Navigation Links
High pollution linked to poor lung function growth in children in Mexico City
Date:8/15/2007

Children who are chronically exposed to higher levels of air pollution show marked deficiencies in lung growth and function, and not just short-term breathing problems, according to researchers in Mexico.

"Our study revealed significant deficits in lung function growth in children with long-term exposure to air pollutants, wrote Isabelle Romieu, M.D., M.P.H., lead author of the study. "In addition to the important impact of lung health, early lung deficits may increase the risk of developing chronic obstructive lung disease later in life, as well as cardiovascular morbidity and general mortality.

These conclusions are the result of a three-year, multi-site prospective study that measured lung function growth in 3,170 eight-year-old children at 39 schools in Mexico City and analyzed it with respect to the childrens exposure to common urban pollutants: ozone (O3), nitrogen dioxide (NO2), and particulate matter under 10 m (PM10).

Dr. Romieu, of the Instituto Nacional de Salud Publico in Mexico, and eight colleagues reported their findings in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Previous studies have found that short-term exposure to pollutants is associated with acute but reversible deficits in lung function, but the effects of long-term exposure, like that experienced by residents of heavily polluted urban environments, had not been conclusively characterized.

The researchers analyzed forced vital capacity in one second (FVC1); forced expiratory flow, midexpiratory phase (FEF25-75); and forced expiratory volume in one second (FEV1) in the schoolchildren at six month increments over three years to determine the effects of pollutant exposure, which was measured by air monitoring stations within 2 km of the children's schools. They conducted personal exposure assessments on 60 randomly selected children in the study to ensure that the air monitoring station data was an accurate representation of individual exposure.

Although all measurements of lung function increased over time, the researchers found that higher exposure to O3, NO2 and PM10 was significantly associated with growth deficits in FVC and FEV1.

At the beginning of the study and at each phase of follow-up, children exposed to lower O3 and PM10 concentrations had better lung function values that children exposed to higher concentrations, wrote the researchers.

Strikingly, the effect of pollutant exposure on FEV1 among the children in their study was slighter greater than the effect of exposure to maternal smoking among children in the United States.

The study could not determine the mechanism by which pollutants change lung growth, but other studies have found differences in lung morphology related to O3 exposure, and suggested that chronic exposure to PM and O3 may be associated with small airway disease.

Recently, oxidative stress from oxidant compounds, including O3, NO2 and PM has been identified as a potential cause of an inflammatory response, which could then lead to chronic lung damage. The reversibility of the damage is unclear, but the authors note that previous studies have reported long-term deficits in lung function associated with air pollutants.

Although we could not identify specific sources [of the pollutants], the effect is likely to be due to vehicular exhaust, wrote the researchers, concluding that there is a clear need for stricter air pollution measures in Mexico City to protect lung growth in children living there.


'/>"/>
Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Air pollution affects the heart
2. Pollution could be a risk
3. Pollution- hazardous for diabetics
4. Air Pollution Found To Accelerate Heart Disease
5. Air pollution may raise risk of lung cancer
6. Air pollution hits heart patients during exercise
7. Air Pollution and Heart Attacks
8. Air pollution combined with greater medical needs
9. Traffic pollution linked to severe asthma attacks
10. Air Pollution Tied to Stroke Risk
11. Air Pollution said To Increase Risk of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... "FCPX LUT Intense allows users to cycle ... Christina Austin - CEO of Pixel Film Studios. , With the FCPX LUT ... stylish color grades to their footage. A LUT is a Lookup Table that contains ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Consumer access to ... early June 2016, Kashi®, a maker of whole grain cereals and other plant-based foods, ... Transitional ingredient: hard red winter wheat processed by Hesco/Dakota Organic Products. , The ...
(Date:5/25/2016)... ... , ... Stern Environmental Group , of Secaucus, New Jersey, working in ... Stern’s Real Time Monitoring (RTM) Device. Stern Environmental Group will sell the first ... for use in dormitories, shelters, and nursing homes for real time bedbug monitoring in ...
(Date:5/24/2016)... ... , ... Sterling Global Products is launching a Kickstarter campaign focused on “PAW ... The campaign kick-off video is located via this link https://youtu.be/WsO4qz2odco . The campaign ... to raise $1,000 per day for a total of $25,000. The funds will be ...
(Date:5/24/2016)... ... May 24, 2016 , ... To better understand the impact of lung ... examine gender differences in lung cancer. Today, the Lung Association announced Sharad Goyal, MD ... Women Award, funded by the American Lung Association’s LUNG FORCE initiative, which raises awareness ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
(Date:5/24/2016)... , May 24, 2016 ... beide primären Endpunkte und ... Überlegenheit in ‚ausgezeichneter plus guter ... Colons    ,      (Logo: ... gab heute neue positive Daten von der MORA-Studie ...
(Date:5/24/2016)... , May 24, 2016  NxStage Medical, Inc. (Nasdaq: ... focused on advancing renal care, today announced that ... participate in the following schedule of investor conferences. Where ... available at http://ir.nxstage.com/ .   ... Healthcare Conference NY, NY           Friday, June 10, 2016 ...
Breaking Medicine Technology: