Navigation Links
High-normal phosphate levels linked to early atherosclerosis
Date:11/13/2008

Healthy adults with higher levels of phosphate in the blood are more likely to have increased levels of calcium in the coronary arteriesa key indicator of atherosclerosis and future cardiovascular disease risk, reports a study in the February 2009 issue of the Journal of the American Society of Nephrology (JASN).

"Phosphate level may represent a previously unidentified and modifiable cardiovascular risk factor, and could help identify people for whom modifiable risk factors could be screened and managed," comments Robert N. Foley, MD, of University of Minnesota and the US Renal Data System (USRDS), both in Minneapolis, MN.

Dr. Foley and colleagues studied the relationship between phosphate levels and coronary artery calcium in 3,015 healthy young adults from a long-term study of risk factors for coronary artery disease. At an average age of 25 years, the subjects underwent measurement of their serum phosphate level. The phosphate level reflects the mineral phosphorus, which plays an important role in bone metabolism.

A special computed tomography (CT) scan was used 15 years later to measure the level of calcium in the coronary arteries. Coronary artery calcium is an early sign of atherosclerosis, or "hardening of the arteries."

After adjustment for other factors, blood phosphate levels at age 25 were significantly related to coronary artery calcium levels at age 40. Subjects with higher phosphate levels were about 50 percent more likely to be at the highest level of coronary artery calcium, compared to those with lower phosphate levels. The relationship was strongest at higher phosphate levelshowever, phosphate levels were within range of normal for nearly all of the young adults studied.

Patients with kidney disease have increased phosphate levels, which are associated with an increased risk of heart disease. If higher phosphate levels play a role in causing cardiovascular disease, then a link between phosphate level and early atherosclerosis might be found even in healthy people without kidney disease.

"Our findings indicate that phosphate levels in the normal range may be risk factors for coronary artery atherosclerosis," says Dr. Foley. "For physicians and patients, improved understanding of risk factors for heart disease and coronary artery disease provides more opportunity to screen for and modify them."

Another study in the same issue of JASN shows that higher phosphate levels are linked to increased coronary artery calcium in patients with moderate chronic kidney disease (CKD). The two studies raise the possibility that phosphate-lowering drugsgenerally used only in patients with end-stage renal disease on dialysismight help to reduce cardiovascular risk in CKD patients and even in healthy adults with high-normal phosphate levels.

Since the study was not experimental, it cannot establish any cause-and-effect relationship. In addition, it lacked data on some possibly relevant laboratory valuesespecially parathyroid hormone and vitamin D, which, like phosphate, have important effects on bone.


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding
2. How does sodium phosphate combined with bisacodyl affect small intestine?
3. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
4. FDA Advisory Committee Votes in Favor of Earlier Use of Phosphate Binders in Stage 4 Kidney Disease Patients With Hyperphosphatemia
5. Genzyme Statement Regarding Results of FDA Advisory Committee Meeting on the Use of Phosphate Binders in Chronic Kidney Disease
6. High Blood Fat Levels Tied to Ischemic Stroke Risk
7. Lipoprotein Levels May Predict Womens Hypertension Risk
8. Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications
9. REVISED AND UPDATED: Firearms Industry Statement on Results of CDC Blood Lead Levels in Hunters Study
10. Firearms Industry Statement on Results of CDC Blood Lead Levels in Hunters Study
11. Hormone Lowers Glucose Levels in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... As an ... an educational webinar, they will present the line of epMotion automated liquid handling ... easy you can automate everyday pipetting tasks. , Ideal for scientists and lab ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh ... protection assistance to communities in North-Central West Virginia, is embarking on a cooperative ... boys in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Brian Gifford Agency, ... Indiana, is campaigning in support of Campagna Academy in a charity drive to provide ... “Hoosier Boys’ Town of Indiana,” Campagna Academy is a nonprofit organization that has offered ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Emotions are sacred, valid, honored, encouraged. This is ... education company Generation Mindful. To help change the mindset of parents and educators from ... she created the Time-In Toolkit, which launched on Kickstarter 3 weeks ago and fully ...
(Date:8/18/2017)... ... August 18, 2017 , ... Alcovit, a lime-flavored beverage that rids ... marketing efforts with its product now available through Jet.com. , After 25 years ... effervescent powdered drink is designed to quickly detox the body thereby avoiding alcohol-induced hangovers. ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), ... in Lakewood, Colorado . The reputable clinic ... Lipkin , PT, DPT with his staff of four clinicians. ... of Pittsburgh and brings over 10 years of experience with ... Belmar PT marks the 10th PRN clinic in and ...
(Date:8/8/2017)...   Second-quarter 2017 ... loss per share from continuing operations ... 16 percent to $110 million ... to $161 million Second-quarter ... operations increased 8 percent to $0.93 ...
(Date:8/7/2017)... , Aug. 7, 2017 Zimmer Biomet Holdings, Inc. ... today announced that its Board of Directors has approved the ... third quarter of 2017. ... on or about October 27, 2017 to stockholders of record ... Future declarations of dividends are subject to approval of the ...
Breaking Medicine Technology: