Navigation Links
Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
Date:7/29/2009

DALLAS July 30, 2009 The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

The finding, reported online and in the August edition of Antimicrobial Agents and Chemotherapy, is particularly important for those living in societies plagued by obesity, said Dr. Tawanda Gumbo, associate professor of internal medicine at UT Southwestern and the study's lead author.

"What really drives the variability of this particular drug is patient weight and gender, so in our simulations we took that into account," Dr. Gumbo said. "What we found is that we're really using doses for very skinny people 105 to 110 pounds. I haven't met many adults who are at that weight."

About one-third of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB, and as many as 2 million people die from the disease each year. TB, which is the leading cause of death among people infected with HIV/AIDS, kills more people than any other disease caused by a single infectious agent, according to the National Institutes of Health. Treatment usually lasts six to 12 months and includes a combination of antibiotics such as Pyrazinamide, the drug examined in this study.

Because treatment typically includes multiple drugs, introducing new ones to existing regimens has made it harder to identify which, if any, of the drugs are working at the current dosage levels. Researchers also have struggled to identify the needed dosage as well as exactly where in the body these drugs work to combat the bacterium.

The new model developed at UT Southwestern uses cultured cells to gauge the effectiveness and proper dosage of anti-tuberculosis drugs.

"With this model, we can directly test molecules that have the potential to shorten therapy and go straight to coming up with the dos
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Connectyx Technologies Holdings Group, Inc. to Begin Process to Become Fully Reporting and Up List to a Higher Exchange - As Stated on Wallstreetcorner.com
2. Beta-Blockers Tied to Higher Cataract Risk
3. Deaths, Injuries Increase With Higher Speed Limits
4. Lower IQ Linked to Higher Risk of Heart Deaths
5. Children of undocumented parents may be at higher developmental risk
6. Mothers of children with autism have higher parental stress, psychological distress
7. Rate of Breast Cancer in Italy Significantly Higher Than Previously Reported
8. Obese Get Higher Doses of Radiation for X-Rays
9. Low Blood Sugar in Hospital Tied to Higher Death Risk for Diabetics
10. Abused Kids Face Higher Cancer Risk
11. Study Finds Skin Cancer Rates Higher Among Athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... 03, 2015 , ... First Choice Emergency Room , the largest network ... as the new Medical Director of its Frisco facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:7/3/2015)... ... July 03, 2015 , ... Yisrayl Hawkins, Pastor and ... this week that he says will reveal biblical truth and expose popular lies regarding ... Your Bible Say Don’t Have Sex”, immediately goes into the core of the subject ...
(Date:7/3/2015)... ... 2015 , ... The Celebrity Dresses is currently running a promotion through July ... will have the opportunity to get 10% discount on orders that are over $100. ... have to use coupon codes or remember redemption codes. , There is a ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its ... the Lone Star State. The premium frozen yogurt chain was listed as #22 on the ... 19 in the Village at Bachman Lake, is located at:, 3701 W. Northwest Highway, STE ...
(Date:7/2/2015)... ... ... Following the recent report by JAMA Internal Medicine published on ... Samir Becic emphatically declared a war on obesity in the United States. , "Obesity ... must understand the magnitude of this discovery. For that reason, I am declaring, along ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4
... by a jackal in Bihar's Gopalganj district, but there are ... patients. ,In the last two days, ... and children - in half a dozen villages under the ... ,The injured are being treated at different hospitals ...
... bio-technology pharma company from Zurich, Switzerland has developed a ... months at a time . ,The drug ... blood pressure by contracting vessels, by inducing antibodies. ... CYT006-AngQb developed by Cytos Biotechnology reduced systolic blood pressure ...
... in that US doctors tend to prescribe unwanted, even possibly ... the name of lecture assignments. ,Lawmakers are ... to disclose payments made to doctors and also keep within ... earn more money from drug makers than doctors in any ...
... heiress Paris Hilton under house arrest, has defended his ... from a 'life-threatening' psychiatric condition called decompensating. ... mental state to the point of severe depression, nervousness ... Simple Life star's condition was even more complicated because ...
... Louis University has found that a patient's emotional state plays ... surgery. ,After hip surgery, two tests are ... is a clinical measure of hip function given by the ... considers a wide variety of factors in determining the overall ...
... at the University of York and Hull York Medical School ... folate. ,Folate is a vitamin that comes ... and peas. Fortified cereal products, sunflower seeds as well as ... been claiming that adding folate to bread or flour will ...
Cached Medicine News:Health News:US Lawmakers Considering Legislation to Restrict Payments by Drug Companies to Doctors 2Health News:US Lawmakers Considering Legislation to Restrict Payments by Drug Companies to Doctors 3Health News:Emotions Play 'significant Role' in Recovery from Hip Surgery 2
(Date:7/2/2015)... , July 2, 2015 ... as ,Friendly Aedes aegypti , , reduced ... Brazil by 95%, well below ...      (Logo: http://photos.prnewswire.com/prnh/20150630/227348LOGO) , The journal PLOS ... trial of Oxitec,s genetically engineered mosquitoes. The results showed ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/nlfg34/cancer ) has announced the ... by Application - Forecast to 2020" report to their offering. ... $13.1 Billion in 2020 from an estimated $7.1 Billion in 2015, ... dominated by North America , followed by ... of the World (RoW). The cancer diagnostics market in ...
(Date:7/2/2015)... Pharma Major Lupin Limited today announced the acquisition of ... subject to certain closing conditions. The acquisition marks ... 765 billion in sales, placing it as one of the ... Health). For over a decade, Russian pharmaceutical market recorded double ... Russia to be one of the ...
Breaking Medicine Technology:Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 3Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2Lupin Acquires Biocom in Russia 2Lupin Acquires Biocom in Russia 3
... 1, 2011 Hologic, Inc. (NASDAQ: HOLX ) ... Financial Officer, will be presenting at the Nasdaq OMX 27th ... 11:15am (GMT). Interested parties are invited to listen ... the investor section of Hologic,s website at www.hologic.com/investors-overview . ...
... Md., Dec. 1, 2011 The Food and Drug Administration ... products, including a potentially contaminated nasal spray ... unapproved drug sold as a testosterone booster ... alerts were prompted by reports FDA received from health care ...
Cached Medicine Technology:
... Get the equivalent of 7.5 liters out ... will you need two machines for your high-flow ... OXYMIZER Disposable Oxygen-Conserving Devices function like standard conservers, ... flow of oxygen required to saturate a patient. ...
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
... an average 5:1 increase in usage time at ... a standard cannula. , ,The combination of ... oxygen patients a superior alternative to liquid oxygen. ... , ,NOTE: Each ...
Medicine Products: