Navigation Links
High levels of circulating DNA may signal faster progression of lung cancer
Date:1/31/2011

High levels of circulating DNA may indicate faster progression of lung cancer and lower overall survival, according to a study published in the February edition of the Journal of Thoracic Oncology, the official publication of the International Association for the Study of Lung Cancer (IASLC).

"Thirty-three years ago it was demonstrated that cancer patients presented more free DNA in the blood than healthy people, and further investigations confirmed that much of the circulating DNA in the patients with cancer derives from the tumor," said Rafael Sirera, an associate professor of immunology at the Polytechnic University of Valencia in Valencia, Spain. "Although circulating DNA in established cancers demonstrated a strong power to discriminate patients with lung cancer from those with benign lung diseases or healthy individuals, several critical voices were raised against its relevance for screening and diagnostics."

The study analyzed blood samples from 446 patients with advanced non-small cell lung cancer, all of whom were enrolled in a multicenter clinical trial of the Spanish Lung Cancer Group between February 2003 and January 2005. Levels of free human telomerase reverse transcriptase (hTERT), as a surrogate of circulating DNA, were determined before the planned start of combination chemotherapy with cisplatin and docetaxel.

Patients with hTERT levels below 49.8 nanograms per milliliter (ng/ml) had a median time to progression (TTP) of 6.3 months, compared with 4.9 months for patients with hTERT of more than 49.8 ng/ml.

In addition, patients with the lower hTERT levels had higher overall survival, at 10.9 months versus 9.3 months for patients with higher hTERT.

A key strength of the study was its larger population size, compared with similar studies that included fewer than 100 patients.

"The standardization of sample source, processing, DNA extraction and titration methods gives a strong reliabili
'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Workers most invested in their jobs have highest stress levels, CAMH study shows
2. Researchers find rising levels of hypertension in older Mexican-Americans
3. U.S. Officials Recommend Reduced Fluoride Levels in Water
4. Neural stem cells maintain high levels of reactive oxygen species, UCLA study finds
5. Healthy Habits in Youth Tied to Better Adult Cholesterol Levels
6. Injectable, Oral Birth Control Dont Threaten Glucose, Insulin Levels: Study
7. Vegetarian Diet Cuts Kidney Patients Levels of Toxic Phosphorus
8. Naturally High Hemoglobin Levels May Not Threaten Kidney Patients
9. Vitamin D and parathyroid hormone levels may not affect cardiovascular mortality
10. Obesity Rising Across All Income Levels: CDC
11. Scientists Raise Fat-Burning Levels in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 Recently, BellasDress ... all its wedding dresses. BellasDress has chosen their best-selling ... gift choices for the holiday season. , Now, ... suitable wedding gowns here at discount prices. The business ... at its website. , “All our elegant ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping tips ... the models at LunaDress.co.uk come with big discounts, up to 80 ... can turn out to be a most exciting memory and can ... bring surprise to a wedding. On the updated fashion blog, ladies ... for a big day . , Going out with friends to ...
(Date:12/25/2014)... -- The risk of burns from fires and cooking ... be extra cautious, an expert says. "Between Thanksgiving ... in patients coming in with burns," said Dr. Steven ... Burn Center of Stony Brook University Hospital in New ... but if not careful, could quickly turn tragic," Sandoval ...
(Date:12/25/2014)... Dec. 24, 2014 (HealthDay News) -- Among early stage ... less than half of one percent will eventually develop ... analysis reveals. The finding comes from a review ... 1998 and 2007, and it suggests that the risk ... what experts had previously thought. "The frequency of ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... ... and recommendation of its membership program by the Southern Medical Association (SMA). As a ... Traveler program, which provides complete medical air transport to the hospital of the member,s ... ...
... that factors known to increase the risk of breast cancer ... Published early online in Cancer , a peer-reviewed journal ... is needed to evaluate how breast cancer risk factors differ ... frequently in certain ethnic and racial groups, but the reasons ...
... select individuals at high risk of developing heart disease, rather ... of age, is just as effective at saving lives but ... bmj.com today. Despite a significant decrease in ... the leading cause of ill health and death in the ...
... According to legend, it was The Fountain of Youth that the ... on the Floridian coast in 1513. It has long been said ... restored. Without a doubt, the quest for eternal youth is as ... than ever, there is now growing concern that quantity of years ...
... ... needs of the Haitian people , ... Palm Beach, FL (Vocus) April 25, 2010 -- The National Association of Chain ... relief effort. The contributions include $50,000 each to organizations that have been immersed in ...
... Los Angeles plastic ... Foundation (ASERF). The Foundation is the research arm of the American Society for Aesthetic ... ... M.D. is the new President of the Aesthetic Surgery Education and Research Foundation (ASERF) ...
Cached Medicine News:Health News:Air Ambulance Company AirMed International Endorsed by Southern Medical Association 2Health News:Air Ambulance Company AirMed International Endorsed by Southern Medical Association 3Health News:Breast cancer risk factors differ among races 2Health News:Selecting high-risk patients for heart screening 2Health News:Better vitamin D status could mean better quality of life for seniors 2Health News:Better vitamin D status could mean better quality of life for seniors 3Health News:NACDS Foundation Contributes $150,000 to Haiti Relief Efforts 2Health News:Los Angeles Plastic Surgeon is the New President of the Aesthetic Surgery and Research Foundation (ASERF), 2Health News:Los Angeles Plastic Surgeon is the New President of the Aesthetic Surgery and Research Foundation (ASERF), 3Health News:Los Angeles Plastic Surgeon is the New President of the Aesthetic Surgery and Research Foundation (ASERF), 4
(Date:12/24/2014)... , Dec. 23, 2014 PuraMed BioScience®, ... of over-the-counter (OTC) medicinal and healthcare products, announced it ... MigraPure® H, a hemp-based, advanced headache relief product, for ... in Colorado , Washington ... With the MigraPure H Advanced headache relief ...
(Date:12/24/2014)... , Dec. 23, 2014 ResMed (NYSE: ... patent infringement action against Chinese medical device manufacturer BMC Medical ... ruled today that BMC,s masks listed below infringe ResMed,s patents, ... selling these masks in the United States ... N2 nasal mask , Willow nasal pillows mask ...
(Date:12/24/2014)... Ohio , Dec. 23, 2014   ... treatment decision support to healthcare providers for behavioral ... it has secured $30 million in equity financing ... Virginia C. Drosos , President and Chief Executive ... clinical adoption and development of Assurex Health,s ...
Breaking Medicine Technology:PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4
... the need for more efficient and cost-effective bariatric surgical ... Endo-Surgery (EES), a global leader in surgical innovations, will ... innovative technologies during the American Society for Metabolic and ... Hotel and Convention Center in Orlando, Florida, June 12-17, ...
... Breckenridge Pharmaceutical, Inc. announced today ... granted final approval for the Company,s Abbreviated New ... of Activella® 0.5mg/0.1mg Tablets. The company currently markets ... Acetate 1.0mg/0.5mg) Tablets. Estradiol/Norethindrone Acetate Tablets ...
Cached Medicine Technology:Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS 2Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS 3Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS 4Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS 5Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS 6
... ZY is a low profile implantable ... for stimulation of either the atrium ... (straight model). All ZY leads are ... is used to extend/retract the fixation ...
The Vitatron Pirouet S+ lead series are endocardial leads with extendable/retractable helical screw designed for reliable fixation and optimal pacing characteristics....
Used with permanent pacing leads....
Implantable medical grade silicone end cap for insulation and sealing protection of 5 mm or 3.2 mm connectors....
Medicine Products: