Navigation Links
High-Dose Statins May Increase Diabetes Risk
Date:6/21/2011

By Amanda Gardner
HealthDay Reporter

TUESDAY, June 21 (HealthDay News) -- High doses of the widely popular cholesterol-lowering drugs known as statins may have a downside.

A new meta-analysis finds that intensive doses of statins, such as Lipitor and Zocor, upped the risk of being diagnosed with type 2 diabetes compared with moderate doses of the drugs.

But the review still revealed a lower incidence of heart attacks, stroke and death, meaning the balance remains tipped in favor of taking statins to protect your heart.

"The benefit with respect to heart protection still favors high-dose statins because those taking high doses of statins often have heart disease so are at very high risk of further events," said Dr. Kausik K. Ray, senior author of a paper published in the June 22/29 issue of the Journal of the American Medical Association.

"Patients should get annual checks of blood sugars and, if elevated, be treated appropriately," added Ray, a professor of cardiovascular disease prevention at St. George's University of London. "Of the agents tested, the net benefit was better with high-dose atorvastatin [Lipitor] as compared with high-dose simvastatin [Zocor]."

Statins have been very successful in lowering cholesterol levels and are used in people with and without diabetes, which is a major risk factor for cardiovascular disease.

According to Ray, only about 20 percent of patients taking statins are on high doses. About 80 percent take low to moderate doses.

Ray, along with colleagues from the University of Glasgow, pooled data from five randomized studies comparing intensive statin treatment with more moderate doses.

Essentially, all of the studies involved Lipitor and Zocor, either comparing them against each other, or comparing different doses of the same medication.

All together, they involved almost 33,000 participants and an average follow-up of almost five years.

People taking high doses (80 milligrams) of one of these drugs had a 12 percent higher risk for new-onset diabetes but a 16 percent reduced risk of cardiovascular events, compared with moderate doses.

That translates to one new case of diabetes for every 500 patients treated for one year with a high-dose statin compared with one fewer patient having a stroke or heart attack for every 155 patients treated for one year.

But the study had a number of limitations, other experts stated.

For one thing, it was a meta-analysis which, says Dr. Jacob Warman, chief of endocrinology at the Brooklyn Hospital Center in New York City, "doesn't prove anything." These types of analyses tend to be more "hypothesis-generating." (When researchers conduct a meta-analysis, they synthesize previous studies to look for patterns that would not show up in an individual study).

"It's suggestive but I don't know that it's conclusive," added Dr. Steven D. Wittlin, clinical director of the diabetes service at the University of Rochester Medical Center in Rochester, N.Y.

While there was a benefit seen in macrovascular complications, such as heart attacks, it's unclear if the same would be true with microvascular complications or those that involve small blood vessels and contribute to conditions such as neuropathy, Wittlin said.

That could change the risk-benefit ratio, he noted.

Also, as the authors themselves pointed out, the biological mechanisms behind the effect are still not clearly understood.

More information

The U.S. Food and Drug Administration has more on statins.

SOURCES: Jacob Warman, M.D., chief of endocrinology, Brooklyn Hospital Center, New York City; Steven D. Wittlin, M.D., clinical director, endocrine-metabolism division, and director, Diabetes Service, University of Rochester Medical Center, Rochester, N.Y.; Kausik K. Ray, M.D., professor of cardiovascular disease prevention, St. George's University of London; June 22/29, 2011, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. High-Dose Vitamin B Risky for Diabetics With Kidney Disease
2. New model may simplify high-dose radiosurgery planning
3. Jefferson doctors strengthen case for high-dose radiotherapy technique after radical prostatectomy
4. Statins May Benefit Prostate Cancer Patients
5. Alternative to Statins Shows Promise
6. Statins may slow progression of multiple sclerosis, new study finds
7. Statins May Slow Progression of Multiple Sclerosis, New Study Finds
8. Do Statins Lower Male Sex Drive?
9. Statins Wont Lower Colon Cancer Risk
10. Statins decrease risk of clot-related diseases
11. Some statins have unintended effects and warrant closer monitoring, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
High-Dose Statins May Increase Diabetes Risk
(Date:5/24/2016)... , ... May 24, 2016 , ... Regenerative Medicine is ... in adult stem cell therapy technology, protocols and patient results as have been achieved ... to become a more accessible standard of care for patients worldwide. , As the ...
(Date:5/24/2016)... Linda, CA (PRWEB) , ... May 24, 2016 , ... ... will house the new adult hospital and expanded Children’s Hospital. Over 3,000 people looked ... 22. , Check out the event photo slidehsow. , During the program, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Boyd Industries, a leading ... Unit® (CDU), a groundbreaking new product for pediatric dentistry , at AAPD 2016, ... San Antonio, TX May 26-29. The Concealed Delivery Unit keeps dental hand pieces and ...
(Date:5/24/2016)... ... 2016 , ... A newly released report reveals that improving life outcomes for ... both in face-to-face interactions and online. In “Heard, Not Judged – Insights into the ... use of mobile digital devices can be an effective tool to help boys and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Growing in popularity, more ... more gluten-free products are available and easily accessible. Whether someone chooses to cut gluten ... to a certain diet, King Kullen Grocery stocks their shelves with many different gluten-free ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... 2016 Gamida Cell, a leader ... cancer and orphan genetic diseases, announced today it has ... from the Israel Innovation Authority (formerly the Office of ... and Industry. The mission of the Israel Innovation Authority ... including science and technology, while stimulating economic growth. ...
(Date:5/20/2016)... -- The Biotech arena remains under immense ... is not far from recovering. There are great companies ... four equities: Anacor Pharmaceuticals Inc. (NASDAQ: ANAC ... Pharmaceuticals Inc. (NASDAQ: ARLZ ), and Infinity ... for your free trading alerts on these biotech stocks ...
(Date:5/19/2016)... , May 19,2016 ... at Digestive Disease Week Meeting and 91 st ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: ... endomicroscopy platform, today announced that its Cellvizio platform ... focused on gastroenterology during the month of May. ...
Breaking Medicine Technology: