Navigation Links
High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
Date:10/6/2009

PHILADELPHIA Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow.

Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. Results of this proof-of-concept study are published in Cancer Research, a journal of the American Association for Cancer Research.

"This promises to significantly enhance the detection for residual disease in leukemia and other cancers," said lead scientist Richard S. Larson, M.D., Ph.D., vice president for translation research at the University of New Mexico Health Science Center. "Coupling nanotechnology can be employed in common techniques to enhance its utility."

These findings are a result of a collaborative research effort between Senior Scientific, LLC, and the University of New Mexico. The study was funded by a small business innovation grant awarded by the National Cancer Institute.

Previous studies have indicated that the magnetic needle can collect approximately 80 percent of leukemia cells in a bone marrow sample in a matter of minutes, according to Edward R. Flynn, Ph.D., president and CEO of Senior Scientific, LLC.

The scientists developed this magnetic marrow biopsy needle in an effort to target tumor cells with nanoparticles and then preferentially extract the tumor cells with a magnetic needle. They used anti-CD34 antibody loaded magnetic nanoparticles to detect CD34+ cells as an indicator of leukemia. To quantify the cells recovered, they coupled this nanoparticle-mediated fishing for leukemic cells with SQUID.

SQUID enhanced the sensitivity of measuring minimal residual disease over standard pathology methods for patients undergoing chemotherapy.

"This result will determine more precisely the effect of the chemotherapy and will help to ascertain proper dosage or termination of treatment for patients," said Flynn.

Furthermore, Larson said that SQUID will work well with current technologies to improve the detection of leukemia cells in the bone marrow. Chi Van Dang, M.D., Ph.D., professor of medicine, cell biology, oncology and pathology, and vice dean for research at the Johns Hopkins University School of Medicine, believes this approach is quite different from the current standard. He suggested that the sensitivity compared to polymerase chain reaction still needs to be determined.

"In the case of leukemias without clear genetic markers, the magnetic needle could be useful," said Dang, who was not associated with this study, but is an editorial board member for Cancer Research. "It is possible that this technology could be used to detect cancer stem cells in general, if the proper antibodies with appropriate specificity are available."

Senior Scientific, LLC is currently participating in follow-up studies to increase the efficiency of the magnetic needle further through advanced magnet configurations and theoretical calculations.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Related medicine news :

1. Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease
2. Save a Life: Join the Kiel Mortgage Marrow-thon on September 23
3. Help Save a Life - Bone Marrow Donor Registry Drive Sept. 2 at the Karmanos Cancer Center
4. ThermoGenesis Announces Launch of Res-Q System; New Device Expands Companys Presence in Bone Marrow Sector
5. Cerebral Palsy Improves After Bone Marrow Stem Cell Procedure
6. Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
7. Trimming the fat boosts blood recovery after marrow transplant
8. National Marrowthon Campaign Aims to Bring Nearly 50,000 to the Be The Match Registry(SM) in Two Weeks
9. Weber Shandwick Chosen By National Marrow Donor Program(R) To Head Awareness Campaign
10. Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors
11. Bone Marrow Registry to Launch Groundbreaking Fundraising Technology to Overcome Madoff Crisis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
Breaking Medicine Technology: