Navigation Links
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
Date:10/31/2011

FINDINGS: Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes -- including increased mortality. The researchers also found that invasive ER-positive tumors with elevated levels of this factor, the protein known as heat shock factor 1 (HSF1), tend to be larger and more aggressive than those with low levels.

RELEVANCE: According to the American Cancer Society, approximately two-thirds of breast cancer patients have ER-positive tumors. HSF1 status may shed light not only on prognosis but also on how such patients might respond to specific therapies.

High levels of master heat shock protein linked to poor prognosis in breast cancer patients

CAMBRIDGE, Mass. (October 31, 2011) Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of the ancient cellular survival factor heat shock factor 1 (HSF1) experience poor outcomes -- including increased mortality.

According to the American Cancer Society, approximately two-thirds of breast cancer patients have ER-positive tumors. Although ER-positive breast cancers are often associated with better outcomes than other breast cancer tumor types, including those that are negative for the HER-2 receptor and so-called triple negative breast cancers (those lacking estrogen, progesterone, and HER-2 receptors), patient prognoses can still vary widely.

"HSF1's relationship to prognosis [in ER-positive patients] raises the interesting possibility for diagnostic applications -- HSF1 levels may have a role in helping determine who will have a better outcome and possibly who will have a poorer response to certain drugs," says Sandro Santagata, a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist and first author of the study whose results are published online this week
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Older men with higher testosterone levels lose less muscle mass as they age
2. Teenage girls and senior students suffered highest levels of PTSD after major earthquake
3. Breast Cancer Risk May Rise With High Hormone Levels
4. Elevated hormone levels add up to increased breast cancer risk
5. High to moderate levels of stress lead to higher mortality rate
6. Experts find continuous glucose monitoring beneficial in maintaining target blood glucose levels
7. Small study shows association between medication and reduction in brain amyloid levels related to AD
8. Raising good cholesterol levels reduces heart attack and stroke risk in diabetes patients
9. New study shows inflammatory food toxins found in high levels in infants
10. Hysterectomy is associated with increased levels of iron in the brain
11. Low zinc and copper levels might cause spontaneous abortion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 NEWwoodworks, ... , is expanding their brand presence with a website ... over 20 years, NEWwoodworks has specialized in handcrafted cabinetry, ... interior furnishings. NEWwoodworks has earned a reputation for taking ... dare take on. They commonly craft with reclaimed wood, ...
(Date:7/31/2014)... Ticket Down is a dependable source for authentic ... Sun Life Stadium in Miami on Monday, August 4th. ... and diehard soccer fans from the Miami, Florida area are ... Cup final in person at Sun Life Stadium. ... split into two groups where they will then play each ...
(Date:7/31/2014)... 2014 The VitaSleep FDA cleared ... and provide an easier breathing capacity by slightly adjusting ... that people can breathe easier and helps reduce or ... so that it can meet the needs of each ... often shared by actual customer reviews. Johathan R. ...
(Date:7/31/2014)... Denver, Colorado (PRWEB) July 31, 2014 ... commonly doctors recommend pain killers for this health problem. ... reveals that this new program was created by Peter ... purpose to help sufferers from all over the world ... , If people wish to view pros and ...
(Date:7/31/2014)... 31, 2014 A program for anyone ... to the University of Colorado Anschutz Health and ... loss boot camp and transformation program. , “Extreme ... and Eyeworks USA, is an evidenced-based program inspired by ... by Eyeworks USA. This season, the show has participants ...
Breaking Medicine News(10 mins):Health News:NEWwoodworks Fine Woodworking Group Launches New Website 2Health News:NEWwoodworks Fine Woodworking Group Launches New Website 3Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 2Health News:Guinness International Champions Cup Finals Tickets in Miami, FL Available at Ticket Down 3Health News:New Dental Device Reviews to Stop Snoring by VitalSleep 2Health News:Neuropathy Miracle Review Reveals Peter Bansby's Unique Cure Method 2Health News:"Extreme Weight Loss: Destination Boot Camp" Comes to Colorado - The CU Anschutz Health and Wellness Center Begins Transformational Program 2Health News:"Extreme Weight Loss: Destination Boot Camp" Comes to Colorado - The CU Anschutz Health and Wellness Center Begins Transformational Program 3
... Blue branded dental plan,to central Pennsylvania (Lehigh Valley) ... BlueCross announced,today that it is acquiring Dominion Dental ... The move by the region,s,leading health insurer adds ... the Mid-Atlantic Region., "Helping to improve the ...
... Nov. 4 Hospira, Inc.,(NYSE: HSP ), ... announced that Christopher B. Begley, chairman and chief,executive ... Finance,and chief financial officer, will make a formal ... Conference on Wednesday, Nov. 12, 2008, in,Phoenix., ...
... PH ), the global leader in motion ... the purchase of Matrx nitrous oxide,delivery systems from ... to expand its geographic market space for dental ... American base of operations. The,product line will be ...
... Nov. 4 Allied Minds funds research to ... dermal fillers.,Allied Minds, a seed investment firm specializing ... research with Lawrence Berkeley National,Laboratory through creation of ... Eva Turley and Mina Bissell will develop a,technology ...
... of Minnesota Leverages Market Dynamics With New, Plan Offering ... ... NASHVILLE, Tenn., Nov. 4 ,HealthLeaders-InterStudy, a leading provider of managed ... the,national trend of moving from fully insured to self-insured health plans.,According ...
... Sold by A Uniquely-Trained Sales ... ... today announced that SANCUSO(R) (Granisetron Transdermal System),is now available by prescription for ... approved by,the U.S. Food and Drug Administration (F.D.A.) in September 2008 as ...
Cached Medicine News:Health News:Capital BlueCross Acquires Dominion Dental 2Health News:Parker Acquires Medical Gas Delivery Product Line, Expanding Its Dental Equipment Offering 2Health News:Parker Acquires Medical Gas Delivery Product Line, Expanding Its Dental Equipment Offering 3Health News:New Skin Rejuvenation Discovery Receives Commercial Backing 2Health News:Minnesota Employers Buck National Trend and Largely Remain Fully-Insured 2Health News:SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Chemotherapy Patients, Now Available 2Health News:SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Chemotherapy Patients, Now Available 3
(Date:7/31/2014)... For its innovative modular Biomedical Research building ... Scientific has earned a Modular Building Institute (MBI) 2014 ... 30 categories, MBI,s contest is the commercial modular industry,s ... manufacturers, dealers, and product and service providers. ... of our team," said Dan Palmer , President ...
(Date:7/31/2014)... VIENNA , July 31, 2014 ... in New York results of AFF008, ... Parkinson,s disease. PD01A is the first therapy against the protein ... The Michael J. Fox Foundation for Parkinson,s Research ... and presented at the press conference on the impact a ...
(Date:7/31/2014)... For the first time, cardiac surgeons, medical ... the SynCardia temporary Total Artificial Heart in a peer ... the Journal of Visualized Experiments website. ... the SynCardia Total Artificial Heart implantation   goo.gl/2OZyKW ... the SynCardia Total Artificial Heart," a July 18, 2014 ...
Breaking Medicine Technology:Art's Way Scientific Earns Prestigious Modular Building Institute Award 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 3Art's Way Scientific Earns Prestigious Modular Building Institute Award 4First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3
... JOSE, Calif., June 13, 2011 SI-BONE, Inc. (San Jose, ... of a minimally invasive surgical (MIS) device to treat the ... surgeon training milestone for its iFuse Implant System® with over ... in Europe.  As a result, the medical community,s awareness of ...
... MIAMI, June 13, 2011 Sanomedics International Holdings, Inc. (Pink ... Chairman, with Keith Houlihan, Co-founder and President of Sanomedics ... appointment of Charlie Alvarez, Co-founder and President of Watermark ... "The addition of Charlie to the Sanomedics ...
Cached Medicine Technology:Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 2Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 3Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 4Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 2Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 3
... absolute knowledge. Access it with ... Diagnostic Workstation, uniting two trusted ... and Orbscan IIz Anterior Segment ... critically important data. Together they ...
... LADARWave® device gives you ... measure and display the ... individual eye. This capability ... a better understanding of ...
ZYMAR™ ophthalmic solution is an anti-infective prescription eye drop that your doctor may instruct you to use if you have an eye infection caused by bacteria. Bacterial conjunctivitis is the e...
...
Medicine Products: