live longer
Date:10/3/2011

Miami Beach, Fla., October 3, 2011 A higher dose of radiation (74 Gy) does not improve overall survival for non-small cell lung cancer that has spread to the lymph nodes, compared to the standard radiation dose (60 Gy), according to an interim analysis of a late-breaking randomized study presented at the plenary session, October 3, 2011, at the 53rdAnnual Meeting of the American Society for Radiation Oncology (ASTRO).

"Most radiation oncologists and lung cancer specialists are surprised by this finding. Although the optimal radiation dose for lung cancer patients has not been tested in a randomized phase III trial for over 30 years, most believed that higher doses of radiation cured more patients with lung cancer," Jeffrey Bradley, MD, a radiation oncologist at the Washington University School of Medicine in St. Louis, said.

The goal of the phase III trial was to find out if high doses of radiation improve survival and also if the chemotherapy drug, Cetuximab, increases survival among stage III non-small cell lung cancer patients. Investigators randomized 423 patients to different doses of radiation therapy and concurrent chemotherapy of paclitaxel and carboplatin with or without Cetuximab. Patients received one of four treatment arms: standard-dose (60 Gy) versus high-dose (74 Gy) radiation therapy and to chemotherapy with or without Cetuximab.

Two types of external beam radiation therapy were used during the trial: three-dimensional conformal radiation therapy (3D-CRT), that uses special imaging techniques to precisely tailor the radiation beams so that nearby normal tissue receives less radiation; and intensity modulated radiation therapy, (IMRT), a newer, specialized form of 3D-CRT which further limits the radiation dose to the normal tissues.

Based on the study's early findings, patients who received the higher dose of radiation (74 Gy) did not have better survival rates than those receiving the standard dose (60 Gy); therefore, the two arms of the trial which used high-dose radiation therapy were closed to patient accrual.

"The trial provides class I evidence that the standard dose of radiation therapy for stage III lung cancer should remain at its existing level of (60 Gy) and doses as high as 74 Gy are not better in curing Stage III lung cancer," Dr. Bradley said. "We are not sure why this is the case and our data is still being carefully reviewed."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Minorities Not Treated at Higher-Quality Centers
3. Black Women at Higher Risk of Birth-Related Heart Problem
4. Risk of Childhood Obesity Higher Among Minorities
5. Death After Discharge Rates Higher in Elderly ICU Patients
6. Anti-depressants bring higher risk of developing cataracts: UBC-Vancouver Coastal Health research
7. K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity
8. Do Liberals, Atheists Have Higher IQs?
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. More Money, Increased Participation and Higher Nutritional Standards for School Meals
11. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... September 26, 2017 , ... “Childhood Memories of a Virginia Wanderer”: ... and help them relive their own youth. “Childhood Memories of a Virginia Wanderer” is ... US Navy for nine years. He received his BS from Idaho State University ...
(Date:9/26/2017)... ... ... story of the author and the exciting times this adventurer has lived through. “The Tour ... and the subject of the book. , “Quickly slapping a large smile on my ... off as a part of the adventure tour, an “added bonus” story they would never ...
(Date:9/26/2017)... ... ... Ceebie”: a tool families can use to teach children about the love of God. ... a devoted follower of Jesus Chris who is married with one son. Originally from ... children but also to glorified God in everything he does.” --G.S. White , Published by ...
(Date:9/25/2017)... ... ... Your World Insurance Services, a long-time Redlands insurance and financial services firm, ... owner Stacy Boyle to give back to the many charitable organizations that help families ... school,” said Ms. Boyle. “My father passed away without life insurance, and my mother, ...
(Date:9/25/2017)... ... September 25, 2017 , ... Sensogram Technologies Inc. today ... detection smart watch. VitalBand provides elite level fall detection, automatically calls any ... help arrives quickly. Plus, it’s a fully functioning smart watch and activity ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)...  Medical professionals are expected to continuously ... their patients. Medical simulations offer clinicians the ... Simulation provides a safe method for teaching ... refine techniques and build confidence, without putting ... such as augmented reality, will now provide ...
(Date:9/5/2017)... another milestone in their continued growth and success of the company.  Xyntek has ... engagements regionally.  ... at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office will support the ... In addition to Xyntek,s headquarters ...
(Date:9/1/2017)... Like Us ( https://explorerslikeus.com/ ) is embarking on "An American ... these experiences as part of Life Environments™, a new technology ... ... beats a walk, jog or simply playing in a garden ... next best thing when getting there isn’t possible. Life Environments™ ...
Breaking Medicine Technology: