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High-Risk Women May Often Avoid Using Tamoxifen
Date:12/4/2009

Armed with knowledge of risks, many hesitate to take breast cancer drug, study finds

FRIDAY, Dec. 4 (HealthDay News) -- Worries about side effects are a major reason why only 6 percent of American women at high risk for breast cancer are willing to take the drug tamoxifen to prevent the disease, a new study finds.

In an effort to inform women about the risks and benefits of tamoxifen, researchers at the University of Michigan Comprehensive Cancer Center created a decision aid, which was tailored to the health history of each of the 632 women in the study.

"That means, when women read this decision aid, they learned about how the drug was likely to affect them given their age, race, breast cancer history and medical history," study author Angela Fagerlin, an associate professor of internal medicine at the University of Michigan Medical School and a research investigator at the VA Ann Arbor Healthcare System, said in a university news release.

The researchers found that the decision aid helped inform the women about the risks and benefits of tamoxifen, with 63 percent correctly answering at least five of the six questions about the drug and 41 percent getting all six questions right.

However, although the women apparently achieved a high level of understanding about the risks and benefits of tamoxifen therapy, only 29 percent said they were likely to look for more information about the drug, 29 percent said they'd talk to their doctor about it and only 6 percent said they were likely to take tamoxifen. When questioned about the drug again three months later, fewer than 1 percent of the women had started taking the drug and fewer than 6 percent had sought more information or talked to their doctor about tamoxifen.

Eighty percent of the women in the study said they were worried about the drug's side effects, which can include hot flashes, sexual problems and, in rare cases, blood clots, cataracts o
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