Navigation Links
High levels of circulating DNA may signal faster progression of lung cancer
Date:1/31/2011

High levels of circulating DNA may indicate faster progression of lung cancer and lower overall survival, according to a study published in the February edition of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer (IASLC).

"Thirty-three years ago it was demonstrated that cancer patients presented more free DNA in the blood than healthy people, and further investigations confirmed that much of the circulating DNA in the patients with cancer derives from the tumor," said Rafael Sirera, an associate professor of immunology at the Polytechnic University of Valencia in Valencia, Spain. "Although circulating DNA in established cancers demonstrated a strong power to discriminate patients with lung cancer from those with benign lung diseases or healthy individuals, several critical voices were raised against its relevance for screening and diagnostics."

The study analyzed blood samples from 446 patients with advanced non-small cell lung cancer, all of whom were enrolled in a multicenter clinical trial of the Spanish Lung Cancer Group between February 2003 and January 2005. Levels of free human telomerase reverse transcriptase (hTERT), as a surrogate of circulating DNA, were determined before the planned start of combination chemotherapy with cisplatin and docetaxel.

Patients with hTERT levels below 49.8 nanograms per milliliter (ng/ml) had a median time to progression (TTP) of 6.3 months, compared with 4.9 months for patients with hTERT of more than 49.8 ng/ml.

In addition, patients with the lower hTERT levels had higher overall survival, at 10.9 months versus 9.3 months for patients with higher hTERT.

A key strength of the study was its larger population size, compared with similar studies that included fewer than 100 patients.

"The standardization of sample source, processing, DNA extraction and titration methods gives a strong reliability to our results," Sirera said. "Another important aspect that should be emphasized is that the DNA concentrations in our study did not seem to be influenced by either pretreatment tumor characteristics or clinical variables."

Because hTERT analysis depends on a simple, noninvasive and affordable procedure that can be performed in sequential samples from the same patient, it could be an important aid in therapy evaluations and follow-up of patients with non-small cell lung cancer, Sirera said.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Workers most invested in their jobs have highest stress levels, CAMH study shows
2. Researchers find rising levels of hypertension in older Mexican-Americans
3. U.S. Officials Recommend Reduced Fluoride Levels in Water
4. Neural stem cells maintain high levels of reactive oxygen species, UCLA study finds
5. Healthy Habits in Youth Tied to Better Adult Cholesterol Levels
6. Injectable, Oral Birth Control Dont Threaten Glucose, Insulin Levels: Study
7. Vegetarian Diet Cuts Kidney Patients Levels of Toxic Phosphorus
8. Naturally High Hemoglobin Levels May Not Threaten Kidney Patients
9. Vitamin D and parathyroid hormone levels may not affect cardiovascular mortality
10. Obesity Rising Across All Income Levels: CDC
11. Scientists Raise Fat-Burning Levels in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
Breaking Medicine Technology: