Navigation Links
Higher anxiety, depression among women may have basis in cell signals
Date:6/15/2010

There may be a biological reason why depression and other stress-related psychiatric disorders are more common among women compared to men. Studying stress signaling systems in animal brains, neuroscience researchers found that females are more sensitive to low levels of an important stress hormone and less able to adapt to high levels than males.

"This is the first evidence for sex differences in how neurotransmitter receptors traffic signals," said study leader Rita J. Valentino, Ph.D., a behavioral neuroscientist at The Children's Hospital of Philadelphia. "Although more research is certainly necessary to determine whether this translates to humans, this may help to explain why women are twice as vulnerable as men to stress-related disorders."

The research appears online today in Molecular Psychiatry. The study's first author is Debra A. Bangasser, Ph.D., a fellow in Valentino's laboratory.

It has long been recognized that women have a higher incidence of depression, post-traumatic stress disorder, and other anxiety disorders, said Valentino, but underlying biological mechanisms for that difference have been unknown. Her research focuses on corticotropin-releasing factor (CRF), a hormone that organizes stress responses in mammals.

Analyzing the brains of rats that responded to a swim stress test, Valentino's team found that in female rats, neurons had receptors for CRF that bound more tightly to cell signaling proteins than in male rats, and thus were more responsive to CRF. Furthermore, after exposure to stress, male rats had an adaptive response, called internalization, in their brain cells. Their cells reduced the number of CRF receptors, and became less responsive to the hormone. In female rats this adaptation did not occur because a protein important for this internalization did not bind to the CRF receptor.

"This is an animal study, and we cannot say that the biological mechanism is the same in people," said Valentino, adding that other mechanisms play a role in human stress responses, including the actions of other hormones. However, she added, "researchers already know that CRF regulation is disrupted in stress-related psychiatric disorders, so this research may be relevant to the underlying human biology."

Furthermore, said Valentino, much of the previous research on stress disorders in animal models used only male rodents, so important sex differences may have gone undetected. "Pharmacology researchers investigating CRF antagonists as drug treatments for depression may need to take into account gender differences at the molecular level," she said.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Severe complications of diabetes higher in depressed patients
2. Ambidextrous Children at Higher Risk for Learning Problems
3. Ecstasy Users at Higher Risk of Sleep Apnea
4. The Reid Bill and What We Know: Higher Taxes and Less Capital - Higher Health Costs and Red Tape for Small Business
5. UTMB study identifies women at higher risk of significant bone loss on injectable birth control
6. Heavier Sons Tied to Higher Death Risk for Parents
7. Study finds higher risk of stillbirth in women with fibroids
8. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
9. Minorities Not Treated at Higher-Quality Centers
10. Black Women at Higher Risk of Birth-Related Heart Problem
11. Risk of Childhood Obesity Higher Among Minorities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
Breaking Medicine Technology: