Navigation Links
High-fat diet makes mice susceptible to liver injury
Date:11/1/2007

A high fat diet may kill regulatory T cells in the liver, allowing steatosis (simple fatty liver) to develop into steatohepatitis (fatty liver with inflammation), according to the results of a new study in the November issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology).

Nonalcoholic fatty liver disease (NAFLD), a condition related to obesity, can range in severity from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH) to cirrhosis which can lead to death. However, the progression of the disease is not well understood. The prevailing hypothesis suggests two-hits are necessary. The first is prolonged over-nutrition which causes the accumulation of fat in the liver. The second hit has been hypothesized to involve oxidative stress, mitochondrial injury or inflammatory cytokine production involving regulatory T cells (Tregs).

Tregs have recently emerged as a key player in hepatic immune regulation, so researchers, led by Xiong Ma of Johns Hopkins University in Baltimore, sought to determine their role in the pathogenesis of NASH. They hypothesized that regulation by Tregs is decreased in a fatty liver, which makes inflammation worse when the organ is exposed to secondary injury.

To test this hypothesis, they fed adult mice a high-fat diet to induce obesity, steatosis, and insulin resistance similar to that seen in humans. (Mice in the control group were fed a normal diet.) They examined the mices hepatic lymphocyte population by flow cytometry. The researchers then injected the mice with liver inflammation-causing exogenous lipopolysaccarhide (LPS, a bacterial toxin usually presented in the normal intestine and carried to the liver by blood flow), and examined serum and liver tissue of the sacrificed mice.

They found that the hepatic Tregs gradually decreased during the administration of the high-fat diet and, at the end of 8 weeks, the levels were less than half of those in mice who ate a normal diet. The high-fat diet induced simple steatosis, and made the mice more susceptible to the LPS. Those on the high fat diet, who had depleted Tregs, sustained greater liver injury after they were exposed to the LPS.

To our knowledge, this is the first time that Tregs have been linked to the inflammatory process in diet-induced steatosis, the authors report. Interestingly, they also found that the Treg depletion reversed itself when the mice were switched from a high-fat to a normal-fat diet.

In conclusion, our study demonstrates that Tregs may play a critical role in controlling hepatic inflammation, the authors write. We speculate that the depletion of Tregs may be the key event in the transition from simple steatosis to steatohepatitis. Their results also suggest that strategies aimed at increasing the number and/or function of Tregs should be explored to improve the prognosis of NAFLD.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

Related medicine news :

1. High-Fat Diet Can Ward Off Inflammation In The Gut
2. Type 2 Diabetes Is Linked To High-Fat Diet
3. Scientists reveal mechanism behind high-fat, diabetes link.
4. High-Fat, Copper-Rich Diets Associated with Increased Rates of Cognitive Decline
5. High-fat and Sugary Diet Severely Damage Liver and Other Vital Organs
6. Right attitude makes you benefit from exercise
7. Virus makes Hodgkin’s disease more deadl
8. What makes young girls smoke
9. Eating chocolate makes you happy
10. Self control makes stress response easy
11. Useful device makes spinal surgery safer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand ... Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be ... Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... ... Cal Dining at the University of California Berkeley, and other leading institutions in ... the buying power of institutions to change the way animals are raised for ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... manufacturer, has expanded its executive staff with the addition of industry sales leader, ... role, Slott will develop the national distribution and sales network, direct the efforts ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... -- HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy ... team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D ...
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
Breaking Medicine Technology: