Navigation Links
High risk oesophageal cancer gene discovered
Date:1/19/2012

New research from Queen Mary, University of London has uncovered a gene which plays a key role in the development of oesophageal cancer (cancer of the gullet).

The researchers studied families who suffer a rare inherited condition making them highly susceptible to the disease and found that a fault in a single gene was responsible.

Initial studies suggest that the gene could play a role in the more common, non-inherited form of the disease, revealing a new target for treating this aggressive type of cancer.

Oesophageal cancer affects more than 8,000 people each year in the UK and rates are rising. It is more common in the UK than anywhere else in Europe.

Survival rates are poor compared to other types of cancer with only eight per cent of people alive five years after diagnosis. Scientists know little about how oesophageal cancer develops and very few drugs for targeting the disease are currently available.

The new study was led by Professor David Kelsell from Queen Mary, University of London with collaborators from the University of Dundee and the University of Liverpool.

The research concentrated on three families with a hereditary condition called tylosis with oesophageal cancer. This condition affects the skin and mouth and sufferers have a 95 per cent chance of developing oesophageal cancer by the age of 65.

The research revealed that all three families carried a faulty version of a gene called RHBDF2.

Experiments showed that this gene plays an important role in how cells that line the oesophagus, and cells in the skin, respond to injury. When the gene is functioning normally it ensures that cells grow and divide in a controlled fashion to help heal a wound.

However, in tylosis patients' cells, and in cells from oesophageal cancers, the gene malfunctions. This allows cells to divide and grow uncontrollably, causing cancer.

Professor Kelsell explains: "In studying this relatively rare condition, we have made an important dicovery about a cancer that is all too common. Finding a genetic cause for this aggressive cancer, and understanding what that gene is doing, is an enormous step forward.

"By analysing the complex biology which causes a particular type of cancer we begin to understand which treatments might be effective and also which treatments are unlikely to help."


'/>"/>
Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Impaired quality of life: A warning signal after oesophageal cancer surgery
2. Study reveals mechanism of lung-cancer drug resistance
3. Study finds potential key to immune suppression in cancer
4. Comparison of effects of red wine versus white wine on hormones related to breast cancer risk
5. New test offers greater accuracy in early detection of colorectal cancer
6. Drug improves survival of colorectal cancer patients, trial results show
7. 2012 Gastroinstestinal Cancers Symposium reveals new advances aimed at improving treatment, prognosis and detection of GI cancers
8. Cell signaling key to stopping growth and migration of brain cancer cells
9. Study reveals origins of esophageal cancer
10. Drug Duo May Help Fight Aggressive Form of Breast Cancer
11. Childhood cancer research grant awarded to the Research Institute at Nationwide Childrens Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... "ProBrand Flip allows FCPX editors to ... Christina Austin - CEO of Pixel Film Studios. , ProBrand Flip includes 30 flip ... zones. Editors can select from a variety of flip book animations. In Addition, users ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen McLaughlin, ... at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years of ... acupuncturists to help patients realize their family building goals. Acupuncture helps fertility ...
(Date:12/7/2016)... ... 2016 , ... “Walking With God: Inspirational Lessons from My Life's Journey”: ... be aware of God's direction in their lives. “Walking With God: Inspirational Lessons from ... active church leader. , Sanford says, “I enjoy sharing the true stories ...
(Date:12/7/2016)... ... December 07, 2016 , ... The ... Architecture Innovation Summit in Reston, VA on March 21-22, 2017. This premier event ... range of experiences from a cross-section of industries such as financial services, insurance, ...
(Date:12/7/2016)... Warwick, New York (PRWEB) , ... December 07, 2016 , ... ... computer professor at Yale had described him as 'a genius.'" Thus begins "Margaret in ... R. L. Rhyse and published by Wyston Books, Inc. These novels narrate ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016 Diplomat Pharmacy, Inc. (NYSE: ... five subsidiaries—American Homecare Federation, At-Home IV Infusion Professional, BioRx, MedPro Rx, ... specialty infusion services, visit diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat ... "As we continue to build ...
(Date:12/7/2016)... SCIENCE PARK , Israel , ... (TASE: KDST) announced today the signing of a memorandum of understanding ... companies. The synergy between the companies will assist in expediting Kadimastem,s ... worldwide leader in innovative treatment for severe diseases in general and ... , ...
(Date:12/7/2016)...  Based on its recent analysis of ... Sullivan recognizes Nemaura Pharma Limited with the ... Enabling Technology Leadership. Nemaura Pharma,s transdermal drug ... drug delivery technologies, especially in delivering biologics. ... technologies, Memspatch and Micropatch respectively, facilitate minimally ...
Breaking Medicine Technology: