Navigation Links
High Doses of Statins Tied to Less Arterial Plaque in Study
Date:11/15/2011

TUESDAY, Nov. 15 (HealthDay News) -- High doses of the cholesterol-lowering statins Crestor and Lipitor reduced the amount of plaque in coronary arteries and reversed the progression of coronary artery disease, new research shows.

The study included 1,385 patients who took either 40 milligrams (mg) of Crestor (rosuvastatin) or 80 mg of Lipitor (atorvastatin) daily and were followed for two years.

The major finding was that the amount of coronary artery plaque fell 0.99 percent with Lipitor and 1.22 percent with Crestor. The difference between the two drugs is not statistically significant, the researchers noted.

"Regression of plaque has been the holy grail of heart disease treatment, and in this trial more than two-thirds of the patients had regression," lead researcher Dr. Stephen J. Nicholls, cardiovascular director of the Cleveland Clinic Coordinating Center for Clinical Research in Ohio, said in an American Heart Association news release.

"It's a very positive outcome for patients and shows the benefits of high doses of statins," Nicholls added.

The findings were to be presented Tuesday at the American Heart Association annual meeting in Orlando, Fla., and are published in the New England Journal of Medicine. The study was funded by AstraZeneca, which markets Crestor.

Among the other study findings:

  • Crestor reduced total plaque in 71.3 percent of patients and Lipitor reduced total plaque in 64.7 percent of patients.
  • Average levels of "bad" low-density lipoprotein (LDL) cholesterol were 62.6 mg/dL in patients taking Crestor and 70 mg/dL in patients taking Lipitor.
  • Average levels of "good" high-density lipoprotein (HDL) cholesterol were 50.4 mg/dL in patients taking Crestor and 48.6 mg/dL in patients taking Lipitor.

"The differences between the two drugs were modest and the difference in HDL levels was less than we were anticipating based on previous studies," Nicholls said in the news release.

The patients in this study had undergone coronary angiography, usually because they'd experienced chest pain and had abnormal results on a stress test.

In previous studies of patients who had similar characteristics and took lower doses of statins, 15 percent to 20 percent suffered a heart attack or stroke or required angioplasty to open a clogged artery over two years of follow-up. The rate of such events among patients in this new study was less than half of that.

"Doctors have been reluctant to use high doses of statins, but in this study the drugs were safe, well-tolerated and had a profound impact on lipid levels, the amount of plaque in vessel walls and the number of cardiovascular events," Nicholls said.

More information

The American Academy of Family Physicians has more about coronary artery disease.

-- Robert Preidt

SOURCE: American Heart Association, news release, Nov. 15, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
2. Children with food allergies should carry 2 doses of emergency medicine
3. Botox reduces wrinkles even in less frequent doses
4. High doses of antioxidant supplements induce stem cell genetic abnormalities
5. Organic Clothing – Is Your Clothing Delivering Death in Small Doses?
6. Cumulative Radiation Doses Seen in Cardiac Imaging
7. High doses of ursodeoxycholic acid ineffective for NASH patients
8. Higher Statin Doses Linked to Fewer Heart Attacks, Stroke
9. Yale researchers find double doses of chicken pox vaccine most effective
10. Study confirms 2 vaccine doses protect children from chickenpox
11. Preparing Small Doses of Medication From Syringes Called Risky
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High Doses of Statins Tied to Less Arterial Plaque in Study
(Date:12/9/2016)... ... 2016 , ... The Pennsylvania Athletic Trainers’ Society (PATS) aired ... of 2016. The program was made possible by a Pennsylvania Department of Health ... and Human Services Administration. The broadcast, Use Your Head: Properly Managing Sport ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... pleased to announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for ... JMIR Medical Informatics . , Results of the comparative usability study demonstrate ...
(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman , ... Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont ... and attorneys from the firm’s global Life Sciences & Medical Technology Group have been ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... has been recognized for adherence to the highest standards of trauma, maternity, ... organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among the ...
(Date:12/8/2016)... San Francisco, California (PRWEB) , ... December 08, 2016 , ... ... health coaches, has raised an $18M Series B led by Canvas Ventures . ... use the capital to scale its mobile platform to serve more consumers who are ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Pa. , Dec. 9, 2016 Department ... announced temporary regulations for medical marijuana dispensaries under Act ... Pennsylvania Bulletin , and are now available online ... is needed in the plan for operation; process for ... dispensary; as well as where the dispensary facilities can ...
(Date:12/8/2016)... Calif. , Dec. 8, 2016 IRIDEX Corporation ... to offer newly issued shares of common stock, $0.01 par ... to an underwritten public offering.  The final terms of the ... time of pricing, and there can be no assurance as ... IRIDEX expects to use the net proceeds it will ...
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
Breaking Medicine Technology: