Navigation Links
High dietary fat, cholesterol linked to increased risk of breast cancer
Date:1/6/2011

(PHILADELPHIA) Elevated fat and cholesterol levels found in a typical American-style diet play an important role in the growth and spread of breast cancer, say researchers at the Kimmel Cancer Center at Jefferson.

The study, published in the January issue of The American Journal of Pathology, examines the role of fat and cholesterol in breast cancer development using a mouse model. The results show that mice fed a Western diet and predisposed to develop mammary tumors, can develop larger tumors that are faster growing and metastasize more easily, compared to animals eating a control diet.

The research team led by cancer biologist Philippe G. Frank, Ph.D., Assistant Professor in the Department of Stem Cell Biology and Regenerative Medicine at Thomas Jefferson University, was interested in learning about the link between diet and breast cancer. The incidence rate of this cancer is five times higher in Western countries than in other developed countries. Moreover, studies have shown an increase in breast cancer incidence in immigrant populations that relocate from a region with low incidence. "These facts suggest strong environmental influence on breast cancer development," says Dr. Frank.

Dietary fat and cholesterol have been shown to be important risk factors in the development and progression of a number of tumor types, but diet-based studies in humans have reached contradictory conclusions. This has led Dr. Frank to turn to animal models of human cancer to examine links between cholesterol, diet, and cancer.

The research team turned to the PyMT mouse model to determine the role of dietary fat and cholesterol in tumor development. This mouse model is believed to closely parallel the pathogenesis of human breast cancer. PyMT mice were placed on a diet that contained 21.2 percent fat and 0.2 percent cholesterol, reflective of a typical Western diet. A control group of PyMT mice was fed a normal chow that had only 4.5 per
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
2. Association of fiber and colorectal cancer risk differs depending on dietary assessment method
3. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
4. Purity 12 Science: How this Dietary Supplement, Healthy Beverage and Skin Care Company is Gaining Momentum in a Down Economy
5. Gestational Diabetes Linked to Serotonin and Dietary Protein
6. Study shows how dietary supplement may block cancer cells
7. Dietary Cocoa Flavanols Improve Vascular And Blood Pressure Measures For Coronary Artery Disease Patients
8. Concentration, timing and interactions are key when it comes to dietary compounds
9. How safe and effective are herbal dietary supplements?
10. Diabetes or not, dietary habits of Aftrican-Americans are similar
11. Study findings show value of dietary supplement SAMe in treatment of adults with major depressive disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... September 16, 2014 Today, Top 10 ... the most recommended suppliers for the webmasters for people ... save money at the same time. , As an ... ) has been offering useful products at low prices ... connected to multiple GB connections to ensure that there ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Recently, the ... compared a lot of SEO hosting suppliers and announced ... most recommended suppliers for webmasters from the USA, UK, ... products (including VPS and cloud hosting) without spending a ... easy to use shared SEO hosting plans come with ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Care ... Logistics™, a component of the Hospital Operating System™ ... match patient needs with staff capacity. For the ... understanding of actual nursing and other staff capacity. ... of patient-care needs, anticipated admissions, discharges and transfers, ...
(Date:9/16/2014)... Randy Dotinga HealthDay Reporter , ... pattern baldness may face a higher risk of developing an ... a new study suggests. But, the study authors noted ... pattern of baldness should be concerned. Their study only found ... It did not prove cause and effect. "It is ...
(Date:9/16/2014)... September 15, 2014 Combining a standard chemotherapy ... from dividing improves both the survival and response ... new study by UT Southwestern Medical Center cancer ... the chemotherapy drug cisplatin with pemetrexed - an ... showed promising results for advanced, persistent, or recurrent ...
Breaking Medicine News(10 mins):Health News:Top 10 Best SEO Hosting: These Companies Are The Best Cheap SEO Hosting Suppliers In 2014 2Health News:Great SEO Hosting Suppliers Announced By Top 10 Best SEO Hosting 2Health News:Care Logistics Launches Demand Logistics as Part of the Hospital Operating System 2Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 2Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 3Health News:Cancer-fighting cocktail demonstrates promising results as treatment for advanced cervical cancer 2
... different types of dementia, but these findings are shocking. We ... study", say researchers Elisabet Englund and Hans Brunnstrm at Lund ... from the cities of Lund and Malm. All of them ... period 1996-2006 and been diagnosed with some form of dementia. ...
... Boston and Google.org have found web-based search data to be ... of outbreaks of dengue, an emerging mosquito-borne virus found in ... capture of disease-related queries in near real time, it could ... affected by dengue respond more quickly to nascent epidemics. ...
... new test that identifies the specific type of tumour they ... at the University of Edinburgh hope this improved diagnosis will ... the most effective drugs. The Edinburgh team worked with ... each of which had a different genetic signature. ...
... Private health clinics across Canada providing weight-loss surgeries are ... and at the expense of quality patient care, according to ... Chaim Bell. "The private clinics in Canada offer ... banding the upper stomach to restrict food intake to patients ...
... Randy Dotinga HealthDay Reporter , MONDAY, May 30 ... are marketed heavily toward children and teens, a leading association ... kids. Young children and teens should avoid energy drinks ... issued Monday, and routine consumption of sports drinks should be ...
... Ill. Functional magnetic resonance imaging (fMRI) may provide ... researchers at Columbia University in New York City, who ... children. Results of their study appear online and in ... is a spectrum disorder characterized by repetitive behaviors and ...
Cached Medicine News:Health News:Difficulties in diagnosing dementia type 2Health News:Searching the web for dengue 2Health News:Targeted testing offers treatment hope for ovarian cancer patients 2Health News:Private weight-loss surgery clinics shedding quality patient care 2Health News:Pediatricians Group Raps Energy and Sports Drinks for Kids 2Health News:Pediatricians Group Raps Energy and Sports Drinks for Kids 3Health News:New research may lead to improved diagnosis of autism 2
(Date:9/16/2014)... WASHINGTON , Sept. 16, 2014 The ... (NYSE: LLY ) today released results from ... that sheds light on the lupus journey and the ... also for lupus caregivers. The UNVEIL study, which involved ... the devastating impact lupus has on all aspects of ...
(Date:9/16/2014)... DIEGO , Sept. 16, 2014 Imprimis ... pharmaceutical company dedicated to delivering high quality and novel ... announced that Chief Executive Officer Mark Baum ... Annual Craig-Hallum Alpha Select Conference in New York City.  ... its Go Dropless™ campaign in ophthalmology. The presentation ...
(Date:9/16/2014)... NEW YORK , Sept. 16, 2014  Relmada ... therapies for the treatment of chronic pain, announced today ... Sloan Kettering Cancer Center (MSKCC) in a series of ... ER, a new tamper-resistant, extended release form of levorphanol. ... investigator for these studies. Dr. Pasternak ...
Breaking Medicine Technology:"UNVEIL" Survey Reveals a Life Interrupted by Lupus 2"UNVEIL" Survey Reveals a Life Interrupted by Lupus 3"UNVEIL" Survey Reveals a Life Interrupted by Lupus 4"UNVEIL" Survey Reveals a Life Interrupted by Lupus 5Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 2Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 3Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 4Relmada Therapeutics Enters Into Agreement with Memorial Sloan Kettering to Better Clarify Unique Mechanism of Action for LevoCap ER 2Relmada Therapeutics Enters Into Agreement with Memorial Sloan Kettering to Better Clarify Unique Mechanism of Action for LevoCap ER 3
... LEIDEN, The Netherlands, July 6 Three ... Therapeutics and InteRNA,Technologies - have joined public-private partnership TI ... on cancer and,inflammatory diseases, have a total budget of ... The new consortium, formed by Syncom, Synvolux Therapeutics, and,University ...
... , NEW YORK, June 30 Betsy McCaughey of the Committee ... hospital infection rates made available by the NYS Department of Health ... have the lowest infection rates - and steer clear of those ... , Betsy McCaughey, a Ph.D., founded RID in 2004 with a ...
Cached Medicine Technology:New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects 2
Our most popular saline breast implant style for over 20 years. A full, rounded look that adds greater dimension to the breast....
This Implant enhances and restores the nasal contour, The large selection of sizes with a variety of flares and lengths allows for more individualized results...
Inquire...
... at the point of care: , Only 120 ... only 70 L of whole blood (all parameters except ... of sensor cassette , safePICO mixer ensures thorough and ... in 7 seconds) * Not ...
Medicine Products: