Navigation Links
Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients
Date:12/4/2008

Side effects similar to those seen with standard dose of daunorubicin, study shows

THURSDAY, Dec. 4 (HealthDay News) -- A high dose of the chemotherapy drug daunorubicin prolonged survival for patients with previously untreated acute myeloid leukemia (AML), preliminary results of a study sponsored by the U.S. National Cancer Institute (NCI) show.

AML is a cancer of the blood and bone marrow. This study included 633 patients, aged 16 to 60, who were randomly assigned to receive either high-dose or standard-dose daunorubicin.

Both doses were given in combination with another chemotherapy drug called ara-C (cytarabine). The patients in the high-dose group received 90 milligrams of daunorubicin per square meter of body surface area (90 mg/m2) on each of the first three days of treatment. The standard dose is 45 mg/m2.

Patients in the high-dose group had a median overall survival of 23.7 months, compared to 15.1 months for those in the standard-dose group. Both groups had similar frequencies of serious treatment-related toxicity, according to the study, conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG).

"The findings of this large clinical trial are important, because they will likely change practice and improve the outcome for many patients with AML," Dr. Martin Tallman, chairman of the ECOG leukemia committee and a professor of medicine at Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center in Chicago, said in an NCI news release.

Daunorubicin is already FDA-approved for treatment of AML, which means that patients with the disease may gain immediate benefit from the findings.

More than 13,000 people in the United States will be diagnosed with AML in 2008. Most cases occur in adults, and about half occur in those younger than 60. Only about one-third of AML patients survive the disease, and the odds of survival decrease with age.

More information

The American Cancer Society has more about acute myeloid leukemia.



-- Robert Preidt



SOURCE: U.S. National Cancer Institute, news release, Nov. 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Higher rates of mental illness among the homeless in Western countries
2. Risk of death may be higher with drug commonly used during cardiac surgery
3. Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
4. Avandias Heart Risk Higher Than Others in Its Class
5. TargetScan Evaluation is Shown to Deliver Potentially Higher Cancer Detection Rate and More Accurate Assessment of Grade
6. Physicians Anticipate Higher Prescribing Based on JUPITER Study
7. Non-AIDS Cancer Risk Higher for Those With HIV
8. Death Rates Higher for Minority Children Awaiting Heart Transplant
9. Mesa Labs Reports Higher Quarterly Sales and Earnings
10. Rural women are at higher risk of blood pressure disorders during pregnancy
11. Liver transplant recipients have higher cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset ... of specialty vendors and unique items from across the nation, this holiday-themed event will ... services offered by the VNA. The boutique will be open Saturday, November 4 ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: