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HerbalScience Research Identifies Key Bioactives in Nettle Extract That Inhibit Inflammation Associated with Seasonal Allergies
Date:8/26/2009

atented extraction technologies, which standardize the chemical profile of any selected botanical in order to deliver a compositionally and functionally consistent product, batch to batch. Separate assays were conducted to determine the extent of anti-inflammatory activities of the nettle extract in targeting key cellular-level processes that generate the symptoms of allergic rhinitis. The results showed the nettle extract has multiple anti-inflammatory activities that include:

  • H1 receptor inactivation and inhibition, which blocks histamine production and release;

  • Tryptase inhibition, which blocks mast cell degranulation and the subsequent release of cytokines and chemokines that cause allergy symptoms such as sneezing, nasal congestion, and itchy and watery eyes;

  • COX-1 and COX-2 (pro-inflammatory enzymes) inhibition, which blocks the formation of prostaglandin, known inflammatory mediators that trigger many responses associated with allergies and arthritis; and

  • Hematopoietic Prostaglandin D2 Synthase (HPGDS) inhibition, which specifically blocks Prostaglandin D2 production, a primary pro-inflammatory mediator in allergic rhinitis.

In addition to documenting the anti-inflammatory activities of the nettle extract, the study used advanced DART (Direct Analysis in Real Time) time-of-flight mass spectrometry technology to identify a number of specific bioactive compounds in the nettle extract that provided inhibition activities. The results suggest that the synergistic interactions of the many functional bioactives present address multiple steps in the pro-inflammatory cascade associated with seasonal allergies and other inflammatory disorders.

The article detailing the study appears in the July 2009 issue of Phytotherapy Research [Volume 23, Is
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SOURCE HerbalScience
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