Navigation Links
High-dose Vorinostat effective at treating relapsed lymphomas
Date:2/4/2013

SEATTLE Patients whose aggressive lymphomas have relapsed or failed to respond to the current front-line chemotherapy regimen now have an effective second line of attack against their disease. Reporting the results of a first-of-its-kind phase 1 clinical trial to test the effectiveness of a new class of drugs to augment standard chemotherapy, a team led by Fred Hutchinson Cancer Research Center scientists found that giving patients high doses of Vorinostat (suberoylanilide hydroxamic acid) in combination with another round of commonly used second-line drugs resulted in a 70 percent response rate, including several patients whose lymphoma cells disappeared entirely.

According to Ajay Gopal, M.D., associate member of the Fred Hutch Clinical Research Division and corresponding author of the paper, published online in the British Journal of Haematology, the study results open the way to potentially solve the dilemma of how to effectively treat patients when modern cancer drugs fail after the first try. And, he said, it sets the stage for using a new class of drugs called histone-deacetylase inhibitors (HDAC), of which Vorinostat is one, to sensitize tumor cells to the cancer-killing effects of chemotherapy.

Patients treated in the trial had several types of lymphoma, however the best responses were seen in those who had Hodgkin and diffuse large B-cell lymphomas, two of the most aggressive types that typically require a stem cell transplant to cure if they are not cured after the first line of treatment. Knocking back the cancer raises the likelihood for a successful transplant.

"The better the response, the better the outcome will be when patients proceed to a stem cell transplant designed to cure them of their disease," said Elizabeth Budde, M.D., Ph.D., a research associate in the Fred Hutch Clinical Research Division and first author of the study.

The researchers noted that while the current front-line chemotherapy drugs are the most eff
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Controlling spine metastases with tumor separation surgery and high-dose stereotactic radiosurgery
2. Announcement: New Website for Effective Environmental Services Just Went Live
3. Family practice offers genetic tests to predict effective psychiatric meds, a CAMH study
4. Constipation Treatments Not Equally Effective: Review
5. Emotional stress reduces effectiveness of prostate cancer therapies in animal model
6. Candida Treatment
7. How “Yeast Infection No More” Can Help People Treat Candida Effectively - Health Reviews
8. Social Scientists call for more effective teaching in Higher Education
9. Chemo Pills Effective, But Patients May Skip Doses
10. Gastric banding an effective long-term solution to obesity
11. As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... CA (PRWEB) June 02, 2015 ... has joined the firm in a newly created position ... accounts and support organizations committed to improving employee retention ... a wealth of marketing experience and most recently worked ... up that was recently taken over a global mobile ...
(Date:6/2/2015)... Camarillo, Calif. (PRWEB) June 02, 2015 ... designing and manufacturing high performance connector solutions and ... MINI-SNAP® advanced connector solutions to the US market. ... connector with Push-Pull locking capabilities. The self- securing ... range of demanding applications that require significant customization ...
(Date:6/2/2015)... Residents of Monarch Landing in Naperville ... a fitness class, do yoga, play volleyball, or participate ... for the Alzheimer’s Association’s Walk to End Alzheimer’s on ... part in a challenge to exercise for 60 days, ... company. , While the walk will raise awareness of ...
(Date:6/2/2015)... The Radiosurgery Society® (RSS), a ... RSSearch® Patient Registry evaluating the treatment patterns and ... the treatment of centrally located primary non-small cell ... The study, published in the May, 2015, issue ... patients with 114 centrally located lung tumors who ...
(Date:6/2/2015)... Colleen’s Dream Foundation , with fundraising ... the UNMC to support ovarian cancer research conducted by Cheng ... of the Colleen’s Dream Foundation Board of Directors. , Cundiff ... date for Colleen’s Dream Foundation and they couldn’t have picked ... Wang is a rising star in the ovarian cancer world,” ...
Breaking Medicine News(10 mins):Health News:Insightlink Communications Appoints New Director of Marketing and Client Engagement 2Health News:ODU Announces ODU MINI-SNAP® - Advanced Circular Connector Solution for Highly Customizable Applications 2Health News:Monarch Landing Takes 60-Day Exercise Challenge to Combat Alzheimer’s 2Health News:Monarch Landing Takes 60-Day Exercise Challenge to Combat Alzheimer’s 3Health News:New Study from RSSearch® Patient Registry Highlights Treatment Patterns and Clinical Outcomes of Stereotactic Radiosurgery for Central Lung Tumors 2Health News:New Study from RSSearch® Patient Registry Highlights Treatment Patterns and Clinical Outcomes of Stereotactic Radiosurgery for Central Lung Tumors 3Health News:Colleen’s Dream Foundation Grants $70,000 to the University of Nebraska Medical Center (UNMC) to Support Ovarian Cancer Research 2Health News:Colleen’s Dream Foundation Grants $70,000 to the University of Nebraska Medical Center (UNMC) to Support Ovarian Cancer Research 3
... the research bolsters the idea that humans suffering from ... help preserve function by adding antioxidants to their diet, ... devised a new cell-based gene therapy technique that could ... these diseases. , The work, led by Scripps ...
... Corporation (Nasdaq: MASI ), the inventor of ... today announced that its management is scheduled to present ... Stock Conference at The Ritz-Carlton, Laguna Niguel in Dana ... a.m. PT. A live audiocast of the presentation will ...
... SOBeFiT Magazine, the first South Florida,publication dedicated to providing ... sports for men and women, will host its sold-out, ... presented by The Sports,Club/LA, as part of the series ... On February 8th, 2009, hundreds of ...
... not immediately order routine scans for low-back pain unless ... in the Oregon Evidence-Based Practice Center at Oregon Health ... this week,s edition of the The Lancet . ... scans in patients with low-back pain but no indication ...
... Corporation,(Nasdaq: VOLC ), a leader in the ... treatment of coronary and peripheral artery,disease, today announced that ... and all of fiscal 2008 on Tuesday, February 17. ... a conference call to discuss its financial results,and operating ...
... of its top priorities--reforming the nation,s health care system--twelve pharmacy stakeholder ... Reform, which will be announced during a media briefing on February ... ... Washington, DC (Vocus) February 6, 2009 -- As the new administration ...
Cached Medicine News:Health News:Team led by Scripps Scientists increases understanding of two types of blindness 2Health News:Team led by Scripps Scientists increases understanding of two types of blindness 3Health News:Team led by Scripps Scientists increases understanding of two types of blindness 4Health News:Team led by Scripps Scientists increases understanding of two types of blindness 5Health News:Masimo to Present at the Roth Capital Partners 21st Annual OC Growth Stock Conference 2Health News:SOBeFiT Magazine Promotes its Launch With First Annual 5K Run+Walk & Fitness Festival in South Beach 2Health News:SOBeFiT Magazine Promotes its Launch With First Annual 5K Run+Walk & Fitness Festival in South Beach 3Health News:Routine scans for low-back pain do not improve outcomes 2Health News:Routine scans for low-back pain do not improve outcomes 3Health News:Volcano Corporation Schedules Fourth Quarter Conference Call, Webcast 2Health News:Pharmacy Stakeholder Groups Collaborate to Draft Pharmacy Principles for Health Care Reform 2Health News:Pharmacy Stakeholder Groups Collaborate to Draft Pharmacy Principles for Health Care Reform 3
(Date:6/2/2015)... , June 2, 2015 Today AmerisourceBergen, ... three new distribution centers in Olive Branch, ... and Newburgh, NY . The facilities ... ability to improve product access, increase supply chain efficiency ... is part of the company,s ongoing investments, more than ...
(Date:6/2/2015)... DUBLIN , June 02, 2015 ... the addition of the "Electrophysiology Market by ... (Cryoablation, RF, Microwave), Lab Devices (Mapping, Recording, Generator, ... Global Forecasts to 2019" report to their ... is estimated to grow at a significant CAGR ...
(Date:6/2/2015)... , June 2, 2015  Australian health technology ... AUD$14.8 million to rapidly progress the company,s ... KinetiGraph™ (PKG™) mobile health technology. ... further capital in the funding round. New ... high net worth individuals and also the ...
Breaking Medicine Technology:AmerisourceBergen to Build Three New Distribution Centers 2Global Electrophysiology Market Report 2015-2019 - Product, Ablation Catheter, Lab Devices & Indication Analysis 2Global Electrophysiology Market Report 2015-2019 - Product, Ablation Catheter, Lab Devices & Indication Analysis 3Global Kinetics Corporation Closes AUD$14.8 Million Capital Raising 2Global Kinetics Corporation Closes AUD$14.8 Million Capital Raising 3
... Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) ... webcast on Friday, September 17, 2010, at 7:00 a.m. ... Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs ... on September 16, 2010, to review the lorcaserin New ...
... Switzerland, and BANGALORE, India, Sept. 13 Debiopharm ... companies with a focus on the development of ... and Aurigene Discovery Technologies Ltd. (Aurigene), a Bangalore-based ... and peptide drug discovery and development from target ...
Cached Medicine Technology:Arena Pharmaceuticals to Host Conference Call and Webcast Following Lorcaserin FDA Advisory Committee Meeting 2Arena Pharmaceuticals to Host Conference Call and Webcast Following Lorcaserin FDA Advisory Committee Meeting 3Debiopharm Group™ and Aurigene Nominate Development Candidate 2Debiopharm Group™ and Aurigene Nominate Development Candidate 3
Small golf club shape tip with sharp edge. Flat serrated handle with polished finish. Most popular size or model....
Threaded ends permit guarding the needle and gouge within the handle. Set consists of one each : E0828 A needle tip, E0828 B gauge tip and E0828 C handle. Most popular size or model....
0.5 mm replacement burr for Algerbrush rust ring remover (E0815 A). Burr can also be used with Algerbrush rust ring remover (E0815 B). Dull finish....
Short 12 mm taper with needle type tip. Stainless steel. Round smooth handle with polished finish. Overall length: 2.8 inches....
Medicine Products: