Navigation Links
High zinc status in lung cells slows growth and induces DNA damage-induced gene expression
Date:2/25/2008

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of growth arrest and DNA damage-induced gene (Gadd45) mRNA and protein expression, and blockage of G2/M cell cycle progression. The research, published in the March 08 issue of the Experimental Biology and Medicine, demonstrated that the essential nutrient zinc, at elevated physiologic level, is capable of inducing stress responsive genes in the NHBE cells. NHBE cells function as a protective airway barrier and are representative of the cell population during lung tissue transformation and are considered to be progenitor cells for human bronchial cancer.

Gadd45 is ubiquitously expressed in response to genotoxic agents, and is involved in many biological processes related to the maintenance of genomic stability and apoptosis. Over expression of Gadd45 was found to induce G2/M cell cycle arrest. The importance of Gadd45 in G2/M regulation was further supported by findings of the inability of cells from Gadd45 knockout mice to arrest at the G2/M phase after exposure to UV radiation. In addition, a functional association between stress-activated mitogen-activated protein kinase p38 pathway and Gadd45 in response to environmental stresses has been established in past studies. Moreover, the dependence of Gadd45 induction for the normal function of the tumor suppressor gene p53, which plays an important role in the maintenance of genomic fidelity by controlling cell cycle checkpoints and apoptotic processes following cell exposure to genotoxic stress, is well established. Furthermore, in response to DNA damage, Gadd45 was found to contribute to the stability of p53.

The research team, led by David K. Y. Lei, a professor of Nutrition, and Rita S. M. Shih, a recent
'/>"/>

Contact: David K.Y. Lei
dlei@mail.umd.edu
301-405-2143
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. TransUnion Addresses Ohio Attorney Generals Concerns Surrounding Non-Profit Tax-Exempt Status
2. Timely Cancer Diagnosis Linked to Insurance Status
3. Major study links insurance status to advanced stage in multiple cancers
4. Landmark Articles Published by QualityMetric Scientists Report Improvements in Short Form Health Status Measures and Establish Criteria for Future Development
5. Ocera Therapeutics Receives Orphan Drug Status for AST-120 for Pouchitis
6. Insurance status linked to cancer outcomes
7. Alzheimers Foundation of America Awards Excellence in Dementia Care Status to First Adult Day Center, More Long-Term Care Settings
8. Isis Announces ISIS 333611 Granted Orphan Drug Status for Treatment of ALS
9. TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA
10. Unstable housing status increases the risk of HIV transmission
11. Global view shows link between endometrial cancer and vitamin D status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... August 01, 2014 Stryker hip ... of the 2012 Rejuvenate and ABG II Modular-Neck ... New Jersey’s Bergen County Superior Court, Bernstein Liebhard ... proceeding, the Court has issued a Final ... and all hard copy and electronic materials produced ...
(Date:8/1/2014)... August 01, 2014 Summer is here, and ... active during the summer, and they can be a pain ... ready to help all their customers get rid of ticks ... and 6,000 eggs in the summer, which is why they ... in tall grass and woodland areas and carry a number ...
(Date:8/1/2014)... Washington, DC (PRWEB) August 01, 2014 ... Mike Thompson (D-CA), Gregg Harper (R-MS), and Peter ... H.R. 5380, the Medicare Telehealth Parity Act of ... "We fully support this effort to improve healthcare ... Linkous, chief executive officer of ATA. "These cost-saving ...
(Date:8/1/2014)... The "Antimicrobial Coatings Market by Type (Silver, ... Dioxide, and Zinc Omadine), Application (Indoor air/HVAC, Medical, ... Textiles, and others), & Geography (North America, Europe, ... to 2018" analyzes the Antimicrobial Coatings Market with ... the diverse geographical regions. , Browse 49 market ...
(Date:8/1/2014)... The North America Endpoint Security Market report defines ... America with analysis and forecast of revenue. This market ... 2014 to $4.77 billion by 2019, at a CAGR ... the TOC of the North America Endpoint Security Market ... provided. It also provides a glimpse of the segmentation ...
Breaking Medicine News(10 mins):Health News:Stryker Hip Lawsuit News: New Order Issued in New Jersey Stryker Hip Recall Litigation, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit News: New Order Issued in New Jersey Stryker Hip Recall Litigation, Bernstein Liebhard LLP Reports 3Health News:Tis the Season for Tick Prevention 2Health News:ATA Applauds Bill on Medicare Telemedicine Improvements 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 3Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 4Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 2Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 3Health News:North America End-Point Security Market is Expected to Reach $4 billion in 2019 - New Report by MicroMarket Monitor 4
... , ARLINGTON, Va., Oct. 8 The U.S. Centers for ... TriData division, which specializes in public safety research and ... prevention practices in 10 nations. , The study ... reductions in fire deaths and injuries in these nations. ...
... Greater Surface Disinfection to Combat Bad Hygiene , ARLINGTON, Va., ... standing in the lunch line? Or sneeze loudly into the ... (96 percent) have seen you do things like this -- and ... , Even with heightened concerns during this year,s flu season, ...
... ... device, a rapid phase transition gel used in the treatment of Kidney Stones. ... Woburn, Massachusetts (PRWEB) ... alliance with Boston Scientific Corporation (NYSE: BSX) regarding Pluromed,s BackStop™ product, a device used ...
... ... media, cell separation products and ancillary reagents for life science research, is pleased to ... ... 8, 2009 -- STEMCELL Technologies Inc. (STEMCELL), a leader in specialty cell culture media, ...
... ... announces the release of their Mediterranean Diet Resveratrol Formula. , ... Plainview, NY (PRWEB) October ... dietary supplements, announces the release of their Mediterranean Diet Resveratrol Formula., , ,Purity,s ...
... , ... week, the Cheney Research Web site ( www.cheneyresearch.com ) is a multimedia medical Web ... cutting-edge medical concepts and therapies developed at the Cheney Clinic and conveyed in part ... ...
Cached Medicine News:Health News:International Study Finds New Best Practices to Reduce Fire Casualties 2Health News:Gross Germ-Spreading Behaviors Remain the Norm, Despite Flu Season Concerns 2Health News:Gross Germ-Spreading Behaviors Remain the Norm, Despite Flu Season Concerns 3Health News:Pluromed, Inc. Signs Agreement with Boston Scientific 2Health News:Pluromed, Inc. Signs Agreement with Boston Scientific 3Health News:STEMCELL Technologies Inc. Announces Direct Distribution to Spain 2Health News:Purity Products Releases Their Brand New Mediterranean Diet Resveratrol Formula 2Health News:Chronic Fatigue Syndrome and Stem Cell Therapy - Latest Research Available at CheneyResearch.com 2Health News:Chronic Fatigue Syndrome and Stem Cell Therapy - Latest Research Available at CheneyResearch.com 3
(Date:8/1/2014)... , Aug. 1, 2014 RoundTable ... focused exclusively on the healthcare industry, announced today ... The Lubrizol Corporation ("Lubrizol"). Lubrizol, a Berkshire Hathaway ... and supplies technologies to customers in the global ... transaction were not disclosed. Vesta is ...
(Date:8/1/2014)... Minn. , Aug. 1, 2014 ... medical technologies company, announced today that it has ... held manufacturer of cardiorespiratory diagnostic products based in ... MediSoft has served the European cardiorespiratory diagnostics market ... 2013 revenues of approximately €4.7 million ($6.3 million) ...
(Date:8/1/2014)... , Aug. 1, 2014 Dyadic International, Inc. ... and proprietary technologies are used to develop, manufacture and ... chemical, biopharmaceutical and industrial enzyme industries, announced today that ... quarter ended June 30, 2014 after market close on ... call that day at 5:00 p.m. Eastern Time to ...
Breaking Medicine Technology:RoundTable Healthcare Partners Announces Sale of Vesta Funding, Inc. to The Lubrizol Corporation 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3
... The model 55S Rocking Shaker ... gels and blotted membranes. The very ... adjustable degree of tilt provide a ... washes over gels and blotted membranes ...
... The model 55S Rocking Shaker ... gels and blotted membranes. The very ... adjustable degree of tilt provide a ... washes over gels and blotted membranes ...
Multi-Tier Shaker...
... The Thermo Labsystems Wellmix is a ... and time settings. The shaking speed is ... shaking frequency, high speed and a small ... assays. The shaking time is quick and ...
Medicine Products: