Navigation Links
High doses of ursodeoxycholic acid ineffective for NASH patients
Date:7/20/2010

A study conducted by researchers at Johann Wolfgang Goethe University in Frankfurt, Germany found that high doses of ursodeoxycholic acid (UDCA), suggested by some studies to have a beneficial effect on nonalcoholic steatohepatitis (NASH), does not improve overall histology in these patients. Full findings of this study are published in the August issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD).

According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NASH ranks as one of the major causes of cirrhosis in America, behind hepatitis C and alcoholic liver disease. Liver transplantation is the only treatment for advanced cirrhosis with liver failure, and transplantation is increasingly performed in people with NASH. Currently, there are no specific therapies for NASH.

Small, open label clinical studies have shown that UDCA positively influenced liver function tests and liver histology in NASH patients, but a two-year prospective double-blind trial with 166 patients at the dosage of 13󈝻mg/kg body weight per day failed to confirm these results. To determine if the dosage of UDCA may have been too low and a reduction of body weight could have contributed to the results, the German research team initiated a multicenter, placebo-controlled double-blind trial with a high dose of UDCA and without weight-lowering diet.

A UDCA dose of 23-28 mg/kg body weight or placebo was administered daily in three divided doses to 147 randomized patients of both sexes, aged 18 years and older. No special diet was recommended and the body weight of the patients remained constant during the study period. The total treatment time for each patient was 18 months. The primary objective was improvement of liver histology by at least 3 points. Secondary criteria were single histological variables and liver biochemistry.

Pre- and post-treatment liver biopsies
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
2. Children with food allergies should carry 2 doses of emergency medicine
3. Botox reduces wrinkles even in less frequent doses
4. High doses of antioxidant supplements induce stem cell genetic abnormalities
5. Organic Clothing – Is Your Clothing Delivering Death in Small Doses?
6. Cumulative Radiation Doses Seen in Cardiac Imaging
7. Yearly Chlamydia Screening May Be Ineffective for Some
8. Glucosamine Ineffective for Lower Back Pain Linked to Arthritis
9. ICU Patients at Risk for Rare Heart Rhythm Problem
10. Young patients with chronic illnesses find relief in acupuncture
11. For Some Breast Cancer Patients, Shorter Radiation Works Well
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... 17, 2014U.S. military personnel who served in Iraq ... traumatic brain injury (TBI) were compared to military ... medical reasons. Differences in measures of overall disability, ... after injury are reported in an article in ... from Mary Ann Liebert, Inc., publishers. The article ...
(Date:4/17/2014)... estimated that as many as 10 million older Americans ... loneliness and isolation. , However, new research a ... older Americans for six years found that Internet ... depression by more than 30 percent. , "That,s a ... University professor of telecommunication, information studies and media who ...
(Date:4/17/2014)... about one in five infants in the United States ... first several months after birth. Research into probiotic use ... the April 1, 2014 issue of the British ... study, "Probiotics and Infant Colic," concluding that the use ... colic did not reduce crying or fussing in ...
(Date:4/17/2014)... School of Medicine (BUSM) have discovered that the ... experimental model. The findings, reported in the ... may lead to more effective treatments for alcoholism. ... the leading causes of illness and death in ... by limiting the productivity of workers and necessitating ...
(Date:4/17/2014)... (SACRAMENTO, Calif.) An international team led by researchers ... protein complex, which plays a key role in cell ... process. This is the first time the complex has ... could make cyclin B1/Cdk1 an excellent target to control ... medicine. The research was published online today in the ...
Breaking Medicine News(10 mins):Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2
... Earns 510(k) Clearance for AutoLITT(TM)KALAMAZOO, Mich., and WINNIPEG, Manitoba, ... investigational use at both The Cleveland Clinic and University ... brain tumor patients and has earned clearance from the ... The first applications of the technology are expected ...
... for all health data processing and transactionsPARSIPPANY, ... healthcare EDI company that processes insurance transactions ... has achieved full accreditation with the Healthcare ... Healthcare Network Accreditation Commission (EHNAC). EHNAC,s HNAP ...
... nonprofit leader in ending homelessness at its roots, today ... Council, a group of some of the nation,s leading ... Council members, many of whom are veterans themselves, will ... experience to enable Jericho to serve veterans from all ...
... IBM (NYSE: IBM ) today announced that ... Excellence located in La Gaude, France. (Logo: ... global healthcare capability, the Centre of Excellence will help ... sciences solutions that improve care delivery, predict and prevent ...
... Medical Center-University surveyCHARLOTTE, N.C., May 13 Dr. ... a top score for plastic surgery in the ... a tremendous honor for Dr. Capizzi and his ... coordinates the program and selects the honorees. "The ...
... In U.S., 40 percent of new moms aren,t married, CDC ... The number of unmarried women having children has risen sharply ... U.S. health officials. , In the United States, 40 percent ... these are to women in their 20s, not teenagers, according ...
Cached Medicine News:Health News:Treating Untreatable Brain Tumors: FDA Approves New Laser Surgery 2Health News:MD On-Line, Inc. Receives EHNAC Healthcare Network Accreditation 2Health News:MD On-Line, Inc. Receives EHNAC Healthcare Network Accreditation 3Health News:Jericho Project Creates Veterans Advisory Council 2Health News:Jericho Project Creates Veterans Advisory Council 3Health News:Jericho Project Creates Veterans Advisory Council 4Health News:IBM Establishes Global Healthcare Centre of Excellence in La Gaude, France 2Health News:IBM Establishes Global Healthcare Centre of Excellence in La Gaude, France 3Health News:Dr. Peter J. Capizzi of Stillwater Plastic Surgery Honored in Patient Satisfaction Survey 2Health News:More Single Women Are Having Babies 2Health News:More Single Women Are Having Babies 3Health News:More Single Women Are Having Babies 4
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... Advanced Drug Delivery Systems -- Focus on ... STUDY OBJECTIVES A ...
(Date:1/15/2014)... , Jan. 15, 2014  A novel wearable injector slightly larger ... painless for patients to self-inject prescription drugs in the large ... cancer, blood diseases, autoimmune deficiencies, and genetic disorders.  ... to $220B by 2018, according to analysts.   Many of these ...
(Date:1/14/2014)... InformEx, North America,s leading business partnering ... the 30 th edition of its annual conference at ... January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... and specialty chemical companies will take part in the conference, ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... DIEGO, Calif. and RESEARCH TRIANGLE PARK, N.C. ... (Nasdaq: OREX ), a biopharmaceutical company focused on ... a global provider of drug development and manufacturing services, ... Contrave® (naltrexone HCL sustained release (SR)/bupropion HCL SR) as ...
... Inc. (Headquarters: Woodcliff Lake, New Jersey , Chairman and CEO: Hajime Shimizu , "Eisai") today announces ... (Headquarters: Baltimore, Maryland , Director: John Griffin , M.D., "BSI") related to Eisai,s GCPII (glutamate carboxypeptidase ... ... , ...
Cached Medicine Technology:Orexigen(R) Therapeutics and Patheon Announce Exclusive Manufacturing Agreement for Contrave(R) 2Orexigen(R) Therapeutics and Patheon Announce Exclusive Manufacturing Agreement for Contrave(R) 3Orexigen(R) Therapeutics and Patheon Announce Exclusive Manufacturing Agreement for Contrave(R) 4Orexigen(R) Therapeutics and Patheon Announce Exclusive Manufacturing Agreement for Contrave(R) 5Eisai Enters Licensing Agreement with Johns Hopkins Brain Science Institute 2Eisai Enters Licensing Agreement with Johns Hopkins Brain Science Institute 3
... Retractor System represents the most widely ... Its wide array of retraction components ... versatile system for multi-directional exposure of ... are available for specific procedures: IMA ...
Rainbow technology combines the latest in system theory, adaptive signal processing and a revolutionary sensor that employs eight wavelengths of light to collect and analyze an extraordinarily rich s...
... real-time PCR analysis of gene expression ... LightCycler 480 System combines amazing speed ... the needs of a broad range ... including array validation, gene-knockdown studies, and ...
... PyGON now offers a very unique product series, ... alarm dialing for refrigerators and freezers. This is ... only a phone line. With our VM500 solution ... to 128 points over one phone line. The ...
Medicine Products: