Navigation Links
Higher incidence of seizures seen in children with H1N1 virus compared to seasonal flu

A recent study by researchers at the University of Utah determined that the 2009 pandemic influenza A (H1N1) caused a higher rate of neurological complications in children than the seasonal flu. The most common complications observed were seizures and encephalopathy. Full details of the study, the most extensive evaluation of neurological complications following H1N1 flu in children, are published in the September issue of Annals of Neurology, a journal of the American Neurological Association.

The H1N1 virus (swine flu) was identified in Mexico and the U.S. in April 2009 and quickly spread worldwide, prompting the World Health Organization (WHO) to declare the novel influenza A virus a pandemic. According to estimates from the Centers for Disease Control and Prevention (CDC), 43 million to 89 million Americans were infected with H1N1 between April 2009 and April 10, 2010, with approximately 14 million to 28 million of those cases in children 17 years of age and younger. On August 10, 2010 the WHO International Health Regulations Emergency Committee officially declared an end to the 2009 H1N1 pandemic.

In their retrospective study, Josh Bonkowsky, M.D., Ph.D., and colleagues examined neurological complications in children with H1N1 compared to the seasonal flu. Children (younger than 19 years of age) who were hospitalized with H1N1 and neurological complications between April 1 and November 30, 2009 were included in the study. In the comparison group, the research team used records of children hospitalized with seasonal flu and neurological complications from July 1, 2004-June 30, 2008. Neurological complications observed included seizures, febrile seizures, status epilepticus, encephalopathy, encephalitis, myositis, myalgia, aphasia, ataxia, neuropathy, Gullain-Barre syndrome, or other focal neurological complaints.

Researchers identified 303 children who were hospitalized with 2009 H1N1 of which 18 experienced neurological complications. Eight-three percent of these pediatric patients had an underlying medical conditionprimarily neurological issues (66%). The research team found the most common neurologic symptoms in this group were seizures (67%) and encephalopathy (50%). More than half of those children who experienced seizures presented in a life-threatening state known as status epilepticus, where continuous seizure activity occurs for more than 5 to 30 minutes1.

The comparison group included 234 children who were hospitalized for seasonal flu with 16 patients experiencing neurological issues. In the seasonal flu cohort only 25% patients had underlying medical conditions. The researchers also noted that none of the patients with seasonal flu and neurological complications had encephalopathy, aphasia, or focal neurological deficits.

Compared to seasonal influenza, patients with H1N1 were more likely to have abnormal electroencephalogram (EEG) findings. "We found that more pediatric H1N1 patients had neurological deficits and required ongoing treatment with anti-epileptic medications upon discharge from the hospital," commented Dr. Bonkowsky.

Additionally, researchers found the use of steroids or intravenous immunoglobulin was not beneficial in the treatment of encephalopathy. "The absence of proven treatments for influenza-related neurological complications underlines the importance of vaccination," said Dr. Bonkowsky. For protection against the flu, the CDC recommends yearly flu vaccination and the U.S. 2010-2011 seasonal influenza vaccine will protect against an H3N2 virus, influenza B, and the 2009 H1N1 virus.


Contact: Dawn Peters

Related medicine news :

1. Absent Father Might Mean Earlier Puberty for Higher-Income Girls
2. In Vitro Fertilization Success Rate Higher in Spring, Study Suggests
3. New nuclear breast imaging technologies associated with higher cancer risks
4. Drugs used to treat osteoporosis not linked with higher risk of esophageal cancer
5. Tattooing linked to higher risk of hepatitis C: UBC study
6. Black Teens May Need Higher Vitamin D Supplementation
7. Regional variation in health-care spending and utilization higher in Medicare than private sector
8. Study links more time spent sitting to higher risk of death
9. Study Suggests Higher Cancer Rate Among IVF Babies
10. Extremely obese children have 40 percent higher risk of reflux disease of esophagus
11. Study: Higher-protein diets support weight loss, but may lower bone density in postmenopausal women
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: