Navigation Links
High-salt diet and ulcer bug combine to increase risk of cancer
Date:4/18/2013

Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer. Now Timothy L. Cover and colleagues of Vanderbilt University show that high dietary salt combined with infection by the ulcer-causing bacterium Helicobacter pylori greatly increases the risk of cancer. The study was published ahead of print in the journal Infection and Immunity.

In the study, the researchers infected Mongolian gerbils with H. pylori. One set of gerbils received a regular diet; the other, a high salt diet. At the end of the experiment the researchers analyzed the animals' stomach tissues. Every animal on the high salt diet developed cancer, compared with just 58 percent of those on the regular diet.

It appears development of gastric cancer required the presence of a particular bacterial oncoprotein, known as CagA, which is produced by H. pylori. Gastric cancer did not develop in animals on the high salt diet that were infected with a mutant H. pylori which did not produce CagA. In earlier studies, Cover and others had shown that culturing H. pylori in a high salt environment boosts production of CagA. "This was one of the driving forces that led us to undertake the current studies," says Cover.

The investigators note that while no studies, to their knowledge, have examined relationships among a high salt diet, and infection with H. pylori expressing cagA, "in several parts of the world that have high rates of gastric cancer, there is a high prevalence of cagA+ strains and a large proportion of the population consumes a high-salt diet."

The investigators also detected significantly higher levels of gastric inflammation in H. pylori-infected gerbils on a high salt diet than in those on a regular diet, a finding which Cover says is relevant to many types of cancer. They also showed that transcription of various inflammatory cytokines, such as interleukin 1-beta, are elevated in the former as compared to the latter, suggesting that "these factors may contribute to the increased inflammation and increased gastric risk that accompany a high salt diet," says Cover.

At least 50 percent of humans are infected with H. pylori, at least 90 percent of them without symptoms.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
2. Zion Health Announces Release of New Line of Home Remedies: Kanwa Whole Body Detox teas for Stomach Pain, Ulcers, and Skin Allergies Now available at Bee Health E in Doug
3. Pressure Ulcer Treatment and Prevention Cushions Designed by EHOB Now Offered by Rehabmart.com
4. Stroke drug kills bacteria that cause ulcers and tuberculosis
5. Foot Ulcers Tied to Increased Death Risk for People With Diabetes
6. New Pill Appears Effective, Safe for Ulcerative Colitis: Study
7. NYU School of Medicine announces new clinical trial for ulcerative colitis
8. Spray-on Skin May Someday Heal Stubborn Leg Ulcers
9. Gastric feeding tubes may raise pressure ulcer risk
10. Spencer Institute Lifestyle Fitness Coach Certification Combines Life Coaching and Fitness Coaching in One Powerful Online Training
11. Asbestos exposure, asbestosis, and smoking combined greatly increase lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... GeBBS Healthcare ... Assurance, at HCCA’s 21st annual Compliance Institute on March 26-28 in National Harbor, ... for all medical chart types with a comprehensive set of features including built-in ...
(Date:3/23/2017)... ... ... Woman Be Ye Healed-Passing On A Legacy”: a call to heal the wounded Church. ... author, Desiree M Webb, a registered nurse, minister of music, speaker, songwriter, recording artist, ... husband, Paul, for over twenty-nine years. Desiree enjoys writing, beach trips, ministering in ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... the existence of God. “A Respectful Response To Atheist Manifesto” is the creation ... married to his wife, Nancy, for sixty years. He holds graduate degrees from ...
(Date:3/23/2017)... ... March 23, 2017 , ... Vortex Biosciences, provider ... protein expression in circulating tumor cells using microfluidic western blotting” in Nature Communications ... Vortex technology to capture CTCs and a microfluidic single-CTC resolution Western ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had won the ‘Clinical ... at the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... NORTH CHICAGO, Ill. , March 23, 2017 /PRNewswire/ ... actress, dancer and Emmy Award-winning choreographer Julianne Hough ... a campaign called "Get in the Know about ME ... AbbVie, is dedicated to inspiring women to learn about ... in 10 women, 1 and to address their ...
(Date:3/23/2017)... , March 23, 2017 ... presented in Brussels , My ... change bad sun habits into life-saving ones, was ... Association (AIM). Launched in 2016, the "Nudging for ... it easy and desirable for people to change ...
(Date:3/22/2017)... Mar. 22, 2017 Research and Markets has ... Analysis & Trends - Industry Forecast to 2025" report to ... ... a CAGR of around 10.9% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Medicine Technology: