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HerbalScience Research Demonstrates that Optimized Turmeric Extract Inhibits Amyloid-Beta Accumulation, a Hallmark of Alzheimer's Disease
Date:9/3/2009

earch, three standardized turmeric extracts were prepared that were enriched in curcuminoids and turmerones, two major classes of compounds present in turmeric. Each of the three proprietary extracts had a different chemical profile and was standardized using advanced extraction technology developed by HerbalScience to create herbal extracts that are dose-reliable and efficacious. The activities of the extracts were compared to standard curcuminoids.

Inhibition of amyloid aggregation and secretion was studied in vitro among the different extracts and standards, and it was found that one of the extracts had the greatest activity in inhibiting the aggregation and secretion of amyloid. This extract, containing the highest levels of curcuminoids among all of the extracts, demonstrated activity that was significantly greater than curcumin alone, the most active of the four curcuminoid standards. This result indicates that an enriched turmeric extract could be just as or more effective than curcumin, the most commonly studied turmeric material for Alzheimer's disease.

The HerbalScience study also used advanced DART (Direct Analysis in Real Time) Time-of-Flight mass spectrometry technology to generate detailed chemical profiles of each extract in order to determine the key bioactive compounds. Only 5% of the compounds were known chemicals, with the remaining 95% being identified for the first time. With further chemical analysis and identification of key bioactives, highly standardized extracts such as these could offer a rich new source for potential drug discovery for Alzheimer's and other therapeutic targets.

The journal article detailing the study will appear in the December 2009 issue of Current Alzheimer's Research (Vol. 6, No. 6). Authors are R. Douglas Shytle, Paula C. Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, and Paul Sanberg, with University of South Florida College of Medicine affiliat
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SOURCE HerbalScience Group
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