Navigation Links
Higher mortality in postmenopausal women with RA and anti-CCP antibodies
Date:12/22/2013

New research shows mortality rates are two times higher in postmenopausal women with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Findings published in the American College of Rheumatology (ACR) journal Arthritis & Rheumatism, soon to be called Arthritis & Rheumatology, indicate the higher mortality rates persisted after adjusting for age, positive rheumatoid factor, positive antinuclear antibodies (ANA) and disease modifying anti-rheumatic drug (DMARD) use.

According to the ACR, RA affects 1.3 million adults in the U.S. with 75% of those being women. Previous studies report that RA patients have mortality rates 1.5-fold higher than healthy controls. Medical evidence suggests that excess mortality is mainly caused by cardiovascular disease and is greater in groups with existing RA compared to those newly diagnosed.

However, observational data indicate that methotrexate may reduce cardiovascular disease and mortality.

For the present study researchers from the University of Pittsburgh, led by Drs. Lewis Kuller and Larry Moreland, measured anti-CCP, rheumatoid factor and ANA in close to 10,000 women who self-reported RA as part of the Women's Health Initiative (WHI)clinical trials and observational study of postmenopausal women, conducted by the National Institutes of Health (NIH). Participants included in the present research had a mean age of 64 years with 65% white, 25% black and 10% Hispanic.

Results show that anti-CCP was prevalent in 8.1% of the group, of whom 58% reported DMARD use during follow-up. Only 7.3% of the remaining 9,179 women with self-report RA, but negative anti-CCP, were using DMARDs. During the 10-year study period, 13% of women died14% who self-reported RA at the start of the study and follow-up; 16% who reported RA at baseline; and 11% who reported RA at follow-up.

Further analysis determined that cardiovascular disease, including coronary heart disease and stroke, and cancer were the main cause of death among women with RA. Women with positive anti-CCP had a substantially higher mortality risk that was independent of DMARD use, including methotrexate, and modifiable risk factors (obesity, smoking) associated with mortality.

"Our study is the first large longitudinal study to evaluate anti-CCP, RF, risk factors and mortality," said Dr. Kuller. "Further investigation to determine specific causes of excess mortality, particularly among RA patients with positive anti-CCP, are needed."


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Marijuana consumption in Washington state is higher than previously estimated, study finds
2. Higher case load lowers cost of repairing bones that protect eye
3. Information Technology Alliance (ITA) Member Altec Increases Involvement at the 2013 ITA Fall Collaborative with Higher Attendance and Planning Team Participation
4. Increasing the number of insured patients is not tied to higher ICU usage in Massachusetts
5. Costs Per Claim of Medical Care for Injured Workers in Indiana Higher Than Most States and Rising, New Study Says
6. Study reveals higher levels of control and support at work increases wellbeing
7. New Venture Puts Higher Education in the Mix With Biotech Industry
8. CO-OPs Have Generally Higher Premiums, Atlantic Information Services Analysis Finds; Could Pose Challenge in Attracting Members
9. Study: Higher rates of diabetes, hypertension, heart disease and stroke found in food desert
10. Teens in child welfare system show higher drug abuse rate
11. Is left-handedness higher among those suffering from psychosis?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... that serves communities throughout north Jersey and the New York metropolitan region, is ... provide regional support for homeless families. , At present, more than two and ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Vanderbeck Agency, a Long ... Nassau County region, is embarking on a combined charity effort with the Great Neck ... the last 25 years, the Great Neck Breast Cancer Coalition has worked to support ...
(Date:3/22/2017)... City, OK (PRWEB) , ... March 22, 2017 ... ... offering insurance and financial planning services to regional families and business owners, is ... meaningful support to young people in the area. , A growing number of ...
(Date:3/22/2017)... ... 22, 2017 , ... The Zabbia Insurance Agency, a Long ... business owners in the greater Nassau County area, is embarking on a cancer ... 3 minutes, someone in America is diagnosed with blood cancer. Every 9 minutes, ...
(Date:3/22/2017)... ... March 22, 2017 , ... Martin J. Mitchell Insurance, ... to communities throughout central Ohio, is initiating a charity drive to raise support ... of Defense and the Veteran's Brain Injury Center conclude that more than one ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... FinancialBuzz.com News Commentary ... is strongly contributing to job creation. A recent report ... for the cannabis industry, projects that by 2020, the ... million jobs for American workers. The legal cannabis market ... is projected to grow at a compound annual growth ...
(Date:3/22/2017)... LUND, Sweden , March 22, 2017 ... Saleh and Mr. Ed Tumaian , two global executive ... Tumaian will be joining the Operational Leadership Team and will report ... ... Saleh comes to TFS with 10 years of medical and ...
(Date:3/22/2017)... March 22, 2017 EMD Serono, the biopharmaceutical business ... the U.S. and Canada , today announced ... poster presentation session at the 65 th Annual Pacific ... California on March 24 th .   ... real-world database collected from July 2009 to December 2015 containing ...
Breaking Medicine Technology: