Navigation Links
Herpes: Scientists find cellular process that fights virus
Date:3/23/2009

This release is available in French.

Montreal, March 23, 2009 Scientists have discovered a new way for our immune system to combat the elusive virus responsible for cold sores: Type 1 herpes simplex (HSV-1). As reported in the advance online edition of Nature Immunology, a group of virus hunters from the Universit de Montral, in collaboration with American colleagues, have identified a cellular process that seeks out and fights herpes.

The five-year study, partially supported by the Canadian Institutes of Health Research, was a joint project with Washington University and Pennsylvania State University.

"Once human cells are infected with Type 1 herpes simplex, the virus comes back because it hides and blocks protection from our immune system," says Luc English, the study's lead author and a doctoral student at the Universit de Montral's Department of Pathology and Cell Biology. "For the first time, our research team has indentified a combative cellular mechanism in this game of hide-and-seek."

"We've found that the nuclear membrane of an infected cell can unmask Type 1 herpes simplex and stimulate the immune system to disintegrate the virus," says English.

The team made its discovery while conducting various tests in HSV-1 infected mice cells. They replicated environments when Type 1 herpes simplex thrives, namely periods of low-grade fever between 38.5 to 39 degrees, and found that herpes-fighting mechanisms were unleashed.

The research team now plans to study how activation of the herpes-combating cellular process could be applied to other illnesses. The outcome could hasten the development of therapies to prevent other immune-evading bacteria, parasites and viruses. "Our goal is to further study the molecules implicated in this mechanism to eventually develop therapies against diseases such as HIV or even cancer," says English.

According to Dr. Michel Desjardins, senior author and a professor in the Department of Pathology and Cell Biology at the Universit de Montral, treatment options might be imaginable in a decade.

"Now that we've identified the novel mechanism in cells that activate immune response to Type 1 herpes simplex, scientists are one step closer to creating new treatments that can activate the defence against this and other viruses," says Dr. Desjardins. "While it may not be possible to completely eradicate Type 1 herpes simplex in people who are already infected, at the very least, future therapies may be able to keep the virus in its dormant state."


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... July 27, 2017 , ... SSCI, a division ... 600 patent challenges worldwide, representing a milestone achievement. , As an ... development, SSCI scientists have served as expert and fact witnesses to assist our ...
(Date:7/27/2017)... ... July 27, 2017 , ... Healthy eating isn’t always easy. Currently, more than 80 percent ... time, many Americans overeat refined grains and sugar. This trend may help explain why the ... the U.S. are obese. , As a culture, we seem to have food on the ...
(Date:7/27/2017)... ... 27, 2017 , ... Team Novo Nordisk, the world’s first all-diabetes professional cycling ... as a stagiaire for the remainder of the 2017 season. One of our best ... the Tour of Utah. , “Every season we are excited to move an athlete ...
(Date:7/26/2017)... ... July 26, 2017 , ... An inventor from Salisbury, N.C., ... haven’t yet seen an effective and dignified way to keep leeches in place during ... CUP." , This invention provides an effective way to keep a leech in place ...
(Date:7/26/2017)... ... , ... Six greater Bay Area roller derby leagues are partnering with Brown Paper Tickets and ... series of blood drives in California, beginning July 29. Make ‘Em Bleed roller derby blood ... enough to have helped to save up to 2700 lives. , “The Make ‘Em Bleed ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... Fla. , July 17, 2017  MedX Holdings, ... branded medical testing, strengthening and rehabilitation equipment, today announced ... Machine Program. MedX is considered the gold standard for ... leader in specialized medical strengthening equipment. ... a lease with the physician or practice who prescribe ...
(Date:7/13/2017)... RK Logistics Group, Inc. was awarded ... Fremont, CA headquarters facility where it ... San Jose for hi-tech, pharmaceutical and ... , with its Fremont Innovation District, is excited to strategically ... resource to the hundreds of biotech, pharma and biomed companies ...
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
Breaking Medicine Technology: