Navigation Links
High-dose melphalan and autologous stem cell transplantation increases survival
Date:10/26/2011

Boston - A team of researchers led by Boston University School of Medicine (BUSM), has found treatment of selected immunoglobulin light chain (AL) amyloidosis patients with high-dose melphalan and autologous stem cell transplantation (HDM/SCT) resulted in a high organ response rate and increased overall survival (OS), even for those patients who did not achieve a hematologic complete response (CR). These findings appear in the current issue of Blood.

AL amyloidosis is the most common form of systemic amyloidosis, with an incidence of five to 12 persons per million per year. In AL amyloidosis, clonal bone marrow plasma cells produce monoclonal light chains that misfold and deposit in tissues and organs as amyloid fibrils, resulting in progressive system and organ failure and ultimately in death.

Untreated patients with this disease have a dismal outcome, with a median survival of 10-14 months from diagnosis. Moreover, fewer than five percent of patients survived for 10 years before the introduction of HDM/SCT.

The BUSM researchers analyzed a series of 421 patients treated with HDM/SCT and compared outcomes for patients with and without CR. Treatment related mortality was 11.4 percent overall (5.6 percent in the last 5 years). The CR rate was 34 percent and the median event-free survival (EFS) and OS were 2.6 and 6.3 years, respectively.

Eighty-one patients died within the first year after HDM/SCT and were not evaluable for hematologic and organ response. Of 340 evaluable patients, 43 percent achieved CR and 78 percent of them experienced an organ response. For CR patients, median EFS and OS were 8.3 and 13.2 years, respectively. Among the 195 patients who did not obtain CR, 52 percent achieved an organ response, and their median EFS and OS were 2 and 5.9 years, respectively.

"This study provides the longest outcome data on AL patients treated with HDM/SCT, including OS, EFS, and long-term mortality," explained senior author Martha Skinner, MD, former director of BUSM's Amyloid Treatment and Research Program as well as a professor of medicine at BUSM. "Our results demonstrate that, with careful patient selection and experienced management, low rates of treatment related mortality can be achieved.

According to the authors, despite the importance of attaining CR, achievement of partial response often results in a long period of stable or improved diseases. "We pioneered HDM/SCT treatment for AL amyloidosis in 1994. This long term review shows durable hmetologic and organ responses for most patients with an overall survival greatly exceeding what it was prior to HDM/SCT treatment," she added.


'/>"/>
Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. High-Dose Statins May Increase Diabetes Risk
2. Jefferson doctors strengthen case for high-dose radiotherapy technique after radical prostatectomy
3. New model may simplify high-dose radiosurgery planning
4. High-Dose Vitamin B Risky for Diabetics With Kidney Disease
5. Autologous Bone Marrow Stem Cells Transplant into Parkinson's Disease Patients is Safe and May Improve Their Quality of Life
6. Lab-made skin cells will aid transplantation, cancer, drug discovery research
7. Living donor liver transplantation improves survival over deceased donor transplants
8. Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells
9. CDC Moves to Make Organ Transplantation Safer
10. Bone marrow transplantation may increase cancer resistance in patients
11. Study finds important risk factors for death/transplantation in children with heart muscle disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2017)... ... July 28, 2017 , ... Mirror Mirror Beauty Boutique was ... the most successful CoolSculpting practices across the country are annually honored. This marks ... coveted Diamond Level status, the highest ranking possible. , CoolSculpting is a ...
(Date:7/28/2017)... LAND O' LAKES, FL (PRWEB) , ... July ... ... Acute Care Hospital (LTACH) received the Vapotherm Center of Excellence designation for use ... is the highest recognition a facility can receive from Vapotherm, and signifies that ...
(Date:7/28/2017)... ... July 28, 2017 , ... Nominated for ... Chain Partners for 2017. MEBC received numerous client nominations from customers who ... Berger, SupplyChainBrain’s publisher, says “For 15 years running, SupplyChainBrain has published our much-anticipated ...
(Date:7/28/2017)... , ... July 28, 2017 , ... James M. Maisel, ... to have chaired the Epidemiology and Prevention of Diabetes section at the 5th World ... also chairman of Retina Group of New York and recipient of the Juvenile Diabetes ...
(Date:7/28/2017)... ... 28, 2017 , ... The United States Department of Agriculture ... programs. , Right now the most public debate is over the Supplemental Nutrition ... are under consideration, including WIC (Women, Infants, and Children), which is the country’s ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ( ... development of oral drug delivery systems, announced today that ... to schedule an End-of-Phase II meeting with Oramed for ... insulin capsule ORMD-0801 in the treatment of type 2 ... endpoints by indicating a statistically significant lowering of glucose ...
(Date:7/10/2017)... 10, 2017 The Institute for In Vitro ... the recipient of a VITROCELL® inhalation exposure system thanks ... Consortium. The device, which is designed to replace animals ... lung cells to airborne test materials in an environment ... VITROCELL® system for testing combustible tobacco products, as well ...
(Date:7/10/2017)... , July 10, 2017  The tenth annual ... Boston, MA at the Sheraton Boston ... and unparalleled access to global decision makers and innovative ... 800+ life science leaders during two impactful days. BioPharm ... provides delegates with additional networking opportunities with 4,500+ life ...
Breaking Medicine Technology: