Navigation Links
Higher anxiety, depression among women may have basis in cell signals
Date:6/15/2010

There may be a biological reason why depression and other stress-related psychiatric disorders are more common among women compared to men. Studying stress signaling systems in animal brains, neuroscience researchers found that females are more sensitive to low levels of an important stress hormone and less able to adapt to high levels than males.

"This is the first evidence for sex differences in how neurotransmitter receptors traffic signals," said study leader Rita J. Valentino, Ph.D., a behavioral neuroscientist at The Children's Hospital of Philadelphia. "Although more research is certainly necessary to determine whether this translates to humans, this may help to explain why women are twice as vulnerable as men to stress-related disorders."

The research appears online today in Molecular Psychiatry. The study's first author is Debra A. Bangasser, Ph.D., a fellow in Valentino's laboratory.

It has long been recognized that women have a higher incidence of depression, post-traumatic stress disorder, and other anxiety disorders, said Valentino, but underlying biological mechanisms for that difference have been unknown. Her research focuses on corticotropin-releasing factor (CRF), a hormone that organizes stress responses in mammals.

Analyzing the brains of rats that responded to a swim stress test, Valentino's team found that in female rats, neurons had receptors for CRF that bound more tightly to cell signaling proteins than in male rats, and thus were more responsive to CRF. Furthermore, after exposure to stress, male rats had an adaptive response, called internalization, in their brain cells. Their cells reduced the number of CRF receptors, and became less responsive to the hormone. In female rats this adaptation did not occur because a protein important for this internalization did not bind to the CRF receptor.

"This is an animal study, and we cannot say that the biological mechanism is the same in people
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Severe complications of diabetes higher in depressed patients
2. Ambidextrous Children at Higher Risk for Learning Problems
3. Ecstasy Users at Higher Risk of Sleep Apnea
4. The Reid Bill and What We Know: Higher Taxes and Less Capital - Higher Health Costs and Red Tape for Small Business
5. UTMB study identifies women at higher risk of significant bone loss on injectable birth control
6. Heavier Sons Tied to Higher Death Risk for Parents
7. Study finds higher risk of stillbirth in women with fibroids
8. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
9. Minorities Not Treated at Higher-Quality Centers
10. Black Women at Higher Risk of Birth-Related Heart Problem
11. Risk of Childhood Obesity Higher Among Minorities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... estimated that as many as 10 million older Americans ... loneliness and isolation. , However, new research a ... older Americans for six years found that Internet ... depression by more than 30 percent. , "That,s a ... University professor of telecommunication, information studies and media who ...
(Date:4/17/2014)... CHICAGO, IL, April 17, 2014-- Colic affects about one ... accounts for numerous pediatric visits during the first several ... of colic symptoms was showing promise; however, the April ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics ... probiotic L reuteri for infant colic ...
(Date:4/17/2014)... (BUSM) have discovered that the anti-seizure drug ezogabine, ... findings, reported in the American Journal of ... more effective treatments for alcoholism. , Excessive consumption ... of illness and death in the U.S. and ... productivity of workers and necessitating huge health care ...
(Date:4/17/2014)... researchers at UC Davis has shown that the cyclin ... cell division, also boosts the mitochondrial activity to power ... has been shown to perform both jobs. This newfound ... control cellular energy production, potentially advancing cancer care and ... the journal Developmental Cell . , "These proteins ...
(Date:4/17/2014)... international research team led by Cesar A. Arias, M.D., ... at Houston (UTHealth) has identified a new superbug that ... report appeared in the April 17 issue of ... new superbug is part of a class of highly-resistant ... MRSA, which is a major cause of hospital and ...
Breaking Medicine News(10 mins):Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2
... ... Sufferers , ... March 30, 2010 -- Those with aching backs might want to look at their home ... color schemes and price range, but many don,t take time to consider products that can ...
... ... ... Tahitian Noni International (TNI) announced that their 2011 International Leadership Conference would ... of the most luxurious cruise ships in the world. The announcement was received with such ...
... ... improved longevity , ... YORK (PRWEB) March 30, 2010 -- CogniFit™, Inc., a leading maker of Brain Fitness ... longevity, author and speaker, is now an official spokesperson for CogniFit. Berg, who is ...
... ... For New Web Hosting Sign-ups , ... Vancouver, Canada (PRWEB) March 30, 2010 -- Canadian Web Hosting ( ... announced an increase of benefits for their popular affiliate program. The immediate increase from ...
... Boston University School of Medicine found that women with serum ... risk of developing gout than men. This study, the ... gout risk in women, also evaluated purported risk factors for ... and diuretic use to be among leading contributors for women. ...
... What makes some viral infections fatal and others much ... that a part of the variability can be attributed ... Professor Michael Katze, presenting at the Society for General ... modelling could be a powerful tool to allow treatments ...
Cached Medicine News:Health News:Proper Home Dcor May Assist in Alleviating Back Pain 2Health News:Proper Home Dcor May Assist in Alleviating Back Pain 3Health News:Caribbean Cruise Announced by Tahitian Noni International for 2011 2Health News:CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness 2Health News:CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness 3Health News:Canadian Web Hosting Increases Affiliate Incentive 2Health News:Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women 2Health News:Personalizing medicine to prevent pandemics 2
(Date:1/15/2014)... the leading health care supply chain expertise, analytics and ... national contracts that expand its portfolio to provide hospital ... These include manufacturer product and service agreements, as well ... IT consulting support. New Novation agreements ...
(Date:1/15/2014)... OAKS, Calif. , Jan. 15, 2014 ... Amgen (NASDAQ: AMGN ) announced today ... jointly discover and validate new therapeutic targets and ... a chronic disorder that affects millions worldwide. The ...
(Date:1/15/2014)...  Humberto C. Antunes,  Galderma  worldwide CEO, will receive a ... of Drugs in Dermatology (JDD) at the upcoming ... is January 17-20, 2014, at the Omni Orlando Resort at ChampionsGate ... The ODAC is a distinguished event that delivers a ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... neurophysiological monitoring system has been designed ... the needs of the ever changing ... collection and analyzing data from multiple ... EMG, EEG and multiple patients at ...
... Inc. is the largest independently ... to ophthalmic surgical instrumentation. Katena ... 7,000 customers in the United ... network of distributors, to customers ...
... Studies have proven that the management of diabetes ... glucose levels is the most effective way to ... care aimed at maintaining or improving a diabetes ... and costly. , ,These have been the ...
... is intended for detecting trends and tracking ... 18 and older) and children/adolescents (aged 7 ... the use of the G2 Biographer with ... to supplement, not replace, conventional blood glucose ...
Medicine Products: