Navigation Links
'Hidden' cancer cells not a factor in early-stage breast cancer survival rates
Date:7/26/2011

LOS ANGELES (EMBARGOED UNTIL 3 P.M. CT ON TUESDAY, JULY 26, 2011) A new study shows that removing lymph nodes due to the presence of occult, or microscopic, cancer cells found in the sentinel lymph node the one closest to the tumor -- has no impact on survival outcomes of women with early-stage breast cancer. The principal investigator of the study is Armando E. Giuliano, MD, of Cedars-Sinai, who already is renowned for his clinical expertise and for his seminal research on lymph node removal in women with early-stage breast cancer.

The latest study, conducted by the American College of Surgeons Oncology Group (ACOSOG) and supported by the National Cancer Institute, was published in the July 27 issue of the Journal of the American Medical Association. Giuliano is the executive vice chair of surgery for surgical oncology and holds several leadership positions at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute.

His previous findings related to sentinel lymph node biopsy and cancer diagnosis revolutionized the accepted approach to treating early-stage breast cancer. His groundbreaking research, published earlier this year in the Journal of the American Medical Association, challenged the commonly held belief that removing all lymph nodes not just the sentinel nodes closest to the tumors was key to improving survival rates.

The ACOSOG research showed the opposite: Survival outcomes were no different between women undergoing total lymph node removal and those only having the sentinel lymph node removed. This finding dramatically changed the surgical approach for these patients. Women now can be spared the pain and side effects of comprehensive lymph node removal.

In this new study, Giuliano and colleagues sought to determine whether there is an association between patient survival rates and the presence of microscopic cancer cells that have spread from an early-stage tumor to nearby lymph nodes.

Occult metastases usually cannot be seen in routine pathological or clinical examination. The tiny cells were detected with immunochemical staining of sentinel lymph nodes and bone marrow specimens from patients with early-stage breast cancer.

Some 5,210 women with breast cancer enrolled in the American College of Surgeons Oncology Group trial at 126 sites nationwide from May 1999 to May 2003. All subjects underwent breast-conserving surgery and sentinel lymph node dissection.

"This study shows that the presence of tiny sentinel lymph node metastases has no bearing on survival outcomes," said Giuliano, co-director of the Saul and Joyce Brandman Breast Center a Project of the Women's Guild.

According to Giuliano, removing lymph nodes can cause complications such as lymphedema, a chronic and often painful swelling in the arm that can be debilitating. "Treating the patient doesn't end with stopping the cancer," he says. "We want to make sure we maximize the patient's quality of life even after cancer treatment is completed."


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
2. Thyroid Disease: The Hidden Epidemic
3. MRIs May Detect Hidden Tumors in Breast Cancer Patients
4. Health Care Reform's Hidden Racket Exposed
5. Hidden Pond Productions Announces a Unique One-Stop Shop of Music/Talent Supervisions, IP Licensing and Original Custom Music
6. Brainstem, spinal cord images hidden in Michelangelos Sistine Chapel fresco
7. Global media campaign finds hidden children with rare, fatal aging disorder
8. Sickle Cell May Be Hidden Danger to Young Athletes
9. Mini-strokes leave hidden brain damage: Vancouver Coastal Health and UBC Research
10. Self-Drawings May Reveal Hidden Eating Disorders
11. Am I safe here?: How people with HIV/AIDS perceive hidden prejudices in their communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology: