Navigation Links
High-dose Vorinostat effective at treating relapsed lymphomas
Date:2/4/2013

ective yet against lymphomas, patients who relapse after receiving them are less likely to achieve long-term, disease-free survival when current second-line or "salvage" therapies are applied. This is because the cancers develop resistance to the drugs or the tumor's biology changes in some way to reduce their effectiveness.

Lymphoma refers to a group of cancers that strike the lymphatic system, which is a key part of the immune system. Lymphomas are broadly classified as either Hodgkin or non-Hodgkin. Some lymphomas are highly curable; others require complex treatment.

Preclinical studies at Fred Hutch and other research centers have found Vorinostat to be effective when used along with the standard chemotherapy combo, which is known by the acronym (R)ICE for rituximab, ifosphamide, carboplatin and etoposide. Vorinostat works by blocking signals to tumor-suppressor genes, which allows those genes to induce tumor cell death.

Vorinostat is approved by the Food and Drug Administration to treat cutaneous T-cell lymphoma. The standard dose is 400 milligrams per day. It is manufactured by Merck & Co.

The phase 1 trial involved 27 patients at about a dozen sites that are members of the Puget Sound Oncology Consortium. Because the drugs can be taken orally, the patients could self-treat at home. A novel two-stage dose escalation schedule developed at Fred Hutch was used to speed the time it took to determine the maximum effective dose of Vorinostat with the fewest side effects, which was 500 milligrams twice a day.

Some level of response was observed in 19 patients, including eight complete responses. The most common side effects were gastroenterological, which led researchers to recommend giving future patients preventive medicines while taking Vorinostat.

Because many of the patients were destined for an autologous hematopoietic stem cell transplant as the next treatment step, researchers also evaluated the ability to mobilize and collect the pat
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Controlling spine metastases with tumor separation surgery and high-dose stereotactic radiosurgery
2. Announcement: New Website for Effective Environmental Services Just Went Live
3. Family practice offers genetic tests to predict effective psychiatric meds, a CAMH study
4. Constipation Treatments Not Equally Effective: Review
5. Emotional stress reduces effectiveness of prostate cancer therapies in animal model
6. Candida Treatment
7. How “Yeast Infection No More” Can Help People Treat Candida Effectively - Health Reviews
8. Social Scientists call for more effective teaching in Higher Education
9. Chemo Pills Effective, But Patients May Skip Doses
10. Gastric banding an effective long-term solution to obesity
11. As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... AZ (PRWEB) December 21, 2014 Parker ... range of heating, cooling, plumbing and other similar home ... in 2014 with regard to its expert contracting services. ... industry leader that has been serving Arizona for well ... in providing the absolute best in quality customer service ...
(Date:12/21/2014)... December 21, 2014 Theme ... a new intro plugin for Final Cut Pro X ... videos, logos, and more with absolute ease.” Said Christiana ... users the tools needed to easily animate their media ... Cut Pro X users to animate pictures, videos, logos, ...
(Date:12/21/2014)... The Oncology Institute of Hope and Innovation hosted ... Whittier offices. The Hope for the Holidays Toy Drive is ... their families during the holiday season. This year, the toy ... between both offices. This event continues to be successful year ... team, store managers and assistant managers came out and not ...
(Date:12/20/2014)... BambooIndustry.com is a leading ... has announced its bamboo flooring promotion for the ... from certified suppliers, and offers the best bamboo ... the current promotion, all customers can enjoy a ... say they know BambooIndustry.com from press releases. , ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... the healthcare sector have benefited the Massage Services ... the discretionary characteristics of industry products, the anticipated 1.0% ... five-year period has provided consumers with the means to ... that have received a massage in a given year ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 3Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... ... to announce the launch of his brand-new website. Published in April 2010, the web ... assortment of fitness programs, nutritional supplements, vitamins and more. Visit the website’s new blog ... ...
... ... or anywhere in India, whether for your large business or your small ... both affordable and the latest version. Now you don,t have to run around ... - and help them choose the right options for their requirement - so ...
... Dr. McCracken’s new ... and cosmetic surgery for the eyes, eyelids, tear ducts, eyebrows and face. , ... Lafayette, CO (PRWEB) May 28, 2010 -- ... he is opening a second office in Lafayette, CO. Located at 1120 W. South ...
... education spurred many docs to prescribe recommended treatments, study ... taking part in a face-to-face program designed to review ... the way they prescribed medicine for patients with high ... that important clinical trial findings are reflected in the ...
... IL. (May 28, 2010)More than half a million women in ... half of those surgeries include removal of the ovaries. Researchers ... reduction in the risk of developing breast cancer, but it ... in these women differ from breast cancers in the general ...
... ... to Company’s Suite of Business Services , ... Dallas, TX (PRWEB) May 28, 2010 -- Dental Wealth Partners, ... Choate Financial Services, a Dallas-based financial services consulting company. “Dental Practices need an ...
Cached Medicine News:Health News:DRW Weight Loss Debuts Website to Promote Healthy Living and Nutritional Aids 2Health News:Best Deals in Software/Hardware in India @ Chabria Infotech - Kolkata 2Health News:Best Deals in Software/Hardware in India @ Chabria Infotech - Kolkata 3Health News:Best Deals in Software/Hardware in India @ Chabria Infotech - Kolkata 4Health News:McCracken Eye and Face Institute Opens New Office in Lafayette, CO 2Health News:McCracken Eye and Face Institute Opens New Office in Lafayette, CO 3Health News:Putting New Medical Guidelines Into Practice Often Difficult 2Health News:Researchers report no difference in breast cancer characteristics after oophorectomy 2Health News:Dental Wealth Partners Acquires Choate Financial Services 2
(Date:12/19/2014)... LONDON , December 19, 2014 ... authentication services in the World announced the appointment of ... Anthony R. Vonsée, as Chief Channels and Partner Officer. ... Datanomic since 2004 through to its acquisition by Oracle ... Development Director at Geneva and ...
(Date:12/19/2014)... -- You,re visiting the dentist for what you think ... she says you need a root canal. Though it,s ... several questions and feel apprehensive about your upcoming procedure. ... to worry about. The Pennsylvania Dental Association (PDA) wants ... the public may have surrounding this common procedure that ...
(Date:12/19/2014)... , Dec. 19, 2014 Breckenridge Pharmaceutical, ... multi-product agreement with MSN Laboratories Pvt. Ltd. ( ... expect to commercialize several new ANDAs.  Under the terms ... the products exclusively to Breckenridge for the U.S. market, ... its label.  Breckenridge and MSN have agreed to develop ...
Breaking Medicine Technology:Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4Root Canals Have Become More Routine 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2
... 2 Cornerstone Therapeutics Inc. (Nasdaq: ... specialty pharmaceutical company focused on acquiring, developing and commercializing ... today announced that the Company has entered into a ... Inc, also known as The Cough Company ("The Cough ...
... ,  Aug. 2 K-V Pharmaceutical Company (NYSE: ... New York Stock Exchange ("NYSE") on July 27, 2010 ...  The NYSE informed the Company that its Class A Common ... closing price of a NYSE security of not less than ...
Cached Medicine Technology:Cornerstone Therapeutics Announces Collaboration with The Cough Company 2Cornerstone Therapeutics Announces Collaboration with The Cough Company 3Cornerstone Therapeutics Announces Collaboration with The Cough Company 4K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 2K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 3K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 4K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 5K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 6K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 7K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 8K-V Pharmaceutical Company Notified by New York Stock Exchange of Non-Compliance With Continued Listing Standards 9
... to detect sequences of the following ... 2 and 3; influenza virus A ... A and B. Laboratories may ... tests., *Analyte Specific Reagents. ...
... molecular labs a more advanced alternative for ... MGB technology, combined with post-PCR dissociation melt ... provide molecular labs more powerful tools for ... or genetic mutations associated with disease, as ...
... NGEN-brand ASRs* are specifically designed for ... with two-color fluorescence detection systems. The ... the detection of mutations associated with ... as well as reagents for the ...
... offers reagents for the detection of ... the G1691A mutation on the Factor ... mutation on the Prothrombin gene. Laboratories ... homebrew tests.,, *Analyte Specific ...
Medicine Products: