Navigation Links
High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer
Date:12/13/2007

herapy.

In the analysis, it was important to focus on the role of dose intensity, says Berry.

"In terms of just how high of a dose the chemotherapy was, some trials used very high doses, while others used more moderated doses, but still high enough to require stem cell support."

Regarding dose intensity, if a study had a big difference in dose intensity between the high and standard dose that was allowed to play a greater role in the investigators' conclusions. If a study had a smaller higher dose or if the standard dose was quite high, then it would not count as much in terms of the comparison between the high- and the standard-dose groups, explains Berry.

"Still, even adjusting for trial and dose differences, we were not able to tease out more than a marginal benefit for greater dose intensity."

The catch, Dr. Berry says, is that the chemotherapies under study are known to be effective. Therefore there has to be some sort of dose effect.

"What we are learning is that the doses used in standard chemotherapy regimens for advanced breast cancer have reached a plateau and that increasing beyond that dose is not delivering a greater benefit," says Berry. "It is likely that there are patients who respond to a specific chemotherapy type. Once you give enough of that chemotherapy to benefit those patients, there's no advantage from additional treatment. You are aiding those that were destined to benefit with moderate doses. The remainder of the patients have tumors that are not sensitive to the chemotherapy being considered and would not benefit no matter how much you give them."


'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Chemotherapy may be culprit for fatigue in breast cancer survivors
2. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
3. To evade chemotherapy, some cancer cells mimic stem cells
4. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
5. PET scans can accurately detect a breast tumors response to chemotherapy
6. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
7. New Software Program Helps Breast Cancer Survivors and Patients Fight Chemofog
8. Medicare modernization act did not change chemotherapy as feared
9. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
10. Cancer conflict with chemotherapy treatment
11. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Health Organization recommends that youth participate in a minimum ... (MVPA) each day. Studies have shown that youth ... Therefore, it stands to reason that increasing outdoor time ... new study scheduled for publication in The Journal ... after school was positively associated with MVPA. , Drs. ...
(Date:7/9/2014)... CHICAGO After Susan Wakulich was told she had an ... lay ahead of her. , "I was devastated," said Wakulich, ... suburbs. "I knew this was a serious diagnosis. Then I ... trial that involved a less invasive procedure. It was something ... is participating in a multi-center U.S. clinical trial to evaluate ...
(Date:7/9/2014)... findings from Fox Chase Cancer Center paint a relatively ... of breast cancers that have spread to the chest ... that grow into the skin, regardless of size and ... as stage III and called "locally advanced" tumors, ... cancer, often with poor survival. Locally advanced breast cancers ...
(Date:7/9/2014)... release is available in French . ... in 14 year old teens, including brain structure and function, ... accuracy who will go on to develop binge drinking within ... conscientiousness, and other variables such as life events and a ... binge drinking. Whether or not the child had had ...
(Date:7/9/2014)... have a reputation for being highly toxic, but when used ... being found to offer potential health benefits in a range ... A new compound (AP39), designed and made at the University ... targeting delivery of very small amounts of the substance to ... in Exeter have already found that the compound protects mitochondria ...
Breaking Medicine News(10 mins):Health News:Go play outside! Outdoor time promotes physical activity in youth 2Health News:New type of stent could help some brain aneurysm patients 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:What drives a child to abuse alcohol? 2Health News:Rotten egg gas holds key to healthcare therapies 2
... When patients choose to leave the hospital before the ... of inadequately treated medical conditions and the need for ... issue of Mayo Clinic Proceedings . Additionally, the ... predictors and potential interventions to help manage and improve ...
... in the international journal Chest , by Neil ... disease (COPD) who breathed a mix of 60% helium ... to exercise longer and harder than those who breathed ... significant because research has shown that patients who perform ...
... 2009Chemicals present in cranberriesand not the acidity of cranberry ... the cells that line the urinary tract, as documented ... Food , a peer-reviewed journal published by Mary Ann ... free online at www.liebertpub.com/jmf , Urinary tract ...
... Provide Information on Medicare Advantage Special Needs Plans, ... March 9 A series of free seminars ... illness maintain a healthy lifestyle and learn about ... unique needs will be offered during March at ...
... continued growthATLANTA, March 9 Reveille Software(TM) ... grown to 275 customers and expanded its ... itself for continued market growth in helping ... performance management.Reveille,s solution, Reveille Experience and Performance ...
... study show continued, significant relief of depressive symptoms, ... hospitalization and death among ESRD patientsLAWRENCE, Mass., March ... NXTM ), a leading manufacturer of innovative dialysis ... its ongoing FREEDOM study, which show that the ...
Cached Medicine News:Health News:Patients being discharged against medical advice 2Health News:Helium helps lung patients breathe easier 2Health News:New research reveals how cranberry products prevent urinary tract infections 2Health News:Seminars Offered to Missouri Seniors With Diabetes and Other Chronic Illnesses 2Health News:Reveille Software Reaches Customer Milestone and Expands Executive Team 2Health News:Reveille Software Reaches Customer Milestone and Expands Executive Team 3Health News:NxStage Reports Sustained Reduction in Clinical Depressive Symptoms for Daily Home Hemodialysis Patients After One Year 2Health News:NxStage Reports Sustained Reduction in Clinical Depressive Symptoms for Daily Home Hemodialysis Patients After One Year 3Health News:NxStage Reports Sustained Reduction in Clinical Depressive Symptoms for Daily Home Hemodialysis Patients After One Year 4
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
(Date:1/15/2014)... NEW YORK , Jan. 15, ... new market research report is available ... Global Markets and Technologies for ... on Routes of Administration ...
(Date:1/14/2014)... HAMILTON, N.J. , Jan. 14, 2014 InformEx, ... buyers and sellers of high-value chemistry, will hold the 30 ... Miami Beach Convention Center from January 21-24. ... than 3,500 attendees from top pharmaceutical, fine chemical and specialty ...
Breaking Medicine Technology:US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... BD (Becton, Dickinson and Company) (NYSE: BDX ... of its third fiscal quarter 2011 earnings conference call on ... will issue a press release detailing the quarter,s earnings earlier ... along with related slides, will be accessible through BD,s website ...
... Va., July 8, 2011 The Amerigroup Foundation recently ... the Rx Partnership to benefit the Rockbridge Area Free ... organization that works to provide uninsured Virginians with access ... broker to access and distribute free bulk prescription medications ...
Cached Medicine Technology:Amerigroup Foundation Presents Grant to Rx Partnership 2
... hand-held, point-of-care device for the qualitative detection of ... The TOX/See device can detect up to nine ... to 8 minutes and requires only a few ... packaged to maximize convenience and ease of use. ...
... The SheerVision FireFly Infinity Light ... most technologically advanced LED light ever ... ,With the FireFly Infinity you'll get ... unrestricted mobility to go whereever your ...
... SICKLEDEX detects the presence of ... requires 2ml of reconstituted solubility buffer and ... of sickle cell hemoglobin control. Each test ... with Saponin, two buffer dispensing caps and ...
... is for use as a sheath fluid ... 70ml bottle of Cytometry Concentrate dilutes to ... Compared to Cubitainers, Streck Cytometry Concentrate reduces ... money without compromising performance. Streck Cytometry Concentrate ...
Medicine Products: