Navigation Links
High pollution linked to poor lung function growth in children in Mexico City
Date:8/15/2007

Children who are chronically exposed to higher levels of air pollution show marked deficiencies in lung growth and function, and not just short-term breathing problems, according to researchers in Mexico.

"Our study revealed significant deficits in lung function growth in children with long-term exposure to air pollutants, wrote Isabelle Romieu, M.D., M.P.H., lead author of the study. "In addition to the important impact of lung health, early lung deficits may increase the risk of developing chronic obstructive lung disease later in life, as well as cardiovascular morbidity and general mortality.

These conclusions are the result of a three-year, multi-site prospective study that measured lung function growth in 3,170 eight-year-old children at 39 schools in Mexico City and analyzed it with respect to the childrens exposure to common urban pollutants: ozone (O3), nitrogen dioxide (NO2), and particulate matter under 10 m (PM10).

Dr. Romieu, of the Instituto Nacional de Salud Publico in Mexico, and eight colleagues reported their findings in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Previous studies have found that short-term exposure to pollutants is associated with acute but reversible deficits in lung function, but the effects of long-term exposure, like that experienced by residents of heavily polluted urban environments, had not been conclusively characterized.

The researchers analyzed forced vital capacity in one second (FVC1); forced expiratory flow, midexpiratory phase (FEF25-75); and forced expiratory volume in one second (FEV1) in the schoolchildren at six month increments over three years to determine the effects of pollutant exposure, which was measured by air monitoring stations within 2 km of the children's schools. They conducted personal exposure assessments on 60 randomly selected children in the study to ensure that the air monitoring station data was an accurate representation of individual exposure.

Although all measurements of lung function increased over time, the researchers found that higher exposure to O3, NO2 and PM10 was significantly associated with growth deficits in FVC and FEV1.

At the beginning of the study and at each phase of follow-up, children exposed to lower O3 and PM10 concentrations had better lung function values that children exposed to higher concentrations, wrote the researchers.

Strikingly, the effect of pollutant exposure on FEV1 among the children in their study was slighter greater than the effect of exposure to maternal smoking among children in the United States.

The study could not determine the mechanism by which pollutants change lung growth, but other studies have found differences in lung morphology related to O3 exposure, and suggested that chronic exposure to PM and O3 may be associated with small airway disease.

Recently, oxidative stress from oxidant compounds, including O3, NO2 and PM has been identified as a potential cause of an inflammatory response, which could then lead to chronic lung damage. The reversibility of the damage is unclear, but the authors note that previous studies have reported long-term deficits in lung function associated with air pollutants.

Although we could not identify specific sources [of the pollutants], the effect is likely to be due to vehicular exhaust, wrote the researchers, concluding that there is a clear need for stricter air pollution measures in Mexico City to protect lung growth in children living there.


'/>"/>
Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Air pollution affects the heart
2. Pollution could be a risk
3. Pollution- hazardous for diabetics
4. Air Pollution Found To Accelerate Heart Disease
5. Air pollution may raise risk of lung cancer
6. Air pollution hits heart patients during exercise
7. Air Pollution and Heart Attacks
8. Air pollution combined with greater medical needs
9. Traffic pollution linked to severe asthma attacks
10. Air Pollution Tied to Stroke Risk
11. Air Pollution said To Increase Risk of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: