Navigation Links
Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients
Date:12/4/2008

Side effects similar to those seen with standard dose of daunorubicin, study shows

THURSDAY, Dec. 4 (HealthDay News) -- A high dose of the chemotherapy drug daunorubicin prolonged survival for patients with previously untreated acute myeloid leukemia (AML), preliminary results of a study sponsored by the U.S. National Cancer Institute (NCI) show.

AML is a cancer of the blood and bone marrow. This study included 633 patients, aged 16 to 60, who were randomly assigned to receive either high-dose or standard-dose daunorubicin.

Both doses were given in combination with another chemotherapy drug called ara-C (cytarabine). The patients in the high-dose group received 90 milligrams of daunorubicin per square meter of body surface area (90 mg/m2) on each of the first three days of treatment. The standard dose is 45 mg/m2.

Patients in the high-dose group had a median overall survival of 23.7 months, compared to 15.1 months for those in the standard-dose group. Both groups had similar frequencies of serious treatment-related toxicity, according to the study, conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG).

"The findings of this large clinical trial are important, because they will likely change practice and improve the outcome for many patients with AML," Dr. Martin Tallman, chairman of the ECOG leukemia committee and a professor of medicine at Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center in Chicago, said in an NCI news release.

Daunorubicin is already FDA-approved for treatment of AML, which means that patients with the disease may gain immediate benefit from the findings.

More than 13,000 people in the United States will be diagnosed with AML in 2008. Most cases occur in adults, and about half occur in those younger than 60. Only about one-third of AML patients survive the disease, and the odds of survival decrease with age.

More information

The American Cancer Society has more about acute myeloid leukemia.



-- Robert Preidt



SOURCE: U.S. National Cancer Institute, news release, Nov. 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Higher rates of mental illness among the homeless in Western countries
2. Risk of death may be higher with drug commonly used during cardiac surgery
3. Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
4. Avandias Heart Risk Higher Than Others in Its Class
5. TargetScan Evaluation is Shown to Deliver Potentially Higher Cancer Detection Rate and More Accurate Assessment of Grade
6. Physicians Anticipate Higher Prescribing Based on JUPITER Study
7. Non-AIDS Cancer Risk Higher for Those With HIV
8. Death Rates Higher for Minority Children Awaiting Heart Transplant
9. Mesa Labs Reports Higher Quarterly Sales and Earnings
10. Rural women are at higher risk of blood pressure disorders during pregnancy
11. Liver transplant recipients have higher cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients
(Date:4/28/2017)... ... April 28, 2017 , ... ... . These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on ... or disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, ...
(Date:4/28/2017)... ... , ... The Texas Cord Blood Bank (TCBB), a program of nonprofit biomedical ... Women’s Hospital at Renaissance in Edinburg for their outstanding efforts in collecting umbilical cord ... donate. , “Women’s Hospital at Renaissance has been a collection partner for the ...
(Date:4/28/2017)... ... April 28, 2017 , ... Bill Howe started his sewer ... coastal communities. After Tina Howe joined the team, the Bill Howe brand was born ... at affordable rates, and giving back to the San Diego community in which they ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... assisting the Brooke Grove Foundation implement a Microsoft Dynamics GP solution that integrates ... leading ERP expert that specializes in long-term care, Brooke Grove now has the ...
(Date:4/28/2017)... ... 28, 2017 , ... Semrock’s highly popular SearchLight Spectra Viewer ... resource for fluorescence microscopists and optical system designers, enabling The Right Solution, Right ... the globe, SearchLight has become a tremendously popular tool for the fluorescence imaging ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... WOONSOCKET, R.I. , April 20, 2017 /PRNewswire/ ... (NYSE: CVS), today unveiled a new store design ... new assortment of healthier food, health-focused products and ... the store to help customers discover new offerings. ... represent the next evolution of the customer experience ...
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
(Date:4/19/2017)... YORK , April 19, 2017 Cardiology devices ... the projected period The Cardiology Devices segment is ... than US$ 15 Mn in 2018 over 2017. By the ... a market valuation close to US$ 700 Mn, expanding at ... Devices segment dominated the Asia Pacific ...
Breaking Medicine Technology: