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Herceptin Again Proves Mettle Against Breast Cancer
Date:1/28/2010

more aggressive, resulting in shorter survival times.

For this study, 235 women were randomly assigned to receive chemotherapy either with or without one year of Herceptin. In this arm of the trial, the Herceptin was given with chemotherapy (before surgery), then alone.

The second group of patients received chemotherapy before surgery, but no Herceptin.

All participants had either HER2-positive locally advanced breast cancer or inflammatory breast cancer, a rare and deadly form of the disease.

Seventy-one percent of women who received Herceptin were alive without a recurrence at the end of three years, versus 56 percent of women in the control group.

Encouragingly, there were few cardiac problems in the Herceptin group and those that did experience heart problems responded to drugs. Previous studies had shown a much higher rate of heart problems in patients receiving Herceptin.

More information

For more on breast cancer, visit the U.S. National Cancer Institute.



SOURCES: Jay Brooks, M.D., chairman, hematology/oncology, Ochsner Health System, Baton Rouge, La.; Jan. 30, 2010, The Lancet


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