Navigation Links
High-fat diet and lack of enzyme can lead to heart disease in mice
Date:9/12/2011

f Texas Southwestern Medical Center showed that if HDAC3 were deleted in heart tissue in the middle of embryonic development, the animals developed severe thickening of the heart walls (hypertrophic cardiomyopathy) that reduces the organ's pumping efficiency. These animals usually died within months of birth.

Lazar and his team wanted to know what would happen if the gene was inactivated in heart tissue after birth. To their surprise, they found that these animals were essentially normal.

On a diet of regular chow, the engineered mice lived as long as their normal littermates, although they did tend to accumulate fat in their heart tissue. On a high-fat diet, however, these animals deteriorated rapidly, dying within a few months of hypertrophic cardiomyopathy and heart failure.

To understand why, Lazar's team compared the gene expression patterns of young mutant mice to their normal siblings. They found that the mutant mice tended to underexpress genes important in fat metabolism and energy production. Essentially, on a high-fat diet, these animals' hearts cannot generate enough energy and thus cannot pump blood efficiently.

According to Lazar, this study identifies an "interesting and dramatic example" of the link between diet and epigenetics. Now his team is working to identify the molecular nature of that link. They are also investigating whether the same pathway and interaction occurs in humans since it may contribute to the increased heart disease associated with Western diets.

Whatever the outcome of those studies, says Lazar, there is one sure-fire intervention people can always use to stave off the ravages of over-nutrition: Changing your diet. "We don't want to forget that that's still a noble thing to strive for," he says.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Gastric Bypass May Dampen Desire for High-Fat Foods
2. Eating a high-fat diet may rapidly injure brain cells that control body weight
3. Low-Carb, High-Fat Diets May Not Pose Risk to Arteries
4. High-fat diet during pregnancy programs child for future diabetes
5. Study reinforces link between obesity, high-fat meals and heart disease
6. Greater obesity in offspring of nursing mothers consuming a high-fat diet
7. A high-fat diet alters crucial aspects of brain dopamine signaling
8. High-fat ketogenic diet effectively treats persistent childhood seizures
9. High-Fat Meal May Trigger Asthma
10. High-fat ketogenic diet to control seizures is safe over long term
11. Inhibiting key enzymes kills difficult tumor cells in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-fat diet and lack of enzyme can lead to heart disease in mice
(Date:1/22/2015)... Deer Path of Huntley -- a BMA affordable assisted ... 3 p.m. to 4 p.m. on Feb. 13. , The community, ... adults with physical disabilities between the ages of 22 and 64. ... and sweetheart-themed karaoke. , For more information about the event or ...
(Date:1/22/2015)... LunaDress, with its top dressmaking technologies, has ... the business is showing its latest designs of wedding dresses ... to the company’s CEO, all the fresh new products are ... discounts, up to 80% off. All the clothes from LunaDress ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release ... for kids with cancer. The Chemo Duck App, available on iTunes ... enjoyable games to help children of all ages living with cancer ... keep kids entertained, educated and at ease while waiting for clinic ...
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... Breast cancer patients treated with intensity modulated radiation therapy ... a lower incidence of acute or chronic toxicities, according ... ( PRO ), the official clinical practice journal of ... constantly conducting studies to determine the most effective breast ...
... By Alan Mozes HealthDay Reporter , MONDAY, March ... procedures to standard diabetes treatments contends that surgery is more ... finding stems from two years of tracking 60 severely obese ... ages of 30 and 60. One-third of the patients were ...
... on 31 March when the ship and crew reach Lorient, ... across all the world,s major oceans to sample and investigate ... Karsenti in an editorial published today in Molecular Systems ... yet we know very little about the distribution of marine ...
... HealthDay Reporter , MONDAY, March 26 (HealthDay News) -- ... lowered LDL cholesterol levels in patients with high cholesterol ... treatment could help lower levels of "bad" cholesterol for ... the commonly prescribed cholesterol-lowering drugs known as statins. It ...
... (HealthDay News) -- Antibiotics can prolong cystic fibrosis patients, ... in their lungs, a new, small study suggests. ... not prove, that the current standard of aggressive antibiotic ... the best approach. It,s common to use antibiotics ...
... HealthDay Reporter , MONDAY, March 26 (HealthDay News) -- ... that people who eat chocolate regularly are somewhat skinnier than ... don,t prove that chowing down on chocolate will melt off ... for the modest difference in body mass, or it might ...
Cached Medicine News:Health News:IMRT reduces risk of side effects in breast cancer patients 2Health News:Weight-Loss Surgeries May Beat Standard Treatments for Diabetes 2Health News:Weight-Loss Surgeries May Beat Standard Treatments for Diabetes 3Health News:Weight-Loss Surgeries May Beat Standard Treatments for Diabetes 4Health News:TARA OCEANS completes 60,000-mile journey to map marine biodiversity 2Health News:New Injection Might Lower Tough-to-Treat Cholesterol 2Health News:New Injection Might Lower Tough-to-Treat Cholesterol 3Health News:Should Cystic Fibrosis Patients Get So Many Antibiotics? 2Health News:Does Chocolate Help You Stay Slim? 2Health News:Does Chocolate Help You Stay Slim? 3
(Date:1/23/2015)... analysis of Centers for Medicare and Medicaid Services, (CMS) ... percent of seniors chose lower-cost preferred pharmacy plans that ... The findings were released by Drug Channels . ... of Medicare Part D," said Pharmaceutical Care Management Association ...
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, Inc. ... Biotechnology, Inc. for the compounding, packaging and distributing of its ... the United States . ... of compounding naltrexone tablets in various strengths for individual patients ...
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... 2011 /PRNewswire-Asia-FirstCall/ -- Mindray Medical International Limited (NYSE: ... of medical devices worldwide, announced today an agreement to ... Technical Development Co. Ltd. The terms of the transaction ... Mindray,s financial statements. Founded in 2004 and ...
... Nev., Feb. 28, 2011 PDL ... financial results for the fourth quarter and full year ended ... were $345.0 million, compared to $318.2 million in 2009.  Excluding ... royalty revenues for 2010 increased 30 percent over 2009.  For ...
Cached Medicine Technology:Mindray Medical to Acquire a Controlling Stake in Shenke Medical 2Mindray Medical to Acquire a Controlling Stake in Shenke Medical 3Mindray Medical to Acquire a Controlling Stake in Shenke Medical 4PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 2PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 3PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 4PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 5PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 6PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 7PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 8PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 9PDL BioPharma Announces Fourth Quarter and Full Year 2010 Financial Results 10
...
Ascent Primary Knee System with cruciate retaining, posterior stabilized and constrained components...
... tricompartmental total knee prosthesis stems from many ... design and manufacturing technologies have been used ... as well as a favorable pressure distribution ... keep wear to a minimum. The inherent ...
The Natural-Knee Family is a complete range of interchangeable, anatomically-designed implants with over 14 years of proven clinical results....
Medicine Products: