Navigation Links
High-risk prostate cancer associated with significantly lower bone mineral content loss
Date:7/13/2010

Men with prostate cancer lose significantly less bone mineral content (BMC) as they age than men who are free of the disease, according to research in the July issue of BJUI. The findings are important because loss of BMC can play a key role in the development of fragile bones, fractures and osteoporosis.

American researchers studied 519 participants who joined the Baltimore Longitudinal Study at an average age of 56 between 1973 and 1984. The maximum follow-up was 35 years and the median was 22 years. Seventy-six men who took part in the study were later diagnosed with prostate cancer, with just under a quarter (24 per cent) falling into the high-risk category.

When they charted the individual BMCs of the study subjects over an extended period, the researchers could clearly see that the decline was much larger in healthy men than in men later diagnosed with prostate cancer, especially those with high-risk prostate cancer. This occurred despite the fact that the initial baseline readings were very similar for all three groups.

The researchers also adjusted the figures to take account of other factors that affect BMC, such as smoking status, body mass index, dietary calcium and vitamin D. However, this did not change the significant differences between the healthy men and those with prostate cancer.

"There are numerous possible mechanisms to explain the relationship between prostate cancer and BMC" says lead author Dr Stacy Loeb, from Johns Hopkins University, Maryland, USA.

"It is well known that prostate cancer frequently metastasizes (spreads) to bone. Although the biology underlying the association between BMC and this form of cancer requires additional research, our findings suggest that common growth factors might be involved in both bone maintenance and the progression of prostate cancer.

"We believe that this may be why the patients with the highest risk prostate cancer also demonstrated the least loss of BMC as they got older, when compared with patients with non high-risk prostate cancer and no prostate cancer."

The baseline demographics between the three groups of men were similar when it came to their body mass index and smoking history.

The authors believe that this is the first study to explore the relationship between longitudinal BMC measurement and the long-term risk of prostate cancer and, more specifically, life-threatening disease. They point out that the study sample was primarily white (96 per cent) and, due to racial differences in bone density, may not be generally applicable to other ethnic groups.

"We would like to see our theories tested further in larger populations of men at risk of developing life-threatening prostate cancer" concludes Dr Loeb. "If we can better understand the link between prostate cancer and bone, it may help us to find ways of preventing the spread of this disease to bone in the future."


'/>"/>

Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. School-Based Efforts May Help Curb Obesity in High-Risk Kids
2. Surveillance colonoscopy should be targeted to high-risk patients
3. Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy
4. Selecting high-risk patients for heart screening
5. Drug reduces risk of prostate cancer diagnosis in high-risk men
6. New heart valve replacement technologies offer hope for high-risk patients
7. Mammogram Plus MRI Cost-Effective in High-Risk Women
8. Mammogram Plus MRI Seems Cost-Effective in High-Risk Women
9. Combined mammography and breast MRI useful for some high-risk women
10. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
11. How prostate cancer packs a punch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University ... Allen have signed a joint enrollment and degree completion agreement. The agreement, ... and baccalaureate degrees at FHU|Dickson. , The agreement allows students to be ...
(Date:2/5/2016)... Illinois (PRWEB) , ... February 05, 2016 , ... ... and independent PROSHRED franchises from across the country gathered at the La Valencia ... recognize top performers. PROSHRED Chicago was named the year’s most outstanding franchise, ...
(Date:2/5/2016)... ... ... Boar’s Head Brand®, one of the nation’s leading providers of premium delicatessen ... stress out of your party preparation – follow these easy, yet delicious recipes with ... game. , “The key to hosting a successful game-day party is creating a flavorful ...
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, FACS is thrilled ... provide the most effective tattoo removal today, Dr. Bentkover is the only doctor in ... Cynosure, the PicoSure has been approved by the Food and Drug Administration (FDA) as ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Health and ... more relevant to individuals in the event they are experiencing an illness. Migraines are ... Those Americans that are afflicted with migraines would not wish the pain on their ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Henry Schein, Inc. (NASDAQ: HSIC ), the ... to office-based dental, animal health and medical practitioners, announced ... acquire a majority ownership interest in Dental Cremer S.A., ... Brazil . --> ... is the dental distribution business of Cremer S.A. With ...
(Date:2/4/2016)... , Feb. 4, 2016 For hospitals ... or those already participating in the program, the Health ... referred to as the , Mega-Guidance , could have ... guidance is published in September 2016. Essential ... and Service Marketing , summarizes the Mega-Guidance,s key proposed ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... in the United States District Court for the District of ... (the "Class") consisting of all persons or entities who purchased ... (NASDAQ: INSY ) from March 3, 2015 through January ... certain of its officers with violations of the Securities Exchange ...
Breaking Medicine Technology: