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High-energy ultrasound sharpens view of liver tumors
Date:1/7/2008

DURHAM, N.C. -- A high-energy form of ultrasound imaging developed by researchers at Duke University's Pratt School of Engineering produces pictures of liver tumors that are better than those made with traditional ultrasound, according to results of a clinical study.

The study suggests that the imaging method known as Acoustic Radiation Force Impulse (ARFI) ultrasound might offer a new tool for screening patients at increased risk for liver cancers, according to the researchers. They say it might also play a useful role in guiding biopsy procedures and minimally invasive therapies aimed at destroying cancerous tissues found deep in the abdomen.

The researchers reported their findings Jan. 7 in the journal Physics in Medicine and Biology. The work was funded by the National Institutes of Health with system support from Siemens Medical Solutions.

First developed six years ago by Duke biomedical engineers Gregg Trahey and Kathy Nightingale, ARFI uses high-energy sound waves to push on tissues like sonic fingers. A tracking beam then captures the movement of the tissue, providing a measure of its elasticity or stiffness.

"To our knowledge, these are the first images of abdominal malignancies in humans that show tissue elasticity," said Trahey, professor of biomedical engineering, radiology and medical physics at Duke. The preliminary findings, which represent the Ph.D. thesis work of Trahey's former graduate student Brian Fahey, have already led Siemens to pursue a product prototype that will combine traditional ultrasound with ARFI, he added.

In general, primary liver cancers are soft while those that have spread from other organs are hard. ARFI may be able to tell the difference between hard and soft tumors, Trahey said. "If borne out in further studies, [that discriminating ability] suggests that ARFI may be useful in guiding treatment decisions."

"All current imaging methodsincluding CT, MRI and ultrasoundh
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Contact: Kendall Morgan
kendall.morgan@duke.edu
919-660-8414
Duke University
Source:Eurekalert

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