Navigation Links
High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer
Date:12/13/2007

ng the treatment and that the therapy, which averages $100,000, be covered by insurance - an issue that was the subject of many lawsuits, all predicated on transplants being effective. According to Berry, approximately 20,000 women with breast cancer in the U.S. received high-dose chemotherapy.

Most randomized trials of the therapy were initiated in the 1990s and did not confirm earlier positive findings. Rather, most of these trials showed little or no benefit for women with breast cancer. The therapy's stature became even more confusing when data from a large randomized positive trial, presented on the plenary session of the 1999 American Society of Clinical Oncology, was later found to be falsified.

"It was important to do this study so it could be determined if there is any evidence of a benefit to patients, or if there is any subset of patients that benefited from the therapy," Berry says.

For their analysis, the investigators built an expansive database and looked at all 15 trials conducted in the world. More than 6,200 women were enrolled in the studies and were randomized to receive either high-dose chemotherapy (3,118 patients) or additional doses of the standard chemotherapy (3,092 patients).

The median patient follow-up was seven years and the mean age of the women enrolled in the trials was 45. Of the women, hormone receptor status was positive in 55 percent, negative in 28 percent and not available in 17 percent. The decrease in the rate of breast cancer relapse due to higher dose chemotherapy was 13 percent, which was statistically significant. However, the benefit did not translate into survival. The decrease in mortality rate was six percent.

After adjusting for age, trial, hormone status, tamoxifen use and the number of positive lymph nodes, the high-dose regimen slightly improved relapse-free survival by about eight months. However, there was no survival benefit for women who received high-dose chemot
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Chemotherapy may be culprit for fatigue in breast cancer survivors
2. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
3. To evade chemotherapy, some cancer cells mimic stem cells
4. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
5. PET scans can accurately detect a breast tumors response to chemotherapy
6. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
7. New Software Program Helps Breast Cancer Survivors and Patients Fight Chemofog
8. Medicare modernization act did not change chemotherapy as feared
9. HER-2 status predicts success of chemotherapy in breast cancer treatment, study finds
10. Cancer conflict with chemotherapy treatment
11. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... OH (PRWEB) September 22, 2014 A ... 2014, to set up the discovery phase for testosterone ... District Court, Northern District of Illinois. Wright & ... until mid October to submit initial disclosures about potential ... further instructed attorneys to continue negotiating the topics in ...
(Date:9/21/2014)... Dry Face Brushing brings benefits to facial ... Dry Brushing improves blood circulation and tone, feeding nutrients to ... toxins and debris from the skin , 3) Dry Face ... Body Brushing can and should be done daily, there are ... fragile and thinner, it needs less. Normal, dry and ...
(Date:9/21/2014)... a partial smoking ban at a homeless shelter can ... an indicator of exposure to cigarette smoke, and may ... new research. The University of Texas Health Science Center ... in the journal Addictive Behaviors . , The ... to 18 percent among adults, but among homeless adults, ...
(Date:9/21/2014)... on the physical activity benefits of active play, a ... for children, playing has no goal it is ... done alone or with friends, and it represents "an ... combat boredom, sadness, fear, or loneliness." "By focusing on ... several aspects of play that are beneficial to young ...
(Date:9/21/2014)... 2014 Burnaby Physiotherapists at Absolute PhysioCare ... in order to help them with preventative care. This ... clinic that will help clients understand their problem in ... active participation in the healing process. With higher knowledge ... be able to facilitate the therapy that is initiated ...
Breaking Medicine News(10 mins):Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 2Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 3Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 4Health News:Judge Issues CMO For Testosterone Lawsuits Alleging Heart Attacks and Strokes Caused By "Low T" Drugs Such As Androgel 5Health News:Gorgeous Skin: 3 Top Benefits of Dry Face Brushing from Sublime Beauty® 2Health News:UTHealth researchers study impact of smoking ban in homeless shelter 2Health News:Narrow focus on physical activity could be ruining kids' playtime 2Health News:Burnaby Physiotherapists Now Provide Educational Information for Preventative Care 2
... 2009 As soccer continues to grow in popularity, injuries ... Certain injuries fall into gender-based patterns and new ... causes that could help lead to better treatment, or ... Data presented at this year,s American Orthopaedic Society for ...
... MAP Pharmaceuticals, Inc. (Nasdaq: MAPP ) today announced ... license agreement with AstraZeneca related to the company,s Unit Dose ... July 8, 2009, effective immediately. All rights licensed to ... MAP Pharmaceuticals plans to suspend development of UDB, which did ...
... New Zealand, July 9 ZyGEM Corp. Ltd., a ... other life sciences applications, today announced the availability of ... GEM(R) Bacteria DNA extraction kit is capable of producing ... bacterial species, including mixed or unknown sample types. ...
... Tested on animals, liquid would be administered externally , ... developed a pain-free vaccination that might thwart ear infections ... ear infections, and surgery is often recommended for children ... microorganisms and the invasive nature of the surgical procedure ...
... July 9 Universal Health Services, Inc. (NYSE: ... to pay a cash dividend of $0.08 per share on ... 1, 2009. , , Universal Health Services, Inc. is ... subsidiaries, acute care and behavioral health hospitals, and ambulatory centers ...
... , TAMPA, Fla., July 9 With healthcare ... chairman and chief executive officer of Health Integrated, a leading ... for companies that can clearly offer solutions to drive down ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090709/FL43703LOGO ...
Cached Medicine News:Health News:Motion analysis helps soccer players get their kicks 2Health News:Motion analysis helps soccer players get their kicks 3Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 2Health News:MAP Pharmaceuticals Announces Termination of Pediatric Asthma Collaboration 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 2Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 3Health News:ZyGEM Releases Data Confirming Its prepGEM(R) Bacteria Kit Is a Simple, Universal Method for Extracting DNA from Different Bacteria Species 4Health News:Vaccine May Someday Thwart Ear Infections 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 2Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 3Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 4Health News:Health Plans Continue to Select Health Integrated to Improve Member Health, Reduce Costs 5
(Date:9/19/2014)... Sept. 19, 2014 Research and Markets ... (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast ... the purposes of this report, the human microbiome market is ... human microbiome market is expected to be valued as $294 ... CAGR of 22.3% within the forecast period of 2019-2023. The ...
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
(Date:9/19/2014)... DIEGO , Sept. 19, 2014  Lpath, ... leader in bioactive lipid-targeted therapeutics, announced today that ... 3,605,042 registered shares of common stock and 3,605,042 ... combined purchase price for one registered share of ... one unregistered share of common stock will be ...
Breaking Medicine Technology:Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
... closes various plastic primary and secondary tubes in ... heights and diameters can be sealed in one ... send-outs. The integration into other PVT Systems (e.g. ... and High Throughput Sorter RSD ProVolume ) ...
... MGB Alert Detection Reagents provide molecular ... PCR based assays. By using our MGB ... analysis, Nanogen is now able to provide ... nucleic acid sequences of specific organisms or ...
... for the detection of two genetic ... mutation on the Factor V (Leiden) ... the Prothrombin gene. Laboratories may use ... *Analyte Specific Reagents. Analytical ...
... the latest and most advanced fecal occult ... line. An immunochemical FOBT (iFOBT) with high ... proven to detect bleeding associated with more ... Because of its superior specificity for lower ...
Medicine Products: