Navigation Links
High insulin levels tied to obesity pathway, new UT Southwestern research shows
Date:8/25/2014

said Dr. Roth, who holds the Diane and Hal Brierley Distinguished Chair in Biomedical Research. "This result suggests that the high levels of insulin found in those who develop insulin resistance and type 2 diabetes are a contributor to obesity and its complications."

Dr. Roth cautioned that if this response also happens in humans, then treating patients with type 2 diabetes with higher than normal amounts of insulin could contribute to the development of obesity.

The findings suggest that physicians may need to reconsider use of intensive insulin therapy to control hyperglycemia (high blood-sugar levels) in obese, diabetic patients with hyperinsulinemia (overproduction of insulin). In addition, the findings suggest that suppressing glucagon action could prevent hyperinsulinemia, without causing diabetes. The research team found that suppressing glucagon in obese, insulin-resistant, type 2 diabetic mice reduced blood glucose back to normal levels.

Glucagon and insulin normally counteract each other as part of an ongoing effort to stabilize blood-sugar levels. The glucagon hormone is produced and released by the pancreas in response to low concentrations of insulin and, conversely, glucagon release is suppressed by high levels of insulin in the bloodstream. The balance between the two hormones is disrupted in type 2 diabetics by the insulin that is given to control high glucose levels. This excess insulin, in turn, causes the body to produce excess fat. The new findings lead the authors to suggest that the high insulin levels actually aggravate diabetes. The optimal therapy, they propose, should be diet restriction and reducing glucagon levels.

According to estimates of the World Health Organization (WHO), 347 million people worldwide have diabetes, 90 percent of whom are affected by type 2 diabetes. Although previously only seen in adults, type 2 diabetes is now occurring in children, and can include complications such as an incr
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Do closed-loop insulin delivery systems improve blood glucose control in type 1 diabetes?
2. Human Insulin Market by Product Types and Brand Worth $42 Billion by 2019 - New Report by MarketsandMarkets
3. Sensitive acid sensor controls insulin production
4. University of Florida Startup Launches Million-dollar Indiegogo Campaign to Eliminate Painful Needle Injections for Insulin
5. A new way to generate insulin-producing cells in Type 1 diabetes
6. Human Insulin Market Worth $42 Billion by 2019 - New Report by MarketsandMarkets
7. Bionic pancreas outperforms insulin pump in adults, youth
8. Late-breaking observational data show patients with type 2 diabetes taking JANUVIA® (sitagliptin) and metformin initiated insulin therapy at a slower rate compared to patients taking a sulfonylurea and metformin
9. New post-hoc analysis shows patients with type 2 diabetes undergoing intensification of insulin therapy experienced less nighttime hypoglycemia while being treated with Januvia (Sitagliptin) compared to placebo
10. Insulin-producing beta cells from stem cells
11. Tips To Improve Insulin Sensitivity and Avoid Storing Carbohydrates as Fat Released by Health News Wires
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High insulin levels tied to obesity pathway, new UT Southwestern research shows
(Date:8/31/2015)... ... August 31, 2015 , ... Castle Dermatology Institute now ... Dr. Pedram Ghasri is a graduate of the University of California, Los Angeles. He ... studies at the University of California, Irvine Medical School. As a nationally recognized Regents ...
(Date:8/31/2015)... , ... August 31, 2015 , ... In preparation for ... Research, maker of the BEAN™ personal sound amplifier, is offering caregivers “7 Reasons to ... as a way of coping with a variety of home healthcare challenges, specifically as ...
(Date:8/31/2015)... ... August 31, 2015 , ... For 12 years, since ... acknowledged September 26th as Mesothelioma Awareness Day . On this day, and in ... several ways of becoming involved and helping the cause. , “One of the ways ...
(Date:8/31/2015)... ... August 31, 2015 , ... MeYou Health ®, a ... mobile walking app, Walkadoo , by including an in-app step tracker. , ... to each person’s walking habits. Rather than broadly assign every Walkadoo member 10,000 steps ...
(Date:8/31/2015)... ... 2015 , ... It’s a lot like coming home. Life-long Fox Valley resident ... his first days on the job, he’s run into residents of the retirement community ... knowing that they’re living in such a wonderful place,” he said. GreenFields, which is ...
Breaking Medicine News(10 mins):Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 3Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 3Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:Friendship Senior Options Welcomes New Executive Director for GreenFields of Geneva 2
... Benefits and Flavor of Fruit in a Zero-Calorie Fortified Water ... of Fruit2O(R), the original fruit flavored water, comes a new ... nutrients found in two servings of fruit with zero calories ... shown that 80 percent of Americans do not drink the ...
... ... Adoption of Healthcare Information Technology , ... Stamford, CT (PRWEB) June 4, 2009 -- IVANS, Inc. , ... survey that showed healthcare providers believe in the importance of reform, but are concerned ...
... Continued Market Leadership in Parenteral and Solutions/Nutritionals , ... Inc. (B. Braun) today announced that it had received ... highest year-over-year market share growth for distributed products in the ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ...
... overburdened if an outbreak were more severe , THURSDAY, June ... H1N1 swine flu outbreak that surfaced unexpectedly in April has ... , And those shortcomings could take on added urgency if ... fall, a new report found. , "It,s clear that ...
... , , HARRISBURG, Pa., June 4 Pennsylvania ... Estoydecidido.com , a resource tool to help Latino residents ... -- which translates to "I am determined" -- is ... site. , , "Latinos have become an emerging ...
... and the Alzheimer Research Forum announce the release of the ALS ... ), a web-based resource for researchers interested in amyotrophic lateral sclerosis ... The site is modeled on the Alzheimer Research Forum,s popular ... efforts to build a similar set of tools for ALS researchers. ...
Cached Medicine News:Health News:Fruit2O(R) Introduces New 'Essentials' Line 2Health News:Fruit2O(R) Introduces New 'Essentials' Line 3Health News:Providers Believe Healthcare Reform Will Increase Their Costs, According to IVANS Survey 2Health News:Providers Believe Healthcare Reform Will Increase Their Costs, According to IVANS Survey 3Health News:B. Braun Medical Wins Two GHX 2009 Best in Class Awards 2Health News:B. Braun Medical Wins Two GHX 2009 Best in Class Awards 3Health News:Report Gives U.S. Good Grades for Swine Flu Response 2Health News:Report Gives U.S. Good Grades for Swine Flu Response 3Health News:Report Gives U.S. Good Grades for Swine Flu Response 4Health News:Pennsylvania Department of Health Launches Spanish-Language Smoking Cessation Resource Web Site 2Health News:Prize4Life and the Alzheimer Research Forum Announce Launch of New Web-Portal for ALS Research 2Health News:Prize4Life and the Alzheimer Research Forum Announce Launch of New Web-Portal for ALS Research 3
(Date:8/31/2015)... Aug. 31, 2015 With increasing clinical ... experiencing a rise in active partnerships. The primary ... nations to quantitate CD4 cell markers in human ... http://photos.prnewswire.com/prnh/20150831/262206LOGO New analysis ... Flow Cytometry Market ( http://www.frost.com/nf0e ), finds the ...
(Date:8/31/2015)... Pa. , Aug. 31, 2015  The departments ... an event today at Gaudenzia Concept 90 to raise ... drug overdose crisis in Pennsylvania ... treatment and focus on recovery through the Building ... many Pennsylvanians are dying every day to a disease ...
(Date:8/31/2015)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ), the nation,s ... , Chairman & CEO, and Sean Whelan , CFO, ... Mr. Hagerman and Mr. Whelan are scheduled to participate in ... on Wednesday, September 9, 2015 at 1:45 PM ... scheduled to participate in the Robert W. Baird 2015 Healthcare ...
Breaking Medicine Technology:Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Diplomat to Participate in Upcoming Investor Conferences 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: