Navigation Links
High-flux hemodialysis prolongs survival in many patients with CKD
Date:2/20/2009

High-flux hemodialysis (which removes large toxins) reduces the risk of premature death in many patients with chronic kidney disease (CKD), according to a study appearing in the March 2009 issue of the Journal of the American Society Nephrology (JASN). The results suggest that this procedure could be beneficial for those with poor prognoses and those with diabetes.

In patients with CKD, toxins accumulate in the blood because the kidneys lose their ability to eliminate these substances sufficiently. CKD patients undergo either high-flux or low-flux hemodialysis to clear these toxins from the body (high-flux membranes have larger pores that allow for the removal of toxins of greater molecular size). While epidemiological studies have indicated that treatment with high-flux hemodialysis improved survival, the true potential of this treatment on prolonging life has not been clearly determined.

Francesco Locatelli, MD (A. Manzoni Hospital, Lecco, Italy), and his colleagues in eight European countries conducted a clinical trial to investigate the effect of high-flux hemodialysis on patient survival. In a randomized clinical trial called the Membrane Permeability Outcome (MPO) study, they enrolled 738 hemodialysis patients and assigned them to either low-flux or high-flux hemodialysis. Patients were followed for 3 to 7.5 years; in the entire study group the researchers did not detect a significant survival benefit with either high-flux or low-flux hemodialysis, but the use of high-flux membranes conferred a significant survival benefit in higher-risk patients. In addition, patients with diabetes showed a survival benefit with high-flux dialysis.

These findings could lead to potentially valuable clinical benefits for patients with CKD. However, because the benefits in diabetic patients were found only after a post-hoc analysis of the data, Dr. Locatelli's team noted that their results in diabetic patients need to be confirmed by other clinical trials.


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert  

Related medicine news :

1. First NxStage Home Hemodialysis Patients Celebrate Five-Year Anniversary
2. NxStage(R) Achieves Milestone with 3,000 End-Stage Renal Disease Patients Receiving Daily Home Hemodialysis Therapy
3. Frost & Sullivan Honours Redsense Medical With the 2008 European Hemodialysis Emerging Company of the Year Award
4. Renal Solutions, Inc. Announces FDA 510(k) Clearance of New Design of the Allient(R) Sorbent Hemodialysis System for Chronic and Acute Hemodialysis
5. Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients
6. Radiation therapy prolongs life in men with recurrent prostate cancer
7. Golf prolongs life
8. Treating oft ignored non-cancer health issues after cancer diagnosis prolongs survival
9. Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
10. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
11. 2 gene mutations linked to most common brain cancers -- and longer survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-flux hemodialysis prolongs survival in many patients with CKD
(Date:8/18/2017)... ... August 18, 2017 , ... As an industry leader, Eppendorf ... they will present the line of epMotion automated liquid handling system. This automated ... automate everyday pipetting tasks. , Ideal for scientists and lab technicians with no ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh ... protection assistance to communities in North-Central West Virginia, is embarking on a cooperative ... boys in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered ...
(Date:8/18/2017)... IN (PRWEB) , ... August 18, 2017 , ... The ... communities in northwest Indiana, is campaigning in support of Campagna Academy in a charity ... to as the “Hoosier Boys’ Town of Indiana,” Campagna Academy is a nonprofit organization ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Emotions are sacred, valid, honored, encouraged. This ... positive education company Generation Mindful. To help change the mindset of parents and educators ... skills, she created the Time-In Toolkit, which launched on Kickstarter 3 weeks ago and ...
(Date:8/18/2017)... ... August 18, 2017 , ... Alcovit, a lime-flavored beverage that rids the ... efforts with its product now available through Jet.com. , After 25 years of ... powdered drink is designed to quickly detox the body thereby avoiding alcohol-induced hangovers. Whether ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 ... from continuing operations Second-quarter ... $110 million Second-quarter 2017 ... Second-quarter 2017 adjusted diluted ... percent to $0.93 Second-quarter ...
(Date:8/7/2017)...  Endo International plc (NASDAQ: ENDP ) ... all known U.S. mesh product liability claims and that ... remaining U.S. claims at reasonable values. Under the agreements, ... quarter of 2017 and continuing through the fourth quarter ... results, the Company intends to increase its mesh product ...
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall County ... its environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The ... disinfection robot that uses UVC light energy to kill deadly pathogens such as C. ... Tru-D SmartUVC ... Tru-D in action in ...
Breaking Medicine Technology: