Navigation Links
Higher-dose RT results in inferior survival in patients with stage III lung cancer
Date:5/29/2013

In a randomized phase III clinical trial conducted by the Radiation Therapy Oncology Group (RTOG), high-dose (HD), compared with standard-dose (SD), radiotherapy (RT) with concurrent chemotherapy (CT) did not improve overall survival of patients with stage III non-small-cell lung cancer (NSCLC).

Philadelphia, PAOf all the patients in the US with lung cancer, the country's leading cause of cancer death, 75 to 80 percent of them have NSCLC, with 30 to 40 percent of those being considered locally advanced (stage IIIA or IIIB). Although RT plus CT has been the standard of care for locally advanced NSCLC, more research has focused on the incorporation of appropriate CT drugs than on revisiting the 60-Gy RT dose established over 30 years ago. Concern over local tumor progression rates near 85 percent following treatment for stage III NSCLC with CT plus conventional RT doses and research results showing increased median survival time associated with a 74-Gy RT dose led to the development of RTOG 0617, which sought to identify the optimal RT dose for the treatment of patients with locally advanced NSCLC. The trial additionally tested the hypothesis that the addition of cetuximab, a drug that targets the epidermal growth factor receptor (EGFR) pathway and has radiation-sensitizing properties, to chemoradiation would lead to improved survival.

The trial randomized 464 patients with pathologically diagnosed unresectable stage IIIA or IIIB NSCLC to SD (60 Gy) or HD (74 Gy) arms. All patients received concurrent CT of weekly paclitaxel and carboplatin, as well as additional cycles of consolidation CT following combined CT and RT.

The trial's final results on radiation dose will be presented Tuesday, June 4 at the American Society of Clinical Oncology 2013 Annual Meeting by Principal Investigator (PI) Jeffrey D. Bradley, M.D., a professor in radiation oncology, and chief of thoracic service at Washington University School of Medicine in St. L
'/>"/>

Contact: Shawn Farley
PR@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cayman Enterprise City’s Overseas Trips to Silicon Valley and Toronto Producing Results
2. Narconon Releases Early Study of Delaware Prison Program, Demonstrating Crime Reduction Consistent with More Recent Narconon Results
3. Integrated stroke care system results in fewer deaths, discharges to long-term care facilities
4. Diversity Focus Announces Results from the 2013 Creative Corridor Community Survey
5. Statins May Hamper Workout Results
6. Diversity Focus Announces Results from 2013 Creative Corridor Survey at News Conference on Thursday, May 23rd at 10:30 a.m.
7. Abutment-Free Sophono Systems Produce Comparable Study Results to Cochlear’s Baha Products, With Fewer Complications
8. Narconon Releases Report on its Very First Narconon Program, the First of 23 Reviews or Evaluations of Results up to 2009
9. Sous Vide Circulating Bath Systems Enable Chefs to Achieve Perfect Results
10. Cellphone Calls During Blood Pressure Readings May Skew Results
11. Injectable Fillers - How to Avoid Nurse Injectors and Get Natural Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... Documented Legacy , a mobile personal ... of its first military memoir about a World War II ... October 1943 and 19 months as a prisoner of war ... the American dream. , From the Top Turret: A ... (Amazon) is a true life story of Gerard Caporaso’s ...
(Date:7/14/2014)... 2014 The Retina Group of ... Hauppauge, NY, has announced the availability of Ozurdex® ... diabetic macular edema (DME) patients. Ozurdex, a corticosteroid ... indication for use in diabetic macular edema. Ozurdex ... for treatment of retinal vascular occlusions and and ...
(Date:7/14/2014)... 14, 2014 According to a recent ... researchers have discovered a connection between women with high ... of infertility. Although doctors have theorized about the role ... first study to provide scientific support. , “Stress, if ... said Dr. Larry Barmat, an OB/GYN who specializes in ...
(Date:7/14/2014)... 2014 Last month Bromell Agency officially ... The webpage features more detailed information on how clients ... RVs, ATVs, and boats in the state of Louisiana. ... feature to the website in order to better educate ... the purpose of the website, which is to display ...
(Date:7/14/2014)... 14, 2014 There’s an old adage that ... The Lash Palette say the products offered in their ... , “You can reserve The Lash Palette for $40,” said ... Store . , Paris explained that the first 1,000 have ... 21. , She went on to point out that her ...
Breaking Medicine News(10 mins):Health News:Mount Laurel-based Documented Legacy to Release Military Memoir of World War II Air Force Vet Who Survived Black Thursday Crash 2Health News:Retina Group of New York Now Offers Long-lasting Ozurdex® Treatment for Diabetic Retinopathy 2Health News:Retina Group of New York Now Offers Long-lasting Ozurdex® Treatment for Diabetic Retinopathy 3Health News:Abington Health Physician Addresses Link Between Stress and Infertility 2Health News:Abington Health Physician Addresses Link Between Stress and Infertility 3Health News:The Lash Palette Preorder Event Has Officially Begun 2
... , , WASHINGTON , Feb. 8 ... showed he has what it takes to win big. Not only does ... own Milk Mustache. The 13th annual winning football Milk Mustache ad runs ...   http://www.newscom.com/cgi-bin/prnh/20100208/AQ51302 ) , The famed running back is the latest superstar ...
... Nev. , Feb. 8 The Whittemore Peterson ... Donnica Moore , a distinguished women,s health expert, as its ... in its efforts to help raise awareness and funding for ... Fatigue Syndrome.   , "We are pleased to have a ...
... ... Health, a joint venture between Humility of Mary Health Partners (HMHP) , NEO ... Ohio,s first and only radiation oncology center with Elekta Volumetric Modulated Arc Therapy (VMAT), ... ...
... , , NORTHBROOK, Ill. , ... a global leader in environmental evaluation and certification, announces ... materials used in consumer and manufactured goods.  These standards ... scientific assessment and broad stakeholder collaboration.   , This ...
... the use of computed tomography (CT scans) in children ... of scans, according to a new study in ... link only) http://www.cmaj.ca/embargo/cmaj091421.pdf . More than 650,000 ... consciousness, amnesia, disorientation and/or vomiting are seen each year ...
... JRS Medical ... that the Company is donating a percentage of all of their January & February 2010 ... employees also are raising funds locally for victims of the tragic earthquake. , ... (PRWEB) February 8, 2010 -- JRS Medical ...
Cached Medicine News:Health News:Reggie Bush Takes Down Reggie Wayne in Battle for the Milk Mustache! 2Health News:Whittemore Peterson Institute Announces Renowned Health Expert as New Spokesperson 2Health News:Partners for Urology Health First in Ohio with New Radiation Therapy Technology 2Health News:Partners for Urology Health First in Ohio with New Radiation Therapy Technology 3Health News:UL Environment to Develop Sustainability Standards For Plastic 2Health News:New CATCH rule to determine need for CT scans in children with minor head injury 2Health News:JRS Medical Raises Funds for Devastated Victims in Haiti 2Health News:JRS Medical Raises Funds for Devastated Victims in Haiti 3
(Date:7/14/2014)... July 14, 2014 CVS/pharmacy ® ... PLATINUM, a premium brand of 100% preservative-free vitamins ... growing family of exclusive CVS/pharmacy store brand products. ... with various benefits, including popular options such as ... women. The radiance PLATINUM line also has more premium options ...
(Date:7/14/2014)... , July 14, 2014 The legalization of ... – as well as a new economic driver – ... to sort out the right response to the will ... intoxicant. At a National Press Club ... a.m., two leading experts in the area of marijuana ...
(Date:7/14/2014)... N.Y. , July 14, 2014 We ... Surgery Center ("OACM") and the Ellicott City Ambulatory Surgery ... of Ellicott City Maryland . ... between Merritt Healthcare and 14 leading Orthopaedics, Sports Medicine, ... Facility will also accommodate the specialties of general surgery ...
Breaking Medicine Technology:CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 2CVS/pharmacy Launches Exclusive radiance PLATINUM Line of Preservative-Free Vitamins and Supplements 3NPC Newsmaker Program: Interpreting smoke signals from the marijuana skirmish line 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: