Navigation Links
High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
Date:10/6/2009

PHILADELPHIA Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow.

Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. Results of this proof-of-concept study are published in Cancer Research, a journal of the American Association for Cancer Research.

"This promises to significantly enhance the detection for residual disease in leukemia and other cancers," said lead scientist Richard S. Larson, M.D., Ph.D., vice president for translation research at the University of New Mexico Health Science Center. "Coupling nanotechnology can be employed in common techniques to enhance its utility."

These findings are a result of a collaborative research effort between Senior Scientific, LLC, and the University of New Mexico. The study was funded by a small business innovation grant awarded by the National Cancer Institute.

Previous studies have indicated that the magnetic needle can collect approximately 80 percent of leukemia cells in a bone marrow sample in a matter of minutes, according to Edward R. Flynn, Ph.D., president and CEO of Senior Scientific, LLC.

The scientists developed this magnetic marrow biopsy needle in an effort to target tumor cells with nanoparticles and then preferentially extract the tumor cells with a magnetic needle. They used anti-CD34 antibody loaded magnetic nanoparticles to detect CD34+ cells as an indicator of leukemia. To quantify the cells recovered, they coupled this nanoparticle-mediated fishing for leukemic cells with SQUID.

SQUID enhanced the sensitivity of measuring minimal residual disease over standard pathology methods for patients undergoing chemotherapy.

"This result will determine more precisely the effect of the chemotherapy and will help to ascertain proper dosage or termination of treatment for patients," said Flynn.

Furthermore, Larson said that SQUID will work well with current technologies to improve the detection of leukemia cells in the bone marrow. Chi Van Dang, M.D., Ph.D., professor of medicine, cell biology, oncology and pathology, and vice dean for research at the Johns Hopkins University School of Medicine, believes this approach is quite different from the current standard. He suggested that the sensitivity compared to polymerase chain reaction still needs to be determined.

"In the case of leukemias without clear genetic markers, the magnetic needle could be useful," said Dang, who was not associated with this study, but is an editorial board member for Cancer Research. "It is possible that this technology could be used to detect cancer stem cells in general, if the proper antibodies with appropriate specificity are available."

Senior Scientific, LLC is currently participating in follow-up studies to increase the efficiency of the magnetic needle further through advanced magnet configurations and theoretical calculations.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Related medicine news :

1. Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease
2. Save a Life: Join the Kiel Mortgage Marrow-thon on September 23
3. Help Save a Life - Bone Marrow Donor Registry Drive Sept. 2 at the Karmanos Cancer Center
4. ThermoGenesis Announces Launch of Res-Q System; New Device Expands Companys Presence in Bone Marrow Sector
5. Cerebral Palsy Improves After Bone Marrow Stem Cell Procedure
6. Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
7. Trimming the fat boosts blood recovery after marrow transplant
8. National Marrowthon Campaign Aims to Bring Nearly 50,000 to the Be The Match Registry(SM) in Two Weeks
9. Weber Shandwick Chosen By National Marrow Donor Program(R) To Head Awareness Campaign
10. Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors
11. Bone Marrow Registry to Launch Groundbreaking Fundraising Technology to Overcome Madoff Crisis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
(Date:3/22/2017)... NJ (PRWEB) , ... March 22, 2017 , ... ... Group, the nation’s leading digital and print media enterprise focused on cancer patients, ... video content, has released a special 12-part educational video series, “No Ifs, Ands, ...
(Date:3/22/2017)... ... March 22, 2017 , ... An intensive search of the ... HIV, reports Leslie Norins, MD, PhD. He says investigating this possibility, is ... Zika virus and in new infections with HIV. , His findings appear ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Last year, ... to a US Department of Agriculture report. While excess dairy can be caused ... a role. Lactose sensitivity is the inability to properly digest lactose, a sugar found ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Vanderbeck Agency, a Long Island ... County region, is embarking on a combined charity effort with the Great Neck Breast ... last 25 years, the Great Neck Breast Cancer Coalition has worked to support breast ...
(Date:3/22/2017)... ... March 22, 2017 , ... The ... related services to families and business owners in the greater Nassau County area, ... & Lymphoma Society. , Every 3 minutes, someone in America is diagnosed with ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... March 22, 2017  CANTEL MEDICAL CORP. (NYSE: ... President and CEO, will be presenting at the 16 th ... Grand Central Hotel in New York . ... at 3:00 p.m. ET. In addition, management will be available ... A live audio webcast will be available via the investor ...
(Date:3/22/2017)... 2017  Ablation is the minimally invasive therapeutic ... of purposes, from cancerous or diseased tissue removal, ... in atrial fibrillation and others. The growing adoption ... to innovate and improvise existing ablation technologies for ... global market is expected to grow at high ...
(Date:3/22/2017)... LINCOLN, Mass. , March 22, 2017 /PRNewswire/ ... applying mechanistic modeling to drug research and development, ... QSP Day 2017.  QSP Day 2017 is a ... with the quantitative systems pharmacology (QSP) community. The ... mathematical modeling is de-risking and accelerating drug research ...
Breaking Medicine Technology: