Navigation Links
High weight associated with risk of colorectal tumors without microsatellite instability
Date:3/5/2010

The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability (MSI), a common condition in most colorectal cancers, according to a new study published online March 8 in the Journal of the National Cancer Institute.

This study was undertaken because little is know about the associations between body mass index and adult weight gain and the risk of colorectal cancer overall and by tumor MSI status.

Peter T. Campbell, Ph.D., of the Epidemiology Research Program at the American Cancer Society in Atlanta, and colleagues performed a casecontrol study of subjects with incident colorectal cancer and their unaffected sex-matched siblings to evaluate associations between being overweight or obese (defined according to body mass index) and adult weight change and colorectal cancer risk. They evaluated the associations with cancer risk, overall and by tumor MSI status, assessed at up to 10 markers for microsatellite stability. Patients that are diagnosed with tumors that are microsatellite-stable or MSI-low have lower 5-year survival rates than patients with tumors that are MSI-high.

Recent body mass index (people over 30 kg/m2 or more, the cut off for obesity) was positively associated with overall risk of colorectal cancer for men and women combined. It was also associated with risk of MS-stable and MSI-low colorectal tumors, but not with the risk of MSI-high tumors.

"Our data also suggest that the associations between [body mass index] and adult weight gain and the risk of colorectal cancer differ between MS-stable and MSI-high tumors suggesting differing underlying etiologies for colorectal cancer according to tumor MSI," the authors write.

In an accompanying editorial, Shuji Ogino, M.D., Ph.D, of the Department of Medical Oncology at the Dana-Farber Cancer Institute, and Harvard Medical School in Boston, and Meir Stampfer, M.D., of the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, in Boston, said that this type of approach (the convergence of traditional epidemiology and traditional pathology research) will continue to provide useful insights on carcinogenic processes, specifically our understanding of how particular exposures influence carcinogenesis.

The editorialists write: "These molecular pathological epidemiology data imply that molecular markers (such as MSI) can be used to classify colorectal cancers into distinct subtypes, which have implications for both etiology and prevention."


'/>"/>

Contact: Caroline McNeil
caroline.mcneil@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Early Weight Loss in Women Linked to Dementia
2. New research explores newborn in-hospital weight loss
3. Weight-Loss Surgeries Extend Lives
4. School-based overweight prevention program may cut risk of eating disorders among girls
5. Overweight toddlers and those not in day care at risk for iron deficiency
6. Weight Watchers Declares Quarterly Dividend
7. Eat Seafood, See Weight Loss: Recent Study Finds Another Reason to Eat Seafood for a Fit Lifestyle
8. Weight Gain May Spell Trouble for Heart Failure Patients
9. New Research From America On the Move Foundation Indicates American Weight Loss Efforts Stalling
10. Weight loss game looking for NEAT-o results
11. Aerobic, Weight Training Combo Best Against Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... 10, 2017   West Pharmaceutical Services, Inc. ... injectable drug administration, today shared the results of a ... improving the intradermal administration of polio vaccines. The study ... in May 2017 by Dr. Ondrej Mach , ... Health Organization (WHO), and recently published in the journal ...
Breaking Medicine Technology: