Navigation Links
Higher radiation dose does not help lung cancer patients live longer
Date:10/3/2011

Miami Beach, Fla., October 3, 2011 A higher dose of radiation (74 Gy) does not improve overall survival for non-small cell lung cancer that has spread to the lymph nodes, compared to the standard radiation dose (60 Gy), according to an interim analysis of a late-breaking randomized study presented at the plenary session, October 3, 2011, at the 53rdAnnual Meeting of the American Society for Radiation Oncology (ASTRO).

"Most radiation oncologists and lung cancer specialists are surprised by this finding. Although the optimal radiation dose for lung cancer patients has not been tested in a randomized phase III trial for over 30 years, most believed that higher doses of radiation cured more patients with lung cancer," Jeffrey Bradley, MD, a radiation oncologist at the Washington University School of Medicine in St. Louis, said.

The goal of the phase III trial was to find out if high doses of radiation improve survival and also if the chemotherapy drug, Cetuximab, increases survival among stage III non-small cell lung cancer patients. Investigators randomized 423 patients to different doses of radiation therapy and concurrent chemotherapy of paclitaxel and carboplatin with or without Cetuximab. Patients received one of four treatment arms: standard-dose (60 Gy) versus high-dose (74 Gy) radiation therapy and to chemotherapy with or without Cetuximab.

Two types of external beam radiation therapy were used during the trial: three-dimensional conformal radiation therapy (3D-CRT), that uses special imaging techniques to precisely tailor the radiation beams so that nearby normal tissue receives less radiation; and intensity modulated radiation therapy, (IMRT), a newer, specialized form of 3D-CRT which further limits the radiation dose to the normal tissues.

Based on the study's early findings, patients who received the higher dose of radiation (74 Gy) did not have better survival rates than those receiving the standard dose (60 Gy); therefore, the two arms of the trial which used high-dose radiation therapy were closed to patient accrual.

"The trial provides class I evidence that the standard dose of radiation therapy for stage III lung cancer should remain at its existing level of (60 Gy) and doses as high as 74 Gy are not better in curing Stage III lung cancer," Dr. Bradley said. "We are not sure why this is the case and our data is still being carefully reviewed."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Minorities Not Treated at Higher-Quality Centers
3. Black Women at Higher Risk of Birth-Related Heart Problem
4. Risk of Childhood Obesity Higher Among Minorities
5. Death After Discharge Rates Higher in Elderly ICU Patients
6. Anti-depressants bring higher risk of developing cataracts: UBC-Vancouver Coastal Health research
7. K-State Study Finds Abundance of Food Stores, Not Lack of Them, Puts Low-Income Women In Small Cities at Higher Risk of Obesity
8. Do Liberals, Atheists Have Higher IQs?
9. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
10. More Money, Increased Participation and Higher Nutritional Standards for School Meals
11. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... ... property (IP) to its specialty academic programs. , Answering to the increasing demand ... certificate programs in health law, and environmental and land use law. ,  , ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... one that has a significant negative impact on long-term patient survival, reports a ... The results, published online this week in the Journal of Thoracic and Cardiovascular ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, ... public. , Dr. Maisel, founder of Retina Group of New York , ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of Life Science ... the organization has earned its ISO 13485 certification, indicating the company’s quality control ... rules and policies associated with ISO quality standard 13485. , BSI Group ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... campers a multitude of activities from daily practices, arts & crafts, discussions, and ... Directors Amber East-D’Anna and Christy Evans have combined backgrounds in kids’ yoga, collegiate ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016  Diana Russell suffers from ... organs from the inside out.  This disease has put ... on her children and grandchildren to leave her home.  ... Diana,s family cannot haul the wheelchair.  So if there ... car, and Diana is left to wait for the ...
(Date:5/24/2016)... -- NxStage Medical, Inc. (Nasdaq: NXTM ), a ... today announced that Jeffrey H. Burbank , Chief ... of investor conferences. Where applicable, a webcast of the ...   ... Friday, June 10, 2016 1:30 p.m. ET ...
(Date:5/24/2016)... BioMarketing as senior vice president of sales, announced Andrea Heslin Smiley , VMS ... company,s business development and sales team, exploring new opportunities for VMS to empower patients ... ... ... ...
Breaking Medicine Technology: