Navigation Links
High-tech 'whole body' scan could improve treatment of bone marrow cancer
Date:1/28/2014

The new type of magnetic resonance imaging (MRI) scan could improve care for a type of cancer called myeloma and reduce reliance on bone marrow biopsies, which can be painful for patients and often fail to show doctors how far the disease has spread.

The research is published today (Tuesday) in the journal Radiology and was carried out by researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust.

It received funding from Cancer Research UK and the National Institute for Health Research Clinical Research Facility in Imaging, with additional funding from the EPSRC.

The new whole-body, diffusion-weighted MRI scans showed the spread of cancer throughout the bone marrow of patients with myeloma - one of the most common forms of blood cancer - more accurately than standard tests. The scans also showed whether the patients were responding to cancer treatments.

In the study 26 patients had whole-body, diffusion-weighted MRI scans before and after treatment. In 86% of cases, experienced doctors trained in imaging were able to correctly identify whether patients responded to treatment. The doctors also correctly identified those patients who weren't responding to treatment 80% of the time.

Using the scanning technique, doctors could pinpoint exactly where the cancer was in the bones, with the results available immediately. Conventional tests include bone marrow biopsies and blood tests but neither shows accurately where the cancer is present in the bones.

The researchers also assessed the visible changes on the MRI scans, using a measurement called the Apparent Diffusion Coefficient (ADC), which records how restricted water movement is within tissues. Changes in this measurement correctly identified treatment response for 24 of 25 myeloma patients.

The new scan was able to visualise cancer in almost all bones in the body, with only the skull remaining difficult to image partly because of the frequency of metal dental implants and fillings. The researchers also found the new methods were suitable for more patients than conventional tests; for example, seven patients had bone marrow biopsies but their samples were found to be inadequate for analysis. Performing another biopsy could be traumatic and painful, and may not provide any new information.

Professor Nandita deSouza, Professor of Translational Imaging at The Institute of Cancer Research and Honorary Consultant at The Royal Marsden, said: "This is the first time we've been able to obtain information from all the bones in the entire body for myeloma in one scan without having to rely on individual bone X-rays. It enables us to measure the involvement of individual bones and follow their response to treatment.

"The results can be visualised immediately; we can look on the screen and see straight away where the cancer is and measure how severe it is. The scan is better than blood tests, which don't tell us in which bones the cancer is located. It also reduces the need for uncomfortable biopsies, which don't reveal the extent or severity of the disease."

Dr Faith Davies, member of the Myeloma Targeted Treatment Team at The Institute of Cancer Research and Honorary Consultant at The Royal Marsden, said: "Myeloma can affect bones anywhere in the body, which is why this study is so important. We've shown that whole body MRI scans can accurately monitor how myeloma patients are responding to treatment, allowing doctors to make more informed decisions. With this new scan, if a treatment isn't working the patient can be moved onto new therapies that might be more effective much more quickly.

"This is a small study, so our next step will be to try out the technology in more patients and refine it. In the future we hope this new tool will help doctors extend the life of more myeloma patients. "

Julia Frater, Cancer Research UK's Senior Cancer Information Nurse, said: "Finding kinder ways to monitor how patients respond to treatment is really important, particularly in the case of myeloma where taking bone marrow samples can be painful. This research demonstrates how an advanced imaging technique could provide a whole-skeleton 'snapshot' to track the response of tumours in individual bones. Finding ways to make treatments gentler and improve the experience for patients is an important focus for Cancer Research UK and the research we fund."


'/>"/>
Contact: Graham Shaw
Graham.Shaw@icr.ac.uk
44-020-715-35380
Institute of Cancer Research
Source:Eurekalert

Related medicine news :

1. Botanisol™, A Glendale-Based High-Tech Firm Applies for $250,000 Grant to Create High-Paying Research Associate Jobs and Complete Pre-Clinical Development
2. Infection Prevention, High-tech Transport Boost St. Louis Children’s to #6 in the Nation
3. Given Brand Sports Now Offers a Full Line of High-Tech Running Watches and Gear Helping Athletes Set Their Race P.R.'s
4. Ambiance Expands Romantic Technology Leadership with New High-Tech Toy
5. High-tech cerebral palsy research at SDSU
6. As Doctors Go High-Tech, Staff Injuries May Rise
7. High-Tech CT Scan May Get People With Chest Pain Home Faster
8. Kudos for 3 NJIT Enterprise Development Center high-tech companies
9. Wholesale Microfiber Detailing Towels Now Available from Microfiber Tech
10. No Medical Exam Life Insurance Can Provide Coverage Before Christmas for the Whole Family
11. SeeTips.com Announces The Best Online Store to Buy Wholesale Dresses and Electronics From China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, ... Murthy explains how he was inspired to practice medicine at an early age by ... about more than making diagnoses and prescribing medicine,” he states. “It is about building ...
(Date:12/2/2016)... York, NY (PRWEB) , ... December 02, 2016 , ... ... high school and while 84 percent of parents report speaking with their child about ... pornography and sexually transmitted diseases. , Mediaplanet is proud to announce the launch of ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical Systems, Inc. ... the first company to offer robotic imaging to veterinary medicine is sponsoring the ... 941 for the American Association of Equine Practitioners 62nd Annual Convention from December ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... "Pro3rd Accents ... FCPX editors to create versatile lower third titles with just a few clicks of ... Accents Volume 2 includes 30 lower third animations. Choose from various styles with accented ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Scientist & Author of Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein ... Kleyne Hour Power of Water, Global Climate Change and Your Health radio program ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
(Date:12/2/2016)... 1, 2016 The concept of rare diseases and ... to this sector has been taking shape in ... political aspects and initiatives related to orphan medicinal products have ... level of member states individually. Many member states in the ... space of orphan medicinal products, the result of which took ...
(Date:12/2/2016)... Allergan plc (NYSE: AGN ), a ... previously announced Accelerated Share Repurchase (ASR) Program. Logo - ... ... previously announced, the Company entered into a variable tenor ASR ... repurchase $10 billion of its ordinary shares. Approximately 40.5 million ...
Breaking Medicine Technology: