Navigation Links
High Blood Pressure May Add to Alzheimer's Risk, Study Finds

By Steven Reinberg
HealthDay Reporter

MONDAY, March 18 (HealthDay News) -- High blood pressure in people with a genetic risk for Alzheimer's disease may spur development of brain plaque, a hallmark of the age-related brain disorder, a new study suggests.

The findings suggest yet another reason for keeping blood pressure, also known as hypertension, under control, the researchers said.

"Maintaining good vascular health by avoiding or controlling diseases like hypertension has important benefits beyond keeping your heart healthy. It may promote good brain health as we age," said lead researcher Karen Rodrigue, an assistant professor of behavioral and brain sciences at the University of Texas at Dallas.

This is especially so for people who are genetically at risk for Alzheimers disease, the study suggested. "Keeping good vascular health may limit or delay the brain changes associated with Alzheimer's disease and other aging-related neurological deterioration," Rodrigue said.

No cure exist for Alzheimer's, and experts anticipate that by 2050 the number of Americans with the brain disease will approach 14 million if no progress is made.

The study of nearly 120 adults found that people with this genetic risk factor for Alzheimer's disease -- called an apolipoprotein E 4 allele -- plus untreated high blood pressure have more beta-amyloid plaques compared to those with just one or neither of these risk factors.

One expert said the findings have important implications.

"This is good news," said Dr. Sam Gandy, associate director of the Mount Sinai Alzheimer's Disease Research Center in New York City.

"This means that yet another simple intervention -- here, blood pressure control, but think also of physical exercise -- can have an important impact on dementia risk and rate of progression," Gandy said. "We must not overlook these simple effective interventions while developing new therapies."

For the study, which was published online March 18 in the journal JAMA Neurology, the researchers looked at 118 people with normal brain function who were between 47 and 89 years old. They divided the patients into those with high blood pressure and those without high blood pressure, and those with and without the genetic risk factor for Alzheimer's. The participants also were given brain scans to look for plaques.

The researchers found people with both high blood pressure and the genetic risk factor had significantly more brain plaque than those with only one or no risk factors.

Moreover, those with the highest blood pressure and the gene mutation tended to have the most plaque, they found. The study did not, however, prove a cause-and-effect relationship between high blood pressure, this genetic mutation and increased brain plaque.

High blood pressure is highly responsive to lifestyle changes and medical treatment, and it may provide a future target for delaying or preventing Alzheimer's disease, the researchers noted.

More information

For more information on Alzheimer's disease, visit the Alzheimer's Association.

SOURCES: Karen Rodrigue, Ph.D., assistant professor, behavioral and brain sciences, University of Texas at Dallas; Sam Gandy, M.D., associate director, Mount Sinai Alzheimer's Disease Research Center, New York City; March 18, 2013, JAMA Neurology, online

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experts Question Use of Ankle Blood Pressure to Gauge Heart Risks
2. Study Probes Use of Filter Device to Stop Deadly Blood Clots
3. Blood levels of fat cell hormone may predict severity of migraines
4. Vitamin D Supplements Tied to Lower Blood Pressure in Blacks
5. Blacks With Kidney Disease Should Watch for Blood Pressure Shifts: Study
6. Clot Buster Safe for Stroke Patients on Blood Thinners: Study
7. Cord blood effective alternative to matched donor stem cells for kids with rare disorder
8. Vitamin D may lower blood pressure in African-Americans
9. Blood Test Plus Targeted Care May Stop Heart Failure Before It Starts
10. Store donated blood for more than 3 weeks? Say NO (nitric oxide)
11. Drugs targeting blood vessels may be candidates for treating Alzheimers
Post Your Comments:
Related Image:
High Blood Pressure May Add to Alzheimer's Risk, Study Finds
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015 -- ... the company’s growing product line of food safety and seafood fraud prevention tools. ... nerka) – allow InstantLabs to offer fast, reliable species identification for the four ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... Annual 2015 Golden Bridge Business Awards under the New Products and Services category ... web based sample management software that helps labs organize data and ...
(Date:12/1/2015)... Chicago, Illinois (PRWEB) , ... December 01, 2015 ... ... measure and share medical images have been lifted as IMAGE Information Systems launches ... Radiology Society of North America Annual Meeting from November 29 to December 4, ...
(Date:12/1/2015)... ... December 01, 2015 , ... The importance of ... is the focus of numerous abstracts accepted for presentation here, at the 101st ... Nine abstracts highlight the use of Volpara Solutions’ quantitative breast imaging software tools ...
(Date:12/1/2015)... ... December 01, 2015 , ... For the millions ... why Hollister Incorporated has launched the VaPro Plus Pocket™ touch free hydrophilic intermittent ... VaPro touch free catheter portfolio,” said Michael Gresavage, Vice President North America. "We ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015  Today, AmerisourceBergen, a global ... a first-of-its-kind population health management program focused on ... to be built into existing employer benefit packages, ... for their care and explains how to avoid ... to help patients understand their treatment options and ...
(Date:12/1/2015)... 1, 2015  The migration to value-based care ... care plans that help patients stay healthy and ... be digitally enabled, incorporate care guidelines and be ... They will also allow all stakeholders to collaborate ... is optimal. That is the vision, however, research ...
(Date:12/1/2015)... WASHINGTON and TELTOW, Germany ... SensoMotoric Instruments (SMI) , a leading global manufacturer of ... RightEye LLC has included SMI remote eye trackers ... that help healthcare providers assess concussions, eye sight, and ... SMI RED -oem technology is part of SMI,s mass-market-ready ...
Breaking Medicine Technology: