Navigation Links
High-fat diet makes mice susceptible to liver injury
Date:11/1/2007

A high fat diet may kill regulatory T cells in the liver, allowing steatosis (simple fatty liver) to develop into steatohepatitis (fatty liver with inflammation), according to the results of a new study in the November issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology).

Nonalcoholic fatty liver disease (NAFLD), a condition related to obesity, can range in severity from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH) to cirrhosis which can lead to death. However, the progression of the disease is not well understood. The prevailing hypothesis suggests two-hits are necessary. The first is prolonged over-nutrition which causes the accumulation of fat in the liver. The second hit has been hypothesized to involve oxidative stress, mitochondrial injury or inflammatory cytokine production involving regulatory T cells (Tregs).

Tregs have recently emerged as a key player in hepatic immune regulation, so researchers, led by Xiong Ma of Johns Hopkins University in Baltimore, sought to determine their role in the pathogenesis of NASH. They hypothesized that regulation by Tregs is decreased in a fatty liver, which makes inflammation worse when the organ is exposed to secondary injury.

To test this hypothesis, they fed adult mice a high-fat diet to induce obesity, steatosis, and insulin resistance similar to that seen in humans. (Mice in the control group were fed a normal diet.) They examined the mices hepatic lymphocyte population by flow cytometry. The researchers then injected the mice with liver inflammation-causing exogenous lipopolysaccarhide (LPS, a bacterial toxin usually presented in the normal intestine and carried to the liver by blood flow), and examined serum and liver tissue of the sacrificed mice.

They found that the hepatic Tregs gradually decreased during the administration of the high-fat diet and, at the end of 8 weeks, the levels were less than half of those in mice who ate a normal diet. The high-fat diet induced simple steatosis, and made the mice more susceptible to the LPS. Those on the high fat diet, who had depleted Tregs, sustained greater liver injury after they were exposed to the LPS.

To our knowledge, this is the first time that Tregs have been linked to the inflammatory process in diet-induced steatosis, the authors report. Interestingly, they also found that the Treg depletion reversed itself when the mice were switched from a high-fat to a normal-fat diet.

In conclusion, our study demonstrates that Tregs may play a critical role in controlling hepatic inflammation, the authors write. We speculate that the depletion of Tregs may be the key event in the transition from simple steatosis to steatohepatitis. Their results also suggest that strategies aimed at increasing the number and/or function of Tregs should be explored to improve the prognosis of NAFLD.


'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

Related medicine news :

1. High-Fat Diet Can Ward Off Inflammation In The Gut
2. Type 2 Diabetes Is Linked To High-Fat Diet
3. Scientists reveal mechanism behind high-fat, diabetes link.
4. High-Fat, Copper-Rich Diets Associated with Increased Rates of Cognitive Decline
5. High-fat and Sugary Diet Severely Damage Liver and Other Vital Organs
6. Right attitude makes you benefit from exercise
7. Virus makes Hodgkin’s disease more deadl
8. What makes young girls smoke
9. Eating chocolate makes you happy
10. Self control makes stress response easy
11. Useful device makes spinal surgery safer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... Conrad ... annual Medical and Prescription Drug survey , an employee benefits ... which was conducted in December 2015, indicates that employers are turning to consumer ...
(Date:5/25/2016)... ... ... America Walks , a national advocacy organization that promotes walking and walkable ... Graduate School of Public Health , has been awarded a Walking College ... the country to participate in a four-month training program designed to strengthen local efforts ...
(Date:5/25/2016)... ... 25, 2016 , ... Laser Skin & Wellness Center is excited ... time of female aging. The Juliet™ procedure helps to reverse the ... leakage, laxity, itchiness and pain have reported real relief from these and other problems ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... insurance, has seen a significant spike in their clients' employee participation for their ... biometric health screening by implementing a high-deductible health plan with outcome-based deductible incentives. ...
(Date:5/25/2016)... ... ... Consumer access to organic foods and grower access to food processers is ... cereals and other plant-based foods, will introduce the first consumer product (a new breakfast ... Hesco/Dakota Organic Products. , The transitional designation means the cereal was made using at ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help doctors ... a global scale. Medical professionals from Europe , ... the US have already signed up for the app, which combines ... environment. Education  "Imagine a doctor for Medicines ... at Harvard to treat a bomb victim via live streaming - ...
(Date:5/23/2016)... -- Global Paclitaxel Market 2016 Industry Research ... and the Paclitaxel analysis in this study is supported ... its players. This is the latest Paclitaxel ... current state of the industry while providing a basic ... industry chain structure. The Paclitaxel market analysis is provided ...
(Date:5/23/2016)... NEW YORK , May 23, 2016 /PRNewswire/ ... Mass Spectrometry Market Size, Share, Development, Growth and ... Platform (Hybrid, Single and Other), by Application (Drug ... Others), by End Users (Pharmaceuticals, Life Science and ... Published by P&S Market Research, the global ...
Breaking Medicine Technology: