Navigation Links
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
Date:10/31/2011

FINDINGS: Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes -- including increased mortality. The researchers also found that invasive ER-positive tumors with elevated levels of this factor, the protein known as heat shock factor 1 (HSF1), tend to be larger and more aggressive than those with low levels.

RELEVANCE: According to the American Cancer Society, approximately two-thirds of breast cancer patients have ER-positive tumors. HSF1 status may shed light not only on prognosis but also on how such patients might respond to specific therapies.

High levels of master heat shock protein linked to poor prognosis in breast cancer patients

CAMBRIDGE, Mass. (October 31, 2011) Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of the ancient cellular survival factor heat shock factor 1 (HSF1) experience poor outcomes -- including increased mortality.

According to the American Cancer Society, approximately two-thirds of breast cancer patients have ER-positive tumors. Although ER-positive breast cancers are often associated with better outcomes than other breast cancer tumor types, including those that are negative for the HER-2 receptor and so-called triple negative breast cancers (those lacking estrogen, progesterone, and HER-2 receptors), patient prognoses can still vary widely.

"HSF1's relationship to prognosis [in ER-positive patients] raises the interesting possibility for diagnostic applications -- HSF1 levels may have a role in helping determine who will have a better outcome and possibly who will have a poorer response to certain drugs," says Sandro Santagata, a postdoctoral researcher in the lab of Whitehead Member Susan Lindquist and first author of the study whose results are published online this week in the Proceedings of the National Academy of Sciences.

The heat shock response, which is controlled by transcription factors like HSF1, enables cells to withstand temperature spikes and other stressors. Crammed with distorted and abnormal proteins, cancer cells are deviants that live in a tumor's distorted landscape; a world lacking abundant nutrients and oxygen. To survive these exceptionally stressful circumstances, many cancer cells have usurped the normally beneficial heat shock response to support their existence.

To see how HSF1 levels in cancer cell nuclei are associated with the cancer's aggressiveness, Santagata examined HSF1 levels in breast cancer tissue samples from 1,841 participants in one of the largest and longest-running epidemiological studies of women's health, the Nurses' Health Study. Santagata and colleagues at the Harvard School of Public Health and University of Miami then looked at the relationship between HSF1 status and the participants' outcomes. Compared with ER-positive breast cancer patients with low levels of HSF1, those with high levels of HSF1 had a poorer outcome, including increased mortality. He also noted that invasive ER-positive tumors with elevated HSF1 levels tended to be larger and more aggressive than those with normal HSF1 levels.

Because of this strong link between HSF1 concentrations and prognosis, HSF1 testing could become a valuable part of the oncologist's toolkit.

"If HSF1 status can help predict which of the ER-positive patients will do well with standard treatments and which ones won't, that would be really helpful," says Santagata, who is also an instructor in pathology at Brigham and Women's Hospital. "In terms of understanding the biology, we think these findings are really important for reinforcing our interest in pursuing the heat shock response itself as a therapeutic target."


'/>"/>
Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert  

Related medicine news :

1. Older men with higher testosterone levels lose less muscle mass as they age
2. Teenage girls and senior students suffered highest levels of PTSD after major earthquake
3. Breast Cancer Risk May Rise With High Hormone Levels
4. Elevated hormone levels add up to increased breast cancer risk
5. High to moderate levels of stress lead to higher mortality rate
6. Experts find continuous glucose monitoring beneficial in maintaining target blood glucose levels
7. Small study shows association between medication and reduction in brain amyloid levels related to AD
8. Raising good cholesterol levels reduces heart attack and stroke risk in diabetes patients
9. New study shows inflammatory food toxins found in high levels in infants
10. Hysterectomy is associated with increased levels of iron in the brain
11. Low zinc and copper levels might cause spontaneous abortion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High levels of master heat shock protein linked to poor prognosis in breast cancer patients
(Date:12/9/2016)... ... December 09, 2016 , ... Flottman ... and outserts. As a means of expanding capabilities Flottman has added a ... to individually code professional inserts (PIs) and patient package inserts (PPIs) that will ...
(Date:12/9/2016)... ... December 09, 2016 , ... Mediaplanet today announces distribution of ... while encouraging readers to sign up as an organ donor for the 123,000 people ... , An organ donor can save up to 8 saves through organ donation and ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West ... January 1, 2017. The name change aligns the entire company with its ... health care quality. , “We are very proud of the achievements associated with ...
(Date:12/8/2016)... JENNERSVILLE, Pa. (PRWEB) , ... December 08, 2016 ... ... Penn Medicine Southern Chester County, a Property owned by an affiliate of Seavest, ... 72,000 square foot Penn Medicine Southern Chester County ambulatory care center (ACC) was ...
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) ... , the ultimate weight loss and wellness program, at their world headquarters of Omni ... provide immediate and long-term results to anyone seeking weight loss, personal development, a healthy ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
(Date:12/8/2016)... -- KEY FINDINGS North America ... in 2016 and is expected to continue in the ... large number of surgical procedures that are taking place ... the patient temperature management market.) Patient warming and cooling ... blood during surgeries, lowering the risks of neurological disorders ...
(Date:12/8/2016)... Research and Markets has announced the addition of the "Endodontic Supplies - ... ... worldwide markets for Endodontic Supplies in US$ Thousand. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... forecasts are provided for the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: