Navigation Links
High-dose fluticasone effective against eosinophilic esophagitis
Date:7/18/2014

Results from a clinical trial show that high doses of the corticosteroid fluticasone propionate safely and effectively induce remission in many people with eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus characterized by high levels of white blood cells called eosinophils. However, some trial participants did not respond to fluticasone even after six months of high-dose treatments, providing evidence that certain people with EoE are steroid-resistant. By analyzing gene expressionthe degree to which certain genes are turned on or offin esophageal tissues, the scientists identified a cluster of genes that may help predict steroid responsiveness. The study, led by Marc Rothenberg, M.D., Ph.D., of Cincinnati Children's Hospital Medical Center and the University of Cincinnati, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

EoE affects an estimated 1 in 2,500 people. Symptoms vary, and may include trouble swallowing and abdominal pain. Based on previous research by Dr. Rothenberg and others, physicians typically use oral fluticasone off-label to treat patients with EoE, but studies have shown that some patients do not respond to 880-microgram daily doses of the drug. In the current study, researchers evaluated the effectiveness of a higher dose in adults and children with EoE. For three months, 28 participants swallowed 1760 micrograms of fluticasone each day, while 14 received placebo. At the end of the three-month period, 65 percent of participants who took the drug were in complete remission, based on the near absence of eosinophils in their esophageal tissues, compared to none who took placebo. Those in remission were switched to 880 micrograms of daily fluticasone for an additional three months,
'/>"/>

Contact: Hillary Hoffman
hillary.hoffman@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Predicting outcome for high-dose IL-2 therapy in cancer patients
2. Reducing Unnecessary and High-dose Pediatric CT Scans Could Cut Associated Cancers by 62 Percent
3. High-Dose Statins Linked to Acute Kidney Damage
4. High-dose Vorinostat effective at treating relapsed lymphomas
5. Controlling spine metastases with tumor separation surgery and high-dose stereotactic radiosurgery
6. 4 lessons for effective, efficient research in health care settings
7. Depressed men with prostate cancer are diagnosed later stage, get less effective therapies
8. Non-diet approach to weight management more effective in worksite wellness programs
9. R.I. lead law effective, often ignored
10. Drug shows promise for effectively treating metabolic syndrome
11. Biomarker predicts effectiveness of brain cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Cranbury, NJ (PRWEB) December 19, 2014 ... of Inside Patient Care: Pharmacy & Clinics™, an ... entire healthcare team treating and caring for patients ... As primary care expands to provide optimal access ... Clinics™ offers a forum for the team treating ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 ... the diagnostic, personalized medicine, healthcare information technology, and ... the position of Chief Operating Officer. The announcement ... Partners, marked by a strengthened presence in Boston ... , "Leslie lives and breathes the client experience," ...
(Date:12/19/2014)... in good shape seems to reduce your risk of high ... more than 57,000 Americans, including more than 35,000 with high ... Those in the poorest shape had a more than ... start of the study, compared to a 50 percent chance ... more than 8,000 people diagnosed with high blood pressure during ...
(Date:12/19/2014)... 18, 2014 (HealthDay News) -- Traveling through the same ... virus to three others within a four-hour time span, ... new report shows. "The exposures in this report ... than an international terminal, highlighting the fact that measles ... Vega, an infectious disease specialist at the U.S. Centers ...
(Date:12/17/2014)... 17, 2014 Unidesk Corporation today ... (ACOM), which welcomed its inaugural class in August ... to seamlessly support bring your own device (BYOD) ... – experience. The solution, comprised of Citrix ... Dell server and storage infrastructure and ...
Breaking Medicine News(10 mins):Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:Being Fit Keeps Blood Pressure in Check 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 2Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 3
... , WASHINGTON , Feb. 14 Following is the ... http://www.newscom.com/cgi-bin/prnh/20090226/CENSUSLOGO ) , SUNDAY, FEBRUARY 14 : ... for the 14th day of Black History Month.  Dr. Daniel Hale ... end of the 19th century.  He founded Provident Hospital, the nation,s first ...
... , AUSTIN, Texas , Feb. 13 ... are sources of satisfaction for many gardeners. For allergy sufferers, though, ... , Pollen from trees, shrub and grasses can cause an onslaught ... cases, an asthma attack. , But sensitive people can take a ...
... improve on your personal best , SATURDAY, Feb. 13 (HealthDay News) ... you can learn from them if you want to improve your ... us to push the boundaries of human potential. As I tell ... mimic the strategies of those at the top," Chris Sebelski, an ...
... , ... largest provider of Microsoft certifications in North America, is proud to announce that CED Solutions ... for the first 500 applicants starting today. Students will also obtain a licensed copy ... ...
... ... the President,s proposed budget. , ... (PRWEB) February 13, 2010 -- President Obama presented America and Congress with his new budget ... presented throughout its 192 pages. Mountainside Addiction Treatment Center has scrubbed through the budget ...
... , , WASHINGTON , Feb. 12 ... pleased to announce that its contract with the U.S. Department of ... 30, 2010 . , "Since HITSP,s formation in 2005, the Panel ... electronic health records," said Fran Schrotter , HITSP project director ...
Cached Medicine News:Health News:U.S. Census Bureau Black History Month Feature for Feb. 14 2Health News:Avoid Allergens to Reap the Rewards of Gardening 2Health News:Avoid Allergens to Reap the Rewards of Gardening 3Health News:Train Like an Olympian: Here's How 2Health News:CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals 2Health News:New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget 2Health News:New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget 3Health News:HITSP Contract With U.S. HHS Extended Through April 2010 2Health News:HITSP Contract With U.S. HHS Extended Through April 2010 3
(Date:12/19/2014)... Mass. , Dec. 18, 2014  Decision Resources ... the United States will increase to ... will be primarily driven by expansion in the large ... energy devices will be increasingly adopted due to the ... Other key findings from Decision Resources Group,s ...
(Date:12/19/2014)... -- Baptist Health Lexington is the first facility in ... Fibrillation with Electrophysiology Services (EPS) Accreditation status from the Society ... the most common cardiac arrhythmia and has become recognized as ... stroke and possible death. More than 5 million patients in ... and the numbers are rapidly increasing as the population ages. ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
Breaking Medicine Technology:U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
... SARcode Corporation presented data today for their lead investigational ... trial, subjects receiving SAR 1118 demonstrated a reduction in ... as compared to placebo. These data were part of ... Vision and Ophthalmology (ARVO) Annual Meeting held in Fort ...
... 3, 2011 At the Board of Directors meeting held ... per share. The dividend is payable on June 15, 2011 ... About Sigma-Aldrich: Sigma-Aldrich is a leading ... to Improve the Quality of Life. Its chemical and biochemical ...
Cached Medicine Technology:SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 2SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 3
... Used for percutaneous placement of ... renal pelvis for nephrostomy drainage ... Supplied sterile in peel-open packages. ... Periodic evaluation is advised; catheter ...
... FAM-labeled probe and an Alexa 532-labeled probe that ... of the 5' UTR. This ASR requires an ... Texas Red reporter dyes like the Cepheid SmartCycler ... is comprised of a series of easy-to-use primer ...
... The HSV Non-Typing ASR contains primers and a ... 92 bp region of the HSV Type 1 ... an instrument that can detect a FAM reporter ... Cepheid Analyte Specific Reagent* (ASR) program is comprised ...
... CytoFuge 2 is the perfect solution for ... controls and new snap-seal Filter Concentrators make ... processed quickly, silently and conveniently on any ... are consistent: easy to scan monolayer cell ...
Medicine Products: