Navigation Links
Herb May Offer Hope for Autoimmune Diseases
Date:6/4/2009

l disease, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, eczema and psoriasis.

In the study, researchers gave halofuginone to mice with experimental autoimmune encephalitis (EAE), an artificially induced immune disease that resembles multiple sclerosis in humans.

They found that low-doses of halofuginone inhibited the development of Th17 cells in the mice but did not alter other kinds of T cells important for normal immune function.

Tests in human cells in the lab showed a similar inhibition of Th17 cell formation.

The researchers believe that halofuginone acts by activating a biochemical pathway known as the amino acid starvation response, or AAR, which typically protects cells when amino acids, the essential building blocks of proteins, are in short supply.

When excess amino acids were added to cultured T cells that were exposed to halofuginone, the AAR didn't switch on, allowing Th17 cells to develop.

Conversely, the researchers were able to inhibit Th17 differentiation by depleting amino acids and causing the AAR to kick in.

"When a cell senses amino acid deprivation, it tries to conserve amino acids by preventing specific types of responses that are energetically expensive," Sundrud said. "In inflamed tissues, a lot of cells are producing a lot of protein, so it would make sense that a cell with amino acid deprivation would want to block signals that promote inflammation."

Halofuginone is one of the 50 "fundamental herbs" of traditional Chinese medicine, according to the study. It has also been used as an anti-malarial agent. Decades ago, according to background information in the news release, the U.S. Army tried to improve upon its anti-malarial properties without success.

Halofuginone is also used to treat scleroderma, an autoimmune disease of the connective tissue. Because the compound is now in the public domain, the pharmaceutical industry has not sh
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Express Scripts Launches Senior Notes Offering to Finance Acquisition
2. Anadys Pharmaceuticals, Inc. Announces Pricing of Common Stock and Warrant Offering
3. US Oncology, Inc. Announces $465 Million Senior Secured Notes Offering
4. Medi-Share Program Announces New Healthcare Program Offerings for Christian Community
5. Ambry Genetics Announces Launch of Chromosomal Microarray to Offer Whole Genome Analysis
6. Quest Diagnostics Announces Early Tender Results of Offer to Purchase Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes
7. Photos: Philips Expands Home Healthcare Commitment With Portable Life-Support Ventilator; Offers Ease of Use, Portability and Versatility for Patient
8. Governor Rendell Proposes Offering Prescription Help to 30,000 More Older Adults as Part of Plan to Save $60 Million
9. PA Professional Fire Fighters Association is First State Association in Nation to Offer Smoking Cessation Program
10. I-SPY trial offers key insights into locally advanced breast cancer
11. CSC Offers Medicare Secondary Payer Reporting to Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Herb May Offer Hope for Autoimmune Diseases
(Date:8/1/2015)... ... , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair Care, has ... business donation to kick off the campaign for healing and Well-Being. , BeverlyD has ... complete line of raw, organic hair care products, as well as her book, Hair ...
(Date:7/31/2015)... Las Vegas, NV (PRWEB) , ... July 31, 2015 , ... Ticket Down is a ... Las Vegas at the MGM Grand Garden Arena. Fans of every genre of music ... On Friday, September 18th, the first day of the festival, the following artists will perform: ...
(Date:7/31/2015)... ... , ... Ticket Down is a reliable source for authentic tickets for the ... The festival will end on Sunday, August 2nd. , Music fans ... This unique and unbelievably popular festival attracts the best in entertainment from around ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2nd annual Ride ... in Downtown Memphis on October 3, 2015. The Ride to Fight On is a ... research between Methodist Healthcare, The West Clinic and The University of Tennessee Health Science ...
(Date:7/31/2015)... ... July 31, 2015 , ... Facebook, ... Inc. has re-branded their social media profiles to better connect with the public. ... to communicate, find information, share insights and opinions. The Rally Insurance Group, Inc.’s ...
Breaking Medicine News(10 mins):Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2
... Today, the University HealthSystem,Consortium (UHC) announced that Julie Cerese, ... Safety. Cerese returned to UHC after spending,a year ... control at Northwestern,Memorial Hospital in Chicago, Ill. Previously, ... area. , "Julie,s ...
... times as likely as all other children and almost ... uninsured, according to a report in the December issue ... the JAMA/Archives journals. , Children of farm workers face ... in the article. Most are Latino, a group that ...
... risk, data review finds , , TUESDAY, Dec. 2 (HealthDay News) ... safety of the drug Trasylol (aprotinin), used to limit bleeding ... of controversy in the United States, where it was removed ... Canadian and Australian researchers reviewed findings from 49 randomized clinical ...
... December 2, 2008 at 3 pm CST)--Radiology and ... Carolina in Charleston, S.C., today present new data ... to radiation during computed tomography for cardiovascular disease ... several times lower than previously published conclusions. ...
... 2 United American Healthcare,Corporation (Nasdaq: UAHC ... a managed care organization in Tennessee, today,announced that its ... the Company to repurchase up to $1.0 million of ... The program allows for the Company,s common shares ...
... of health professionals, community-based organizations, elected officials and other ... neighborhoods in Detroit/Wayne County to solidify participants, understanding of ... challenges play a role in determining health status. ... a three-day discussion to consider how to reduce health ...
Cached Medicine News:Health News:Julie Cerese Returns to University HealthSystem Consortium as Vice President of Quality and Patient Safety 2Health News:1/3 of farm workers' children lack health insurance 2Health News:Another Study Warns of Risk From Cardiac Surgery Drug 2Health News:Radiological Society of North America research: Cancer risk from cardiac CT overstated 2Health News:United American Healthcare Corporation Announces Stock Repurchase Program 2Health News:Think Tank Investigates the Environmental Conditions Surrounding Health Inequities 2Health News:Think Tank Investigates the Environmental Conditions Surrounding Health Inequities 3
(Date:7/30/2015)... IRVINE, Calif. , July 30, 2015 /PRNewswire/ ... Novartis /Alcon executives have recently contacted the Company ... will begin as early as Monday, August 3, ... been quoted as saying that the coming electronic ... billions of dollars over the next several years.  ...
(Date:7/30/2015)... PLAINFIELD, N.J., July 30, 2015 PTC Therapeutics, ... update and reported financial results for the second quarter ... progressing on many fronts across the organization.  We are ... Duchenne muscular dystrophy clinical trial ever conducted with topline ... Peltz, Ph.D., Chief Executive Officer, PTC Therapeutics, Inc. "Translarna ...
(Date:7/30/2015)... 30, 2015  Growth of the U.S. nonprescription market ... former prescription users to the OTC market. Due to ... robust Rx-to-OTC switch activity over the next five years ... many new brands entering the market into existing categories. ... five years (even those with low to moderate likelihood), ...
Breaking Medicine Technology:PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... Nov. 4 GSI Group Inc. (the "Company") (Nasdaq: ... today announced that it received notification from the Nasdaq Hearings ... shares from the Nasdaq Stock Market and will suspend trading ... on November 5, 2009. The Panel,s determination was made in ...
... .decimal, Inc., leading manufacturer of patient-specific medical devices, ... office in Japan will further strengthen .decimal,s commitment to ... ) , Richard Sweat, President/CEO of .decimal ... another example of our dedication to provide cancer patients ...
Cached Medicine Technology:GSI Group Inc. Announces NASDAQ Delisting and Reports Progress on Revenue Recognition Review and Preliminary Third Quarter 2009 Bookings and Cash Balance 2GSI Group Inc. Announces NASDAQ Delisting and Reports Progress on Revenue Recognition Review and Preliminary Third Quarter 2009 Bookings and Cash Balance 3GSI Group Inc. Announces NASDAQ Delisting and Reports Progress on Revenue Recognition Review and Preliminary Third Quarter 2009 Bookings and Cash Balance 4GSI Group Inc. Announces NASDAQ Delisting and Reports Progress on Revenue Recognition Review and Preliminary Third Quarter 2009 Bookings and Cash Balance 5GSI Group Inc. Announces NASDAQ Delisting and Reports Progress on Revenue Recognition Review and Preliminary Third Quarter 2009 Bookings and Cash Balance 6Japanese Cancer Patients Will Have Access to Compensator-Based IMRT with Opening of .decimal, Inc. Office in Tokyo and Hiring of Key Personnel 2
The Vision Premier software features advanced,capabilities, including automatic categorization,of beats, tachogram review and full-disclosure,viewing, providing the tools needed for even,the ...
The Deltec Cozmo® insulin pump is small, about the size of a cell phone, and only weighs 3.3 ounces (w/ battery and full cartridge). Its ergonomic design fits comfortably in the palm of your han...
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
... was designed specifically to meet the varying needs ... a simple to use, compact, dual application system ... field of light based hair removal. SpaTouch works ... safe for use on nearly all face and ...
Medicine Products: