Navigation Links
Higher cancer rates found in liver transplant patients receiving cyclosporine for immunosuppression
Date:6/24/2010

t least one de novo cancer.

The researchers observed that CsA in comparison to TAC treatment is the most important risk factor for de novo malignancy after liver transplant. This higher cancer risk was not, however, found in all CsA treated patients, but CsA specifically enhanced development of de novo cancer in patients transplanted in more recent years (2005-2007), and in younger patients (less than 50 years of age). In addition, CsA treatment particularly resulted in more aggressive types of cancer compared to TAC, with a 1-year survival rate less than 30%.

The reason for the increased cancer rates among CsA recipients is believed to be the fact that from January 2005, CsA dosing based on the conventional C0 level monitoring was replaced by dosing based on C2 level monitoring in all liver transplant patients. As this was the only major change in the CsA treatment in the recent study period, the team concludes that the C2 monitoring strategy was the reason for the increased early de novo cancer risk.

"Strikingly, CsA treated patients transplanted from 2005 on showed a 9.9-fold higher de novo cancer risk in the early phase after liver transplant compared to patients treated with TAC. These data indicate that only the specific CsA treatment used in recent years was associated with a higher risk for early development of de novo cancer," said research team leader Herold Metselaar, M.D., Ph.D. "We also observed that, compared with TAC treated patients, CsA treated patients had a 2.5-times higher risk to develop more aggressive cancer types that do not belong to the non-melanoma skin cancer and post-transplant lymphoproliferative disorder (PTLD) categories, indicating that CsA is not only associated with a higher early de novo cancer risk, but also with cancer types having a worse prognosis."

In this month's editorial, Julie Thompson, M.D., suggests that further study is required, stating, "Metselaar and colleagues draw much-need
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Women with polycystic ovary syndrome have higher BPA blood levels
2. Higher Testosterone Tied to Heart Trouble in Older Men
3. Higher levels of vitamin B6, common amino acid associated with lower risk of lung cancer
4. Higher anxiety, depression among women may have basis in cell signals
5. Uninsured Americans have 50 percent higher odds of dying in hospital from heart attack or stroke
6. Teen automobile crash rates are higher when school starts earlier
7. Lack of private insurance contribute to higher deaths among black heart transplant patients
8. Alcohol-related death rates much higher in deprived areas of England and Wales
9. Suicide Risk May Be Higher in Senior Facilities
10. Higher oxygen levels improve preterm survival, increase risk for eye condition
11. Higher blood pressure found in people living in urban areas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... Pleasant Prairie, WI (PRWEB) June 03, 2015 ... suited for regulated industries such as government, finance and ... any organization that wants reliable access control to enhance ... smart card keyboard requires the secondary authentication of a ... In addition to the smart-chipset card reader, the ...
(Date:6/2/2015)... 02, 2015 Aidan Booth And ... to public yesterday, and has since received rave ... product reviewer Tiffany Hendricks has weighed in with ... the course on her website HonestyFirstReviews.com. , "These ... Internet marketers looking to hone their business skills ...
(Date:6/2/2015)... VA (PRWEB) June 02, 2015 ... Erin Wallace, 571-319-9594 (cell) , Email: ewallace(at)mentalhealthamerica(dot)net , ... of New Mental Health Legislation at MHA Annual ... , What: Rep. Murphy to address the Mental ... for the long-awaited updated version of the Helping ...
(Date:6/2/2015)... MI (PRWEB) June 02, 2015 On ... “Fighting Addiction Together” in the Hall of Legends at ... receiver and motivational speaker Herman Moore, the goal of ... of addiction in today’s society, highlight the benefits of ... inform the attendees about the options that are available ...
(Date:6/2/2015)... Highly qualified dental care specialists inside the leading Romanian ... in the dental tourism industry in Europe. As dentistry continues ... a full range of superior dental services in its high-tech ... Partnered with a top medical tourism agency , the ... has earned a reputation as an influential provider for its ...
Breaking Medicine News(10 mins):Health News:Introducing the New CHERRY JK-A0100EU Keyboard with Integrated Smart Card Reader for Access Control Security 2Health News:100K Factory - Review of Aidan Booth and Steve Clayton's New IM System Published 2Health News:Congressman Tim Murphy to Unveil Details of New Mental Health Legislation at MHA Annual Conference Thursday 2Health News:Rehabilitation Facility Graduate Shares Her Story at "Fighting Addiction Together" Conference 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3
... ... , ... IntertechPira is pleased to announce the dates and location for the 8th Color Cosmetics Summit. ... on October 18 - 20, this event promises to provide attendees with several networking opportunities, ...
... , Held at 2,000 U.S. locations during National ... Feb. 3 With an economy that might cause some ... decay being the most prevalent chronic disease in America,s children, the ... the eighth consecutive year in a national campaign to extend necessary ...
... N.C. , Feb. 3 The Steritech Group., Inc., ... Leavitt Partners, to advise the company on food safety and regulatory ... its clients ahead of the curve and manage the complex challenge ... O. Leavitt , former Secretary of Health and Human Services and ...
... , SAN MATEO, Calif. , Feb. 3 ... its Medicare Advantage Plan in Northern California exceeded company ... launch in four local counties. Eligible individuals may continue to join ... Medicare members in Southern California and Arizona , ...
... , The ACCP and FIRS Elevate ... , NORTHBROOK, Ill. , Feb. 3 During the ... Physicians (ACCP) and other members of the Forum of International Respiratory Societies ... the awareness of lung cancer in terms of prevalence and prevention, as ...
... restrictive, obsessive eating habits , WEDNESDAY, Feb. 3 (HealthDay News) ... what Ryan Kemp,s parents faced when he was a child. , ... polish off box after box and grow agitated if his parents ... entire jars of tartar sauce. , At various times, Ryan was ...
Cached Medicine News:Health News:Dates Announced for IntertechPira's 8th Color Cosmetics Summit 2Health News:Eighth Annual 'Give Kids A Smile' Day Provides Free Dental Care to Children 2Health News:Eighth Annual 'Give Kids A Smile' Day Provides Free Dental Care to Children 3Health News:Steritech Retains Leavitt Partners to Advise the Company on Emerging Food Safety Concerns and Regulation 2Health News:SCAN Health Plan's Northern California Launch Embraced by Local Seniors 2Health News:Lung Cancer: Large Impact, Little Funding 2Health News:Lung Cancer: Large Impact, Little Funding 3Health News:Lung Cancer: Large Impact, Little Funding 4Health News:Mealtime a Challenge for Some With Autism 2Health News:Mealtime a Challenge for Some With Autism 3
(Date:6/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/w3n5p6/drug_delivery_in ) ... report "Drug Delivery in Central Nervous System ... their offering. The delivery of drugs ... in the treatment of neurological disorders. Drugs may ... systematically (e.g., by intravenous injection) for targeted action ...
(Date:6/2/2015)... 2015 The Canadian Society for Vascular Surgery (CSVS) ... or procedures that are commonly ordered but not ... Choosing Wisely Canada.  The list identifies five (5) ... patients and physicians about what care is really ... Surgery,s list identified the following five (5) recommendations: ...
(Date:6/2/2015)... DUBLIN , June 02, 2015 Research and ... "Picture Archiving and Communication Systems (PACS) - Global Strategic ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2014 ...
Breaking Medicine Technology:Global Drug Delivery in Central Nervous System Diseases Report 2015-2024 - Technologies, Markets and Companies 2Global Drug Delivery in Central Nervous System Diseases Report 2015-2024 - Technologies, Markets and Companies 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 2As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 4Picture Archiving and Communication Systems (PACS) - Global Strategic Business Report 2015: User Demand Favors Integrated RIS/PACS Solutions 2
... , DEFUNIAK SPRINGS, Fla., Nov. 11 Professional Products, ... for nearly five decades, today announced its innovative new ... knee splint with a breathable, anti-migration wrap, the PKS ... from pain and edema in treating post-operative repairs, ligament ...
... WellTek/MedX Group, health, fitness and wellness companies, today announced ... facilitate becoming an SEC reporting company. , ... a wholly owned subsidiary of an SEC reporting public ... name to WellTek Incorporated. As a result of ...
Cached Medicine Technology:Knee Splint's Multi-Compartment Technology Speeds Rehabilitation from Injuries 2WellTek/MedX Group Completes Major Reorganization 2
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
Hook design lifts and separates tissue for efficient dissection. Cautery action facilitates immediate control of bleeders....
The Bair Hugger Model 505 provides safe, quiet and effective warming to patients around the world....
Medicine Products: