Navigation Links
High-dose radiation improves lung cancer survival, U-M study finds
Date:4/8/2009

ANN ARBOR, Mich. Higher doses of radiation combined with chemotherapy improve survival in patients with stage III lung cancer, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.

Standard treatment for this stage of lung cancer when the tumor is likely too large to be removed through surgery involves a combination of radiation therapy with chemotherapy. But, this new study finds, giving chemotherapy at the same time as the radiation enhances the effect of both. Further, increasing the dose of radiation over the course of treatment also increased survival.

"When patients are diagnosed with stage III lung cancer, surgery is often not an option, and survival rates are typically quite low. Finding new ways to improve survival, even in small increments, is crucial," says senior study author Feng-Ming Kong, M.D., Ph.D., associate professor of radiation oncology at the U-M Medical School and chief of radiation oncology at the Ann Arbor VA Healthcare System.

The study, published in the April 1 issue of the International Journal of Radiation Oncology*Biology*Physics, looked at 237 patients who had been treated for stage III non-small cell lung cancer at U-M and the VA Ann Arbor.

The researchers compared survival among patients treated with radiation alone, with radiation followed by chemotherapy, and with radiation and chemotherapy given at the same time. Thirty-one of the patients were also enrolled in a study in which the radiation dose was increased throughout the course of the treatment.

Patients treated with radiation alone had the worst overall survival rates, living only an average 7.4 months after diagnosis. Adding chemotherapy increased survival to 14.9 months when it was administered after completing radiation and 15.8 months when administered at the same time as radiation. After five years, 19.4 percent of the patients receiving concurrent chemotherapy were still alive, compared to only 7.5 percent of patients receiving sequential chemotherapy.

"Our study shows chemotherapy helps, and high dose radiation helps. But it's challenging to administer these treatments at the same time because of the potential toxicity associated with the high dose radiation," Kong says.

U-M researchers are currently looking at using PET imaging during the course of lung cancer treatment to personalize high dose radiation therapy in many individual patients. As the tumor becomes smaller during treatment, increasing the radiation dose will become more tolerable because it is targeting a smaller area. The U-M researchers believe this strategy could lead to improved treatment outcomes in many patients. Kong currently leads a clinical trial that is following patients through their treatment to look at the impact on survival of increasing radiation dose.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Acute gastric injury due to high-dose analgesics?
2. High-Dose Flu Shot Benefits Elderly
3. LSUHSC study finds high-dose HBO2 therapy extends survival window after cardiopulmonary arrest
4. Resveratrol: Thousands of Bottles of Wine, High-Dose Pills Not Required; Mega-doses May Induce Side Effects
5. Study shows that high-dose, high-frequency interferon produces no additional benefit
6. High-Dose Chemo Fails Against Small Cell Lung Cancers
7. High-Dose Chemo Helps Beat Rare Brain Cancer
8. High-Dose Chemo Provides Little Benefit to Breast Cancer Patients
9. High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer
10. Radiation dose can be reduced for triple rule-out coronary CT angiography
11. Radiologists can dramatically lower cardiac CT radiation dose in some patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Castle Dermatology Institute is now offering liquid ... a more youthful appearance to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, ... of other treatments, to rejuvenate and renew the facial appearance. , Sculptra is ...
(Date:12/7/2016)... , ... December 07, 2016 , ... They are musicians ... sisters and wives, brothers and fathers, from New England and around the nation. What ... stigma, and are brought together in a beautiful and compelling new photographic exhibit debuting ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Cliff Hart ... in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington Hills, is ... for a brain tumor. , Jason Bauer and his family are longtime members ...
(Date:12/7/2016)... ... ... One of two inventors from Glen Burnie, Md., has a granddaughter who uses ... why the co-inventor and I have designed a new and better way to secure ... the patent-pending AV-AIR, a device that serves as an alternative to conventional methods of ...
(Date:12/7/2016)... ... OCTOBER XX, 2016 (PRWEB) (PRWEB) December 07, 2016 , ... ... entitled “Canine Filamentous Dermatitis Associated with Borrelia Infection” reveals that ... was published in the prestigious Journal of Veterinary Science & Medical Diagnosis. , ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- Global Cervical Dysplasia Market: Scope and Methodology ... market analyzes the current and future prospects of ... summary, including a market snapshot that provides overall ... research is a combination of primary and secondary ... research efforts along with information collected from telephonic ...
(Date:12/7/2016)... 2016  Palatin Technologies, Inc. ("Palatin") (NYSE MKT: ... previously disclosed underwritten public offering of units with ... sole book-running manager, Roth Capital Partners acted as ... co-manager for the offering. "This financing ... proceeds, allowing us to continue advancing bremelanotide for ...
(Date:12/7/2016)... NEW YORK , Dec. 7, 2016 /PRNewswire/ ... This report on pulmonary drugs studies the current ... globally. The stakeholders of this report include companies ... of various pulmonary/respiratory drugs and/or drug-device combinations as ... market. This report comprises an elaborate executive summary ...
Breaking Medicine Technology: