Navigation Links
Herpes Suppression May Not Prevent HIV Infection
Date:6/19/2008

Study with antiviral aciclovir shows no added benefit

THURSDAY, June 19 (HealthDay News) -- The herpes drug aciclovir (Zovirax) doesn't reduce the risk of HIV-1 infection in people who have sex with men infected with genital herpes, a U.S. study finds.

Previous research has shown that herpes simplex virus type-2 (HSV-2) infection -- the most common cause of genital herpes -- increases the risk for HIV-1 infection by two- to threefold.

In this new, randomized, placebo-controlled phase III study, Dr. Connie Celum, of the University of Washington in Seattle, and colleagues examined whether aciclovir, an antiviral drug commonly used to help suppress genital herpes, would reduce the risk of HIV-1 infection.

The final analysis included almost 1,400 HIV-negative but HSV-2 positive women in Africa and more than 1,800 American and Peruvian men who have sex with men. Of those participants, almost 1,600 received 400 milligrams of aciclovir and a similar number received a placebo, for 12 to 18 months.

The incidence of HIV-1 infection was 3.9 per 100 person years in the aciclovir group and 3.3 per 100 in the placebo group -- not a significant difference, the researchers reported in the June 21 edition of The Lancet. In the aciclovir group, incidence of genital ulcers was reduced by 47 percent, and incidence of genital ulcers caused by HSV-2 was reduced by 63 percent.

"Our results show that suppressive therapy with standard doses of aciclovir is not effective in reduction of HIV-1 acquisition in HSV-2 seropositive women and MSM (men who have sex with men). Novel strategies are needed to interrupt interactions between HSV-2 and HIV-1," the researchers concluded.

Further research is needed to determine why aciclovir doesn't reduce the risk of HIV infection, they added.

These findings and others raise doubts about whether control of sexually-transmitted infections should be promoted specifically for HIV prevention in HIV-negative populations, Professor Ronald Gray and Professor Maria Weaver, of Johns Hopkins University, wrote in an accompanying editorial.

More information

The National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.



-- Robert Preidt



SOURCE: The Lancet, news release, June 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Ties Herpes Virus to Emerging Form of Diabetes
2. Study finds genetic link to human herpes susceptibility
3. Study shows suppressing herpes virus may reduce infectiousness of HIV
4. Vicriviroc Demonstrates Potent and Sustained Viral Suppression Through 48 Weeks of Therapy in Treatment-Experienced HIV-Infected Patients
5. Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels
6. Safe to Stop the Flow?: Differing Attitudes Found Between Women and Doctors Concerning Menstrual Suppression
7. Differing attitudes found between women and doctors concerning menstrual suppression
8. Pill box organizers increase HIV patients adherence and improve viral suppression
9. National Campaign to Prevent Teen and Unplanned Pregnancy Statement on Jamie Lynn Spears
10. U.S. Preventive Medicine Views Bernankes Comments as Strong Support for Prevention and Wellness Programs
11. Data Published in Plastic and Reconstructive Surgery Show Cohera Medicals Surgical Adhesive, TissuGlu(R), Prevents Seroma Formation in Animal Abdominoplasty Model
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Herpes Suppression May Not Prevent HIV Infection
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... BantamPro L top-load case packer for pouches, bags, and flow wrapped products at ... help co-packers and specialty product manufacturers step up to semi-automatic or fully-automatic case ...
(Date:2/8/2016)... IN (PRWEB) , ... February 08, 2016 , ... ... the Indianapolis, IN metro area, has selected the latest beneficiary of their ongoing ... organization dedicated to preventing bullying in area schools. Donations are now being accepted ...
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying ... , According to Perry A~, author of “Calcium Bentonite Clay” the health benefits of ... in balancing and detoxifying the body. , A former motivational speaker, Perry A~ has ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth cohort ... is time to make a change in public health,” states Carole Baggerly, Director ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Guruji Mahendra ... 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... happiness. Mahendra Trivedi is known by over 250,000 people from over 40 different ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 Amgen (NASDAQ: ... Annual Global Healthcare Conference at 9:15 a.m. ET on ... . David W. Meline , executive vice president ... conference. Live audio of the presentation can be accessed from ... Investors. A replay of the webcast will also be available ...
(Date:2/5/2016)... , Feb. 5, 2016  Syneron Medical ... aesthetic device company, announced today that William ... North America, is scheduled to participate in the ... Conference on February 11, 2016 in ... allow institutional investors to meet with the Mr. ...
(Date:2/5/2016)... CENTENNIAL, Colo. , Feb. 5, 2016  As ... about health. The multitude of recommended screenings and tests ... healthy aging a priority. However, for the majority of ... of proactive health planning. For the 37.5 million American ... time like the present to make hearing health a ...
Breaking Medicine Technology: